Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 20, Problem 22P
Tay-Sachs disease is an autosomal recessive neurological disorder that is fatal in infancy. Despite its invariably lethal effect, Tay
a. What is a genetic bottleneck?
b. Explain how a genetic bottleneck and its aftermath could result in a population that carries a lethal allele in high frequency
c. In the population described, what is the frequency of the recessive allele that produces Tay
d. Assuming mating occurs at random in this population, what is the probability a couple are both carriers of Tay
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Assume that 10% of the members of a population will get a particular disease over the course of their lifetime. Genomic studies reveal that 5% of the population have sequences in their genomes such that their probability of getting the disease over the course of their lifetimes is 50%. What is the average lifetime risk of this disease for the remaining 95% of the population without these sequences?
Sickle cell anemia is a genetically inherited autosomal recessive trait in which results in a condition that there are not enough healthy red blood cells to carry oxygen throughout the body due to the production of red blood cells that are sickle shaped. The frequency of the sickle cell condition is as high as 10% in Central Africa compared to 0.5% in the United States.
Malaria is a disease caused by a parasite that infects healthy red blood cells and can lead to death. However, the parasite is not able to infect sickle cell red blood cells. Scientists claim that the higher frequency of sickle cell carriers is due to the presence of malaria. Provide reasoning to support the claim.
The prevalence (frequency) of sickle-cell disease in Canada is quite low, affecting 1/3800 individuals. However, in some African populations 1/25 individuals are affected by sickle-cell disease. The difference in frequency of this allele within the differing populations has to do with the adaptation pressures that exist in the different environments. Individuals with the heterozygous genotype have a survival advantage in environments where the disease malaria is prevalent as the presence of this mutant allele leads to resistance to malaria. Therefore, the sickle-cell disease tends to be more frequent in environments where the malaria parasite is most common.
Question:
Explain why the sickle-cell disease remains frequent in some populations while it exists in very low frequency in other populations.
Chapter 20 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 20 - 20.1 Compare and contrast the terms in each of the...Ch. 20 - In a population, what is the consequence of...Ch. 20 - 20.3 Identify and describe the evolutionary forces...Ch. 20 - Describe how natural selection can produce...Ch. 20 - Thinking creatively about evolutionary mechanisms,...Ch. 20 - 20.6 Genetic drift, an evolutionary process...Ch. 20 - Over the course of many generations in a small...Ch. 20 - Catastrophic events such as loss of habitat,...Ch. 20 - 20.9 George Udny Yule was wrong in suggesting that...Ch. 20 - 20.10 The ability to taste the bitter compound...
Ch. 20 - Figure 20.6 illustrates the effect of an ethanol ...Ch. 20 - 20.12 Biologists have proposed that the use of...Ch. 20 - 20.13 Two populations of deer, one of them large...Ch. 20 - 20.14 Directional selection presents an apparent...Ch. 20 - 20.15 What is inbreeding depression? Why is...Ch. 20 - 20.16 Certain animal species, such as the...Ch. 20 - Genetic Analysis 20.1 predicts the number of...Ch. 20 - 20.18 In a population of rabbits, and . The...Ch. 20 - Sickle cell disease (SCD) is found in numerous...Ch. 20 - 20.20 Epidemiologic data on the population in the...Ch. 20 - The frequency of tasters and nontasters of PTC...Ch. 20 - Tay-Sachs disease is an autosomal recessive...Ch. 20 - 20.23 Cystic fibrosis (CF) is the most common...Ch. 20 - 20.24 In the mouse, Mus musculus, survival in...Ch. 20 - 20.25 In a population of flowers growing in a...Ch. 20 - Assume that the flower population described in the...Ch. 20 - 20.27 ABO blood type is examined in a Taiwanese...Ch. 20 - 20.28 A total ofmembers of a Central American...Ch. 20 - 20.29 A sample offield mice contains individuals...Ch. 20 - Prob. 30PCh. 20 - Albinism, an autosomal recessive trait...Ch. 20 - 20.32 The frequency of an autosomal recessive...Ch. 20 - 20.33 Evaluate the following pedigree, and answer...Ch. 20 - Evaluate the following pedigree, and answer the...Ch. 20 - The following is a partial pedigree of the British...Ch. 20 - Draw a separate hypothetical pedigree identifying...Ch. 20 - Prob. 37PCh. 20 - 20.38 Achromatopsia is a rare autosomal recessive...Ch. 20 - 20.39 New allopolyploid plant species can arise by...
