Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 20, Problem 23P
Cystic fibrosis (CF) is the most common autosomal recessive disorder in certain Caucasian populations. In some populations, approximately
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A prospective groom, who is normal, has a sister with cystic fibrosis (CF), an autosomal recessive disease. Their parents are normal. The brother plans to marry a woman who has no history of CF in her family. What is the probability that they will produce a CF child? They are both Caucasian, and the overall frequency of CF in the Caucasian population is 1/2500—that is, 1 affected child per 2500. (Assume the population meets the Hardy–Weinberg assumptions.)
Sickle cell anemia is a genetically inherited autosomal recessive trait in which results in a condition that there are not enough healthy red blood cells to carry oxygen throughout the body due to the production of red blood cells that are sickle shaped. The frequency of the sickle cell condition is as high as 10% in Central Africa compared to 0.5% in the United States.
Calculate the frequency of the normal and carries of the sickle cell condition.
Two parents, without any family history of cystic fibrosis (CF), have a child with CF.
A. What do you predict the genotypes of the parents to be? (CF is a recessive disorder.)
B. What is the chance that the next child of these two parents will also have CF?
Chapter 20 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 20 - 20.1 Compare and contrast the terms in each of the...Ch. 20 - In a population, what is the consequence of...Ch. 20 - 20.3 Identify and describe the evolutionary forces...Ch. 20 - Describe how natural selection can produce...Ch. 20 - Thinking creatively about evolutionary mechanisms,...Ch. 20 - 20.6 Genetic drift, an evolutionary process...Ch. 20 - Over the course of many generations in a small...Ch. 20 - Catastrophic events such as loss of habitat,...Ch. 20 - 20.9 George Udny Yule was wrong in suggesting that...Ch. 20 - 20.10 The ability to taste the bitter compound...
Ch. 20 - Figure 20.6 illustrates the effect of an ethanol ...Ch. 20 - 20.12 Biologists have proposed that the use of...Ch. 20 - 20.13 Two populations of deer, one of them large...Ch. 20 - 20.14 Directional selection presents an apparent...Ch. 20 - 20.15 What is inbreeding depression? Why is...Ch. 20 - 20.16 Certain animal species, such as the...Ch. 20 - Genetic Analysis 20.1 predicts the number of...Ch. 20 - 20.18 In a population of rabbits, and . The...Ch. 20 - Sickle cell disease (SCD) is found in numerous...Ch. 20 - 20.20 Epidemiologic data on the population in the...Ch. 20 - The frequency of tasters and nontasters of PTC...Ch. 20 - Tay-Sachs disease is an autosomal recessive...Ch. 20 - 20.23 Cystic fibrosis (CF) is the most common...Ch. 20 - 20.24 In the mouse, Mus musculus, survival in...Ch. 20 - 20.25 In a population of flowers growing in a...Ch. 20 - Assume that the flower population described in the...Ch. 20 - 20.27 ABO blood type is examined in a Taiwanese...Ch. 20 - 20.28 A total ofmembers of a Central American...Ch. 20 - 20.29 A sample offield mice contains individuals...Ch. 20 - Prob. 30PCh. 20 - Albinism, an autosomal recessive trait...Ch. 20 - 20.32 The frequency of an autosomal recessive...Ch. 20 - 20.33 Evaluate the following pedigree, and answer...Ch. 20 - Evaluate the following pedigree, and answer the...Ch. 20 - The following is a partial pedigree of the British...Ch. 20 - Draw a separate hypothetical pedigree identifying...Ch. 20 - Prob. 37PCh. 20 - 20.38 Achromatopsia is a rare autosomal recessive...Ch. 20 - 20.39 New allopolyploid plant species can arise by...
