Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 20, Problem 27P
ABO blood type is examined in a Taiwanese population, and allele frequencies are determined. In the population,
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What is the expected genotype frequency of the heterozygous genotype under the Hardy-Weinberg equation P = 0.7?
A study on blood types in a population found the following genotypic distribution among the people sampled: 1101 were MM, 1496 were MN and 503 were NN.
i) calculate the allelic genotypic frequencies.
ii) using x² test, determine whether or not this population is in Hardy-Weinberg equilibrium. Important information from the x² distribution is given in the picture attached.
Pretend that you are comparing the actual genotype distribution for a population with the distribution of genotypes predicted by the Hardy-Weinberg theorem. So you hypothesize that the population is in Hardy-Weinberg equilibrium (i.e. that actual population data fit the Hardy-Weinberg expectations). If you carry out chi-square goodness of fit test and calculate a total chi-square value of 0.03 with 1 degree of freedom (see table), what does this mean?
Chapter 20 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 20 - 20.1 Compare and contrast the terms in each of the...Ch. 20 - In a population, what is the consequence of...Ch. 20 - 20.3 Identify and describe the evolutionary forces...Ch. 20 - Describe how natural selection can produce...Ch. 20 - Thinking creatively about evolutionary mechanisms,...Ch. 20 - 20.6 Genetic drift, an evolutionary process...Ch. 20 - Over the course of many generations in a small...Ch. 20 - Catastrophic events such as loss of habitat,...Ch. 20 - 20.9 George Udny Yule was wrong in suggesting that...Ch. 20 - 20.10 The ability to taste the bitter compound...
Ch. 20 - Figure 20.6 illustrates the effect of an ethanol ...Ch. 20 - 20.12 Biologists have proposed that the use of...Ch. 20 - 20.13 Two populations of deer, one of them large...Ch. 20 - 20.14 Directional selection presents an apparent...Ch. 20 - 20.15 What is inbreeding depression? Why is...Ch. 20 - 20.16 Certain animal species, such as the...Ch. 20 - Genetic Analysis 20.1 predicts the number of...Ch. 20 - 20.18 In a population of rabbits, and . The...Ch. 20 - Sickle cell disease (SCD) is found in numerous...Ch. 20 - 20.20 Epidemiologic data on the population in the...Ch. 20 - The frequency of tasters and nontasters of PTC...Ch. 20 - Tay-Sachs disease is an autosomal recessive...Ch. 20 - 20.23 Cystic fibrosis (CF) is the most common...Ch. 20 - 20.24 In the mouse, Mus musculus, survival in...Ch. 20 - 20.25 In a population of flowers growing in a...Ch. 20 - Assume that the flower population described in the...Ch. 20 - 20.27 ABO blood type is examined in a Taiwanese...Ch. 20 - 20.28 A total ofmembers of a Central American...Ch. 20 - 20.29 A sample offield mice contains individuals...Ch. 20 - Prob. 30PCh. 20 - Albinism, an autosomal recessive trait...Ch. 20 - 20.32 The frequency of an autosomal recessive...Ch. 20 - 20.33 Evaluate the following pedigree, and answer...Ch. 20 - Evaluate the following pedigree, and answer the...Ch. 20 - The following is a partial pedigree of the British...Ch. 20 - Draw a separate hypothetical pedigree identifying...Ch. 20 - Prob. 37PCh. 20 - 20.38 Achromatopsia is a rare autosomal recessive...Ch. 20 - 20.39 New allopolyploid plant species can arise by...
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- How Can We Measure Allele Frequencies in Populations? What are four assumptions of the HardyWeinberg law?arrow_forwardPretend that you are comparing the actual genotype distribution for a population with the distribution of genotypes predicted by the Hardy-Weinberg theorem. So your hypothesis is that the population is in Hardy-Weinberg equilibrium (i.e. that actual population data fit the Hardy-Weinberg expectations). If you carry out a chisquare goodness of fit test and calculate a total chisquare value of 0.03 with 1 degree of freedom (see table), what does this mean? (select all true statements)a) The data do NOT fit the hypothesized distribution.b) The data do fit the hypothesized distribution well enough, so we accept the hypothesis at this time (i.e. we cannot reject the hypothesis). c) The probability that the data came from a population in Hardy-Weinberg equilibrium is too small, so we reject the hypothesis.d) The probability that the data came from a population in Hardy-Weinberg equilibrium is too big, so we reject the hypothesis.e) The data support Hardy-Weinberg expectations – there is no…arrow_forwardin the Hardy-Weinberg equation, what do the terms p2, q2, and 2pq represent, in terms of the genetic structure of a population?arrow_forward
- In a population of 200 people, an allele F has a frequency of 84%. What is the frequency of allele f? Using the Hardy-Weinberg equation, estimate the numbers of homozygous dominant, heterozygous, and homozygous recessive genotypes. (Remember that the formula is: p2 + 2pq + q2 = 1, where p represents the dominant allele and q represents the recessive allele.) *Be sure to account for all 200 people in the population.arrow_forwardThe following data were obtained from a Ghanaian population of 152 people. Blood Type Number of Individuals M 61 MN 64 N 27 Calculate the frequencies of the M and N alleles in this population. What are the expected numbers of individuals of each genotypic class in this population? Assume Hardy-Weinberg conditions. Use the chi-squared test to determine if these data fit the Hardy-Weinberg equilibrium model. The degrees of freedom for this test should be 1. Why is this appropriate?arrow_forwardConsider an autosomal locus with alleles A and a. If the the allele frequencies are as follows Freq(A) = 0.4, Freq(a) = 0.6. , then what is the predicted frequency of heterozygous Aa individuals, assuming the population is in Hardy-Weinberg equilibrium? Freq(Aa) = ? Enter a number between 0 and 1, inclusive, for example 0.33arrow_forward
- In a human population, the following data were obtained for numbers of people with each blood type (for 3 alleles, use 3 variables p,q, and r ; Hardy-Weinburg equation becomes (p^2 + q^2 + r^2 +2pq + 2pr + 2qr = 1):Type O – 804Type A – 997Type B – 295Type AB – 177Is this population in Hardy-Weinberg equilibrium? Explain.arrow_forwardConsider a Hardy-Weinburg Equilibrium population with an autosomal locus of 2 alleles, A1 and A2. If P(A1A2) = 8 * P(A1A1), what are the allele frequencies at the locus?arrow_forwardWhile studying the frequency of sickle-cell disease ("sickle cell anemia") in a population living in sub-Saharan Africa, you obtain the following data from a sample of n= 100 people (note that I chose a simpler system for identifying the alleles rather than using "Hb S" for sickle cell allele), which is the actual name and what you used in lab). What is the frequency of the sickle cell allele (b) in the sample below from a human population? Sample Data BB-60 individuals (No sickle cell disease) Bb-30 individuals (No sickle cell disease) bb-10 individuals (Sickle cell disease) 1. 0.25 2. 0.10 3. 0.35 4. 0.60 5. 0.20arrow_forward
- (1 point) Humans with the genotypes DD and Dd show the Rh+ blood phenotype, whereas those with the genotype dd show the Rh- blood phenotype. In a sample of 400 Basques from Spain, 230 people were Rh+ and 170 people were Rh-. Assuming that this population is in Hardy-Weinberg proportions, what is the allele frequency of the allele D? (a) (a) 0.348 (answer) (b) (b) 0.652 (c) (c) 0.425 (d) (d) 0.575 (e) (e) 0.288 2. (2 points) In the Basque population mentioned above, what proportion of the Rh+ individuals would be expected to be heterozygote? (a) (a) 0.454 (b) (b) 0.789 (answer) (c) (c) 0.516 (d) (d) 0.250 (e) (e) 0.500 How is the answer for #2, b? please explainarrow_forwardConsider a population in which the D locus has two alleles, D and d, with f(D) = 0.6 and f(d) = 0.4. What are the genotypic frequencies expected under Hardy-Weinberg equilibrium?arrow_forwardNieman-Pick Syndrome involves a defective enzyme, sphyngomylinase. It is usually fatal before the age of 3. The defective allele frequency is 0.01 in Ashkenazi populations. Let’s call the healthy allele A, and the lethal allele a. a) What is the frequency of allele A? Assuming Hardy-Weinberg equilibrium, how many people do you expect to have the three genotypes in a population of 10,000? b) AA:_______ c) Aa:________ d) aa:_________arrow_forward
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