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- Tay–Sachs disease is an autosomal recessive disorder. Among Ashkenazi Jews, the frequency of Tay–Sachs disease is 1 in 3600. Assuming the Ashkenazi population is in Hardy-Weinberg equilibrium, what proportion of the population is expected to be carriers (e.g. heterozygous) for the Tay–Sachs allele?arrow_forwardThe recessive allele that causes Ellis– van Creveld syndrome when homozygous has a frequency of about 0.07 in the Amish population of Pennsylvania, although its frequency is only about 0.001 in the generalpopulation. How many persons out of one thousand in the Amish population would be expected to have the disease? How many out of one million in the general population?arrow_forwardDespite their excellent hygienic practices, the Kelatavicla lab experiences a devastating bacterial infection in their mouse population in 2012. Given the conditions in column B, predict what will happen to the frequency of the R allele over the years (increase, decrease, or remain the same) if the outbreak is not contained?arrow_forward
- Cystic fibrosis (CF) is an autosomal recessive disorderthat occurs relatively frequently among people ofEuropean descent. In an Amish community in Ohio,medical researchers reported the occurrence of cysticfibrosis (CF) as being 1/569 live births. Using theHardy–Weinberg rule, estimate the frequency of carriers of the disease allele in this Amish population.arrow_forwardTay-Sachs disease is a recessive genetic disease. Individuals with this disease rarely survive past the age of four. In the general population, approximately 1 person in 300 carries the allele for this disease. However, in some populations, including the Irish Americans, the Ashkenazi Jews, and the Cajuns from Louisiana, the proportion of Tay-Sachs carriers is much higher (1 in 27 to 1 in 50) than in other populations. Such high frequency of an otherwise rare allele is expected when Question 24 options: populations experienced disruptive selection populations were founded by a small number of settlers the allele is advantageous at the heterozygous state populations have higher than average mutation rates populations experienced stabilizing selectionarrow_forward5) This chart shows the fur colors of a population of rabbits in the Great Smoky Mountains. A mutation introduces an allele for white fur. Based on the data, what do you predict will happen in the next 20 years? Select ALL that apply. Not Graded A) Those with white fur will slowly increase over the next 20 years. B) Those with mottled fur and brown fur will continue to exist in the population. C) Those with white fur will continue to decrease or even die out of the population. D) Mottled fur is the dominant trait so it will continue to increase in the population. E) Unless the environment changes, those with mottled fur will continue to increase in number.arrow_forward
- A genetic mutation that causes deafness in humans has an autosomal recessive pattern of inheritance. In a study of a population of 235 Turkish children, 48 displayed the recessive phenotype. The frequency of the heterozygous genotype in the population of Turkish children described above is?arrow_forwardA mountain region has a population of 5,000 mountain goats. You score these animals for the R locus and find that this locus has two alleles, R (dominant) and r (recessive). 3200 individuals are homozygous dominant, 1,600 are heterozygous, and 200 are homozygous recessive. A deadly virus infects all of the RR mountain goats in the population (above), killing all individuals of this genotype and leaving the population with only the rr and Rr mountain goats. a) Calculate the new allele frequencies for this population. Show your work. b) Calculate the new (observed) genotypic frequencies for this population. Show your work. c) Does this population still appear to be at H-W equilibrium? Why or why not? (You do not need to analyze this statistically).arrow_forwardIn parts of equatorial Africa, where the malaria parasite is most common, the sickle-cell allele constitutes 20% of the ß-hemoglobin alleles in the human gene pool. The sickle cell trait provides an advantage against malaria compared to people with normal hemoglobin. In the United States, the parasite that causes malaria is not present, but African Americans whose ancestors were from equatorial Africa have the sickle-cell B- hemoglobin allele. These differences in traits illustrate O inclusive fitness because people have evolved molecular differences to adapt to environmental stimuli O inclusive fitness because ß-hemoglobin increases the proliferation of beneficial traits in the population O relative fitness because people have evolved molecular differences to an environmental pathogen O relative fitness because the molecular differences in ß-hemoglobin are passed to the next generationarrow_forward
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