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- Tony has a sister with cystic fibrosis (CF). Neither of his parents have CF, nor does Tony. Tony is expecting a child with Tina. Tina does not have CF, but otherwise her family history is unknown. A) What is the probability that Tony is heterozygous for the CF gene? B) If the frequency of heterozygotes in the general population is 1/50, what is the probability that Tony and Tina's child will have CF?arrow_forwardA prospective groom, who is unaffected, has a sisterwith cystic fibrosis (CF), an autosomal recessive disease.Their parents are unaffected. The brother plans to marrya woman who has no history of CF in her family. Whatis the probability that they will produce a CF child? Theyare both Caucasian, and the overall frequency of CF inthe Caucasian population is 1/2500—that is, 1 affectedchild per 2500. (Assume the population meets the Hardy–Weinberg assumptions.)arrow_forwardCystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF. a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF? b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected? c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?arrow_forward
- Torsion dystonia is a movement disorder that affects 1 in every 1,000 persons of Eastern European (Askenazi) Jewish descent. What is the carrier frequency for this population?arrow_forwardBACKGROUND: Sickle cell disease is caused by a change in the gene for hemoglobin, which is the oxygen-carrying protein in red blood cells. Individuals who are homozygous for the sickle cell trait often cannot endure exercise. Individuals who are heterozygous for the trait can have sickle cell attacks under extreme conditions. Normal individuals (genotype: Hbnorm Hbnorm ) have only normal hemoglobin. Homozygous sickle cell individuals (genotype: Hbsc Hbsc ) 'have only sickle cell hemoglobin. Heterozygous individuals (genotype: Hbnorm Hbsc ) have both normal and sickle cell hemoglobin. terry Smith collapsed while running a race for his track team. A doctor said he had a sickle cell attack. Genetic tests were run on several family members. The test results are shown below. An X indicates that form of hemoglobin in red blood cells. PROBLEM: How can you determine the genotypes of people in a family? Subject Normal Hemoglobin Sickle Cell Hemoglobin Jerry Jerry's brother Jerry's younger…arrow_forwardSickle cell disease (SCD) affects millions of people throughout the world; the CDC "Centers for Disease Control and Prevention" estimated that in the United States: SCD affects approximately 100,000 Americans. SCD occurs among about 1 out of every 365 Black or African-American births. SCD occurs among about 1 out of every 16,300 Hispanic-American births. About 1 in 13 Black or African-American babies is born with sickle cell trait (SCT). What do sickle cells mean? And how does this disease affect the human body? Why do Some experts state it can have some benefits?arrow_forward
- Give only typing answer with explanation and conclusion Travis and Marcy, a Caucasian couple, are pregnant with their first child. Travis has a prior child with cystic fibrosis (autosomal recessive). He has refused to pursue carrier testing but Marcy has had negative carrier testing. Note: Carrier testing can identify 90% of carriers of CF accurately and approximately 1/25 Caucasian's are carriers of CF. What is the chance they will have a child with CF? Group of answer choices 1/964 1/140 1/25 1/209arrow_forwardTravis and Marcy, a Caucasian couple, are pregnant with their first child. Travis has a prior child with cystic fibrosis (autosomal recessive). He has refused to pursue carrier testing but Marcy has had negative carrier testing. Note: Carrier testing can identify 90% of carriers of CF accurately and approximately 1/25 Caucasian's are carriers of CF. What is the chance they will have a child with CF? 1/140 1/25 1/964 Need it ASAP pleasearrow_forwardA recessive disease is represented in 8% of the US population. What is the frequency of homozygous dominant, heterozygous and homozygous recessive individuals in the US population for that disease Homozygous dominant: 0.36 Heterozygous: 2 x 0.36 x 0.64 Homozygous recessive: 0.64 Homozygous dominant: 0.362 Heterozygous: 2 x 0.36 x 0.64 Homozygous recessive: 0.642 Homozygous dominant: 0.72 Heterozygous: 2 x 0.72 x 0.28 Homozygous recessive: 0.28 Homozygous dominant: 0.722 Heterozygous: 2 x 0.72 x 0.28 Homozygous recessive: 0.282arrow_forward
- Sickle-cell disease is an autosomal recessive genetic disorder. How many mutated hemoglobin alleles do people with sickle-cell disease have?arrow_forwardCystic fibrosis is an autosomal recessive disorder that affects 1 in 3 000 newborns with Caucasian background. It causes thick mucus build up in various organs and can cause damages and problems in respiratory and digestive systems. a) What is the frequency of the cystic fibrosis allele in the Caucasian population? Show all your work and express your answer as a value between 0 and 1 rounded to two decimal places. b) What percentage of the Caucasian population would be carriers for cystic fibrosis? Show all your work and express your answer rounded to two decimal places. c)If two individuals are carriers of the cystic fibrosis allele, what is the probability that they would have a girl without cystic fibrosis? Show all your work (including the Punnett square) and express your answer as a value between 0 and 1 rounded to two decimal places.arrow_forwardCystic fibrosis is an autosomal recessive disease characterized by two copies of a mutated CFTR gene. If one in 100 (hypothetical scenario, not reality) people in the United States have cystic fibrosis, calculate the p and q frequency for the normal allele (p) and the mutated allele (q). Based on those calculations, what percentage of individuals would be expected to be homozygous dominant?arrow_forward
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY