The number of deuterium atoms that are expected to be attached to the dihydropyridine ring of NADH following enzymatic oxidation of each of the given isotopically labeled alcohols is to be determined. Concept Introduction: Isotopic labeling with deuterium helps in determining the mechanism of a reaction in which a proton is transferred from the reactant to the reagent. Isotopic labeling can be used to determine a reaction mechanism on the basis of whether the deuterium atom is retained in the product or is transferred to the reagent.

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Chapter 16.10, Problem 12P

Interpretation Introduction

Interpretation:

The number of deuterium atoms that are expected to be attached to the dihydropyridine ring of NADH following enzymatic oxidation of each of the given isotopically labeled alcohols is to be determined.

Concept Introduction:

Isotopic labeling with deuterium helps in determining the mechanism of a reaction in which a proton is transferred from the reactant to the reagent.

Isotopic labeling can be used to determine a reaction mechanism on the basis of whether the deuterium atom is retained in the product or is transferred to the reagent.

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