Concept explainers
a)
Interpretation:
How to prepare the cyclohexanone shown by combining a Stork enamine reaction with an intramolecular aldol condensation is to be shown.
Concept introduction:
The steps involved in the reaction are i) Reaction of the cyclic
To give:
How to prepare the cyclohexanone shown by combining a Stork enamine reaction with an intramolecular aldol condensation.
b)
Interpretation:
How to prepare the cyclohexanone shown by combining a Stork enamine reaction with an intramolecular aldol condensation is to be shown.
Concept introduction:
The steps involved in the reaction are i) Reaction of the cyclic ketone with pyrrolidine ii) Michael addition of enamine to cyclohexanone iii) A proton transfer iv) Hydrolysis of the enamine to eliminate the amine v) Abstraction of a proton from the diketone vi) Internal aldol reaction to form the second ring vii) Protonation and dehydration.
To give:
How to prepare the cyclohexanone shown by combining a Stork enamine reaction with an intramolecular aldol condensation.
c)
Interpretation:
How to prepare the cyclohexanone shown by combining a Stork enamine reaction with an intramolecular aldol condensation is to be shown.
Concept introduction:
The steps involved in the reaction are i) Reaction of the cyclic ketone with pyrrolidine ii) Michael addition of enamine to cyclohexanone iii) A proton transfer iv) Hydrolysis of the enamine to eliminate the amine v) Abstraction of a proton from the diketone vi) Internal aldol reaction to form the second ring vii) Protonation and dehydration.
To give:
How to prepare the cyclohexanone shown by combining a Stork enamine reaction with an intramolecular aldol condensation.
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Chapter 23 Solutions
Organic Chemistry
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- How to synthesise 1-cyclohexylcyclohexanol from cyclohexanone?arrow_forwardThe Stork reaction is a condensation reaction between an enamine donor and an α,β-unsaturated carbonyl acceptor. The overall reaction consists of a three-step sequence of formation of an enamine from a ketone, Michael addition to an α,β-unsaturated carbonyl compound, and hydrolysis of the enamine in dilute acid to regenerate the ketone. Consider the Stork reaction between cyclohexanone and propenal Draw the structure of the product of the enamine formed between cyclohexanone and dimethylamine. - Michael addition to an α,β-unsaturated carbonyl compound, and - hydrolysis of the enamine in dilute acid to regenerate the ketone.arrow_forwardTreatment of a cyclic ketone with diazomethane is a method for accomplishing a ring-expansion reaction. For example, treatment of cyclohexanone with diazomethane yields cycloheptanone. Propose a mechanism.arrow_forward
- EBK A SMALL SCALE APPROACH TO ORGANIC LChemistryISBN:9781305446021Author:LampmanPublisher:CENGAGE LEARNING - CONSIGNMENT