You are a genetic analyst and you have a patient with inherited defects of glycolysis. Specifically, this patient has severe symptoms that stem from issues in their erythrocytes (red blood cells). You find that your patient has a deficiency in Hexokinase (HK).Given this information and keeping in mind what you learned about the steps of glycolysis, bisphosphoglycerate (BPG), and the importance of 2,3 BPG for hemoglobin oxygen binding what do you predict will be the effect of this mutation? Select all that apply.decreased 2,3BPG concentrationsreduced flow of metabolites through glycolysisincreased 2,3BPG concentrationsincreased flow of metabolites through glycolysisdecreased hemoglobin oxygen affinityincreased hemoglobin oxygen affinity000000

The first rate limiting step of glycolysis is catalyzed by hexokinase.The 2,3-diphosphoglycerate…

Answered: You are a genetic analyst and you have…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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TPI deficiency is a rare human condition. Patients who lack TPI cannot convert the triose dihydroxyacetone phosphate into glyceraldehyde 3-phosphate.What happens to glycolysis in TPI patients?TPI patients suffer from chronic hemolytic anemia (abnormal breakdown of red blood cells) and have variable neuromuscular dysfunctions, including muscle weakness, poor muscle tone, and atrophy. Most die of respiratory failure during childhood. Explain why TPI-deficient patients exhibit these conditions using the diagram to justify your answer. TPI is enzyme 5.G6PD deficiency is one of the most common human genetic conditions, affecting about 40 million people worldwide. Patients suffer from hemolytic anemia when exposed to certain drugs, viral or bacterial disease, or fava beans.
Statements:(1) Glucose 1-phosphate is an intermediate in both glycogenesis and glycogenolysis.(2) Conversion of ATP to ADP occurs in both steps one and three of glycolysis.(3) In the oxidative stage of the pentose phosphate pathway, a hexose phosphate is converted to a pentose phosphate and carbon dioxide. Group of answer choices All three statements are true. Two of the three statements are true. Only one of the statements is true. None of the statements are true.
Which carbons of glucose will be incorporated into Palmitic acid by the Fatty Acid Synthase? Multiple answers:Multiple answers are accepted for this question Select one or more answers and submit. For keyboard navigation...SHOW MORE a Carbon 1 b Carbon 2 c Carbon 3 d Carbon 4 e Carbon 5 f Carbon 6 g All carbons will be incorporated. h No carbons will be incorporated.
A 16-year-old female is recently diagnosed with a deficiency of muscle glycogen phosphorylase. She and her family are concerned and ask the following questions. Based on what you know about skeletal muscle glycogenolysis and muscle metabolism, please respond to each question with a thoughtful answer that describes the metabolism in these various scenarios in language that your patient will understand, while also being sure to include the role of the relevant metabolic pathways, specific enzymes, and stimulus for their activity: I’m not sure I understand the issue. Can you explain how muscle glycogen is used normally during exercise? I really like to take long walks; will Istill be able to do this with my friends? As a result of this deficiency, will I need to get up at night to eat to maintain my blood glucose levels? Do I need to worry about producing excessive lactate during intense anaerobic exercise?
Name: Hendric Nduwuba DNP and Cellular Respiration Summary https://www.youtube.com/watch?v=eLtRan2qFx0 Your assignment today is to summarize in two paragraphs (8 sentences total) the effects of dinitrophenol (DNP) on the human body. Make sure you explain what DNP is, the stages of cellular respiration, and how DNP alters the metabolism of the person using it (side effects). The following vocabulary terms need to be used: cellular respiration, adenosine triphosphate, and dinitrophenol (DNP). Your objective is to describe the role of ATP in cellular respiration in order to explain how DNP affects the rate of metabolism. The first paragraph is an introduction to the summary and the second paragraph is an explanation of the main idea. You will be graded on this criteria: main idea, explanation of cellular respiration, explanation of DNP, and paragraph structure.
