Sort the following steps of GPCR signal propagation (you may not use all the steps):A) Dephosphorylation of GPCRB) G protein dissociation to adenylate cyclase and GTP binds to the G proteinC) Ligand binding to GPCRD) G protein dissociation from GPCR and GDP binds to the G proteinE) Synthesis of CAMPF) Activation of PKAG) G protein association to adenylate cyclaseH) G protein dissociation from GPCR and GTP binds to the G proteinO F, C, H, F, BOCOB, D, A, E, HO C, H, G, E, FOA, G, H, B, E

G protein coupled receptors are protein receptors that are found closely associated with G proteins…

Answered: Sort the following steps of GPCR signal…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

With protein kinase-mediated molecular switches, downstream target molecules are typically activated by ... a) being phosphorylated b) binding to ATP c) the action of a phosphataase d) hydrolysis of GTP e) binding to GTP
Signaling by tyrosine kinase receptors is generally associated with all of the following except: A) receptor dimerization B) growth factor responses C) heterotrimeric G proteins D) cross phosphorylation E) generating protein binding sites due to phosphorylation
a line of cultured cells has a highly active Gs linked system that leads to persistent activation of adenyl cyclase. which of the following treatments is most likely to decrease signaling through this pathway. A) overexpression of G-alpha protein , B) overexpression of phosphodieterase, C) overexpression of ras protein, D) treatment with GTP, E) treatment with a protein kinase C agonist
Signaling by tyrosine kinase receptors is generally associated with all of the following except: OA) receptor dimerization B) growth factor responses C) heterotrimeric G proteins OD) cross phosphorylation E) generating protein binding sites due to phosphorylation
Which of the following does not involve a dimerization event? Explain why you chose, or did not choose, each answer. a) Transport of R-SMAD from the cytoplasm to the nucleus. b) Ligand binding to the EGF receptor c) CREB binding to the cAMP response element (CRE) d) Ligand binding to the TGF βreceptor
The p75 receptor differs from Trk receptors in that it a) can promote cell death. b) has high affinity for all neurotrophins. c) only binds a particular type of neurotrophin. d) can bind NGF to promote cell survival.
When the inhibitory Ga (Gia) protein is mutated and increases its intrinsic GTPase activity, a) Adenylate cyclase become more active b) Gia becomes more active c) Both a and b d) Neither a or b
Briefly describe the following properties of the Rab and Arf GTPases: a) Size, structure and cellular localization (for structure I want to know if they are lipidated and any other unique features) , b) How are they activated and inactivated (i.e. include the GEFs and GAPs), c). Give an example of downstream cellular effects.
The transforming growth factory beta (TGF-b) family of hormones / growth factors are dimers and they interact with specific receptors. Which of the following statements about these receptors is correct? a) A receptor complex is formed from a type 1 and a type 2 receptor b) A receptor complex is formed between the ligand and the receptor c) This family interacts with a single serine- threonine kinase receptor d) The major receptor is intracellular e) The receptor is a G-protein receptor
This inhibatory kinase phosphorylates an inactive M-Cdk. a) M-kinase b) Wee1 c) CAK d) Cdc25
12. Which statement regarding cell-surface receptors is correct? A) lon-channel-coupled receptors alter the membrane potential directly by changing the permeability of the plasma membrane. B) G-protein-coupled receptors are polypeptides with seven transmembrane domains. C) After binding their ligand, G-protein-coupled receptors interact with intracellular GTP-binding proteins, later initiating signal transduction events. D) All of the above E) None of the above Answer: Explanation:
Which of the following directly phosphorylate tyrosines to start a kinase protein enzymatic cascade? a) Receptor threonine kinase b) Receptor serine kinase c) Receptor tyrosine kinase d) Receptor guanylyl cyclases

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