The KM values for the reaction of chymotrypsin with two different substrates are given in the table below. Considering this information, which substrate has the lower apparent affinity for the enzyme? Which substrate is likely to give a lower value for Vmax? Substrate N-acetylvaline ethyl ester N-acetyltyrosine ethyl ester KM (M) 8.8 X 10-² 6.6 X 10-4 N-acetylvaline ethyl ester has the lower apparent affinity for the enzyme; it will also likely to give a lower Vmax. N-acetyltyrosine ethyl ester has the lower apparent affinity for the enzyme; it will also likely to give the lower Vmax. N-acetylvaline ethyl ester has the lower apparent affinity for the enzyme; N- acetyltyrosine ethyl ester is likely to give the lower Vmax. N-acetyltyrosine ethyl ester has the lower apparent affinity for the enzyme; N- acetylvaline will likely to give the lower Vmax. None of the above statements are correct.

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
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Chapter6: Oral Medication Labels And Dosage Calculation
Section: Chapter Questions
Problem 7.1P
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The KM values for the reaction of chymotrypsin with two different substrates are
given in the table below. Considering this information, which substrate has the
lower apparent affinity for the enzyme? Which substrate is likely to give a lower
value for Vmax?
Substrate
N-acetylvaline ethyl ester
N-acetyltyrosine ethyl ester
KM (M)
8.8 X 10-²
6.6 X 10-4
N-acetylvaline ethyl ester has the lower apparent affinity for the enzyme; it will
also likely to give a lower Vmax:
N-acetyltyrosine ethyl ester has the lower apparent affinity for the enzyme; it
will also likely to give the lower V₁
max.
N-acetylvaline ethyl ester has the lower apparent affinity for the enzyme; N-
acetyltyrosine ethyl ester is likely to give the lower Vmax:
N-acetyltyrosine ethyl ester has the lower apparent affinity for the enzyme; N-
acetylvaline will likely to give the lower Vmax.
None of the above statements are correct.
Transcribed Image Text:The KM values for the reaction of chymotrypsin with two different substrates are given in the table below. Considering this information, which substrate has the lower apparent affinity for the enzyme? Which substrate is likely to give a lower value for Vmax? Substrate N-acetylvaline ethyl ester N-acetyltyrosine ethyl ester KM (M) 8.8 X 10-² 6.6 X 10-4 N-acetylvaline ethyl ester has the lower apparent affinity for the enzyme; it will also likely to give a lower Vmax: N-acetyltyrosine ethyl ester has the lower apparent affinity for the enzyme; it will also likely to give the lower V₁ max. N-acetylvaline ethyl ester has the lower apparent affinity for the enzyme; N- acetyltyrosine ethyl ester is likely to give the lower Vmax: N-acetyltyrosine ethyl ester has the lower apparent affinity for the enzyme; N- acetylvaline will likely to give the lower Vmax. None of the above statements are correct.
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