Match the description with the correct enzyme. Descriptions: a. Uses alpha-keto carboxylic acid as a substrate b. Directly transfers cytosolic reducing equivalents into the electron transport chain c. Its activity depends on magnesium ions Options (enzymes): A. Mitochondrial glycerol 3-phosphate dehydrogenase B. Succinate dehydrogenase C. Cytosolic glycerol 3-phosphate dehydrogenase D. Cytochrome oxidase E. Rubisco F. α-ketoglutarate dehydrogenase complex
(b) The results in the table below were extracted from clinical reports of pediatric age infants (3 – 5 yr.) who had marked lactic acidosis, elevated blood ammonia, poor motor coordination, and showed mental retardation. From skin fibroblast cell cultures, enzyme assays were carried out, providing the results given below. PDH = pyruvate dehydrogenase; E1, E2, E3 signify the three enzyme activities of the PDH complex measured separately. It should be noted that measurement of the overall activity of the PDH complex employs a different assay system than those used for measurement of the activi- ties of the separate, individual component enzymes. Patient or PDH Complex activity nmol/min/mg protein Native E1 E2 Ез Control +dichloroacetate nmol/h/mg protein Patient 1 0.318 + 0.054 0.322 + 0.053 1.54 0.29 3.69 + 1.21 15.1 + 3.0 Patient 2 0.050 ± 0,031 0.044 + 0.027 0.21 + 0.06 6.5 ± 3.1 9.8 ± 1.3 Patient 3 0.092 + 0.022 0.068 + 0.037 0.21 + 0.06 8.48 13.5 + 2.0 Control 1 0.932 + 0.076 1.368…
Glycogen that is broken down in the muscle is not released as glucose into the circulation because the muscle lacks... Group of answer choices glucose-6-phosphatase phosphoryalse glycogen synthase hexokinase
The main location of ethanol metabolism in the body is the liver and the main route of detoxification includes liver alcohol dehydrogenases (ADH) located in the cytosol and aldehyde dehydrogenases (ALDH) located in the mitochondrion. Together these sequentially convert ethanol into acetate. A second (more minor) route of detoxification includes the microsomal ethanol oxidizing system (MEOS). 1. Based on the chemical structure, predict how permeable a biological membrane will be to ethanol (in the absence of a transporter/channel)?
Choose the best answers for each missing word from the list below. ____ regulated by ATP, Aspartate transcarbamoylase (ATCase) is (1) which is a (2)________________ regulator, and by CTP which binds to the (3)____ subunit of ATCase and shifts the conformational equilibrium to the (4). T state. CTP regulation of ATCase is called (5)________ 1) allosterically, 2) positive, 3) regulatory, 4) inactive, 5) feedback inhibition 1) covalently 2) positive, 3) regulatory, 4) active, 5) feedback inhibition 1) allosterically, 2) negative, 3) regulatory, 4) inactive, 5) feedforward activation 1) allosterically, 2) negative, 3) catalytic, 4) active, 5) feedforward inhibition 1) irreversibly, 2) positive, 3) catalytic, 4) inactive, 5) feedback inhihition
You have a crude lysate sample (CL) containing a mixture of six proteins (1, 2, 3, 4, 5, ẞ- galactosidase), and your goal is to obtain purified ẞ-gal. Some characteristics of these proteins are shown in the table below. Protein Alcohol dehydrogenase Carbonic anhydrase Insulin B chain Phosphorylase B Glutamic dehydrogenase B-galactosidase 45% Concentration of ammonium sulfate (AS) required for precipitation Molecular Weight (kDa) Isoelectric point (pl) 38 3.7 80% 65% 20% 30% 45% 28 4.8 4 5.3 98 6.8 49 9.5 115 5.3 You begin your purification by performing an ammonium sulfate (AS) precipitation. You add the appropriate concentration of AS to your CL sample, incubate overnight at 4°C, then centrifuge to generate a supernatant (AS-S) and pellet (AS-P). What concentration of AS will you use to precipitate Glutamic dehydrogenase? © 20% O 30% 45% 65% 80%
Name and explain in detail one pathological condition/state in which the activity of succinate dehydrogenase would decrease in human cells. You should describe the mechanism by which the condition/state affects the activity of enzyme.

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