Select all that apply Which of the following statements about 2,3-bisphosphoglycerate (2,3-BPG) areTRUE.2,3-BPG lowers the affinity of hemoglobin for oxygen.2,3-BPG stabilizes the T-state of hemoglobin.2,3-BPG has a lower affinity for HbF than for HbA.2,3-BPG can diffuse out of the RBC in the lungs, in order to allow oxygen to bindto hemoglobin and stabilize the R state.2,3-BPG lowers the affinity of myoglobin for oxygen.

Let's assess each statement to determine which ones are true:1. 2,3-BPG lowers the affinity of…

Answered: Which of the following statements about…

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter8: Blood

Section: Chapter Questions

Problem 3RQ

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Which of the following is incorrect about 2,3-bisphosphoglycerate (BPG)? It is highly (-) charged b. It prevents binding of O₂ to hemoglobin Oc. It binds only to the relaxed (oxy) conformation of hemoglobin Od. It binds in the space between the four subunits of hemoglobin a.
Which of the following proteins--when they become worn out--are responsible for the rupture of the RBC membrane? Select all that apply. spectrin hemoglobin carbonic anhydrase actin What happens to the heme portion of hemoglobin when a red blood cell dies? O it enters the small intestine where it is converted to bilirubin O it's converted to bilirubin which binds to albumin in the bloodstream O it's filtered by the kidneys and exits the body as urine O it's recycled and used to make hemoglobin for new cells
Which of the following statements regarding the transport of oxygen by hemoglobin is correct? Upon binding of oxygen to heme, a shift in the position of the distal His ultimately induces the switch from T to R states When fully bound to oxygen, AG(R-state)
Which of the following is TRUE about carbon dioxide binding to hemoglobin? Carbon dioxide carbamoylates the N-terminus, stabilizing the T-state Carbon dioxide binds to the central cavity in hemoglobin, stabilizing the T-state. Carbon dioxide, binds to the heme iron, stabilizing the T-state. None of the above are true. 1 UNANSWERED QUESTION 1/1 SKIP FOR NOW 14:03 / 14:11 MacBook Pro
Which of the following would you LEAST expect to be associated with a low hematocrit? High altitude Low iron Low vitamin B12 Low levels of erythropoietin Valine substitution for a glutamate in ß-hemoglobin
With the appearance of strong oxidizers in blood in erythrocytes one of the following substances is formed first of all: 1. carbhemoglobin 2. carboxyhemoglobin 3. oxyhemoglobin 4. methemoglobin 5. deoxyhemoglobin
Which of the following are true of normal adult hemoglobin? Choice 1 of 4:can bind four Fe2+ ions Choice 2 of 4:can covalently bind four O2 molecules Choice 3 of 4:can adopt 2 different conformations, with different orientations of αβ dimers Choice 4 of 4:can bind four BPG molecules to stabilize the T state
Place a single word into each sentence to make it correct saturation The relationship between hemoglobin and Po2 is shown by an oxyhemoglobin dissociation curve. rises lowers At low Po2, the curve slowly load When the curve rises there is a rapid increase in oxygen loading. deficiency When the first heme group binds a molecule of oxygen, changes conformation to accept a second carbon dioxide Oxygen. Eventually at high Po2 levels, the hemoglobin approaches 100 % saturation and can not hemoglobin more oxygen.
Crocodiles can use virtually 100% of the oxygen in its blood, whereas humans can extract only about 65% of the oxygen in their blood. Crocodile hemoglobin (Hb) binds HCO3, rather than 2,3-bisphosphoglycerate (BPG), when in the T-state. Which of the following best explains why HCO3¯ in the crocodile works better than 2,3-BPG in humans to help the Hb to release more of its bound oxygen? Crocodile Hb binds more oxygen than human Hb, and so the crocodile has more oxygen available than humans do. The [HCO3] varies with the amount of oxygen used, whereas the [BPG] in human erythrocytes is constant regardless of need. Humans require their hemoglobin to be sensitive to [BPG] in order for HbF (fetal Hb) to have a higher affinity for oxygen than maternal Hb. Since crocodile Hb binds HCO3, the HCO3 will not be available to bind to H+ (Bohr protons), and so more oxygen will be released to the tissues. Crocodiles are cold-blooded and so do not need as much oxygen as humans; this is why they can…
(b) The diagram on the right illustrates the change in the p50 (partial pressure of O2 required to achieve 50% saturation) of hemoglobin and the 2,3-bis-phosphoglycerate (BPG) concentration in the erythrocytes of a person who spent 6 days hik- ing in the Andes Mountains of Peru. As the hiker climbs to higher and higher altitudes, the atmos- pheric pressure, including the partial pressure of O2, decreases. Yet the p50 increases, making it less favorable to achieve saturation of the hemo- globin. Explain. Pso (torr) Sea level 34 33- 32 31 30- 29 28 27 26 4530 m above- sea level (c) If individuals with the following mutant hemo- globins accompanied the hiker, evaluate the degree of respiratory distress that they would experience despite the increased erythrocyte BPG concentration. (In the ta- ble of mutants on the right, the mutation His(143)Asp, for instance, means that the His residue that occurs at se- quence position 143 on the ß-chain has been substituted by Asp.) Describe the…
Hemoglobin will bind oxygen and release CO2 in places where there is a higher concentration of O2, lower concentration of CO2, lower temperature and lower acidity (as it is in lungs) and will do the reverse – release oxygen and bind CO2 - in places where there is a lower concentration of O2, higher concentration of CO2, higher temperature and higher acidity (as it is in working muscles). True False While white blood cells never leave the circulation, red blood cells regularly leave it and travel by lymphatic system or find home in other tissues, e.g., lymph nodes, spleen, etc. True False Blood clotting (coagulation) is a complex process involving many factors and it exhibits positive feedback loops: many of the factors also stimulate production of their own precursors. B lymphocytes mature in the thymus while T lymphocytes mature in the bone marrow True False Antibodies are molecules on the surfaces of foreign…
Referring to the loading and unloading of oxygen from hemoglobin (as illustrated in the figure), which of the following statements is correct? Oxygen Dissociation Curve.png Group of answer choices When a person in ventilating at rest, 75% of hemoglobin is still oxyhemoglobin The percent saturation of hemoglobin is higher at higher partial pressures of oxygen A decrease in the pH of the blood would promote unloading oxygen from the hemoglobin All of these are correct

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