Of the steps listed below, which problem would take you the longest to realize you had a problemin your RTK (ie the highest number of earlier steps could still occur)?O the RTK cannot autophosphorylateO the RTK cannot phosphorylate downstream kinasesthe RTK cannot integrate into the membranethe extracellular ligand cannot bind to the RTK

Receptor tyrosine kinases are abbreviated as RTKs.They constitute one class of transmembrane…

Answered: Of the steps listed below, which…

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 1VCQ: Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is...

See similar textbooks

Similar questions

Rous Sarcoma Virus can cause cancer in infected cells. The tumor causing nature of the virus is linked to it harbouring a gene that codes for a unique receptor tyrasine kinase (RTK). What is it about the tyrosine kinase that accounts for the tumor-causing nature of the virus? O It is unrelated to any human kinase and thus is able to act uncontrollably in causing cell division. O It cantain activate downstream effectors without binding to a SH2 domain. O It lacks the carboxy-terminal regulatory domain that is present in RTKS of non-cancerous cells.
You perform a competition study on a GPCR. You have isolated the plasma membrane from cells which contains the GPCR of interest. If an agonist and an inverse agonist are at equal concentrations in your study but the inverse agonist has a 10 x higher affinity for the receptor than the agonist, what would you expect to be the overall outcome to be? More of the agonist is bound and so most of the receptor is in its active conformation and is stimulated More of the inverse agonist is bound and so most of the receptor is in its inactive conformation and is unstimulated.
Which of the following are activated either directly or indirectly by a heterotrimeric G protein subunit (select all that apply)? O IP, receptor O PIP3-dependent protein kinase O Protein Kinase A O Akt O Phospholipase C O Adenylyl cyclase O Phosphoinositide 3-kinase
Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is permanently activated, resulting in unregulated cell division. Lapatinib, a drug used to treat breast cancer, inhibits HER2 receptor tyrosine kinase autophosphorylation (the process by which the receptor adds phosphates onto itself), thus reducing tumor growth by 50 percent. Besides autophosphorylation, which of the following steps would be inhibited by Lapatinib? Signaling molecule binding, dimerization, and the downstream cellular response. Dimerization, and the downstream cellular response. The downstream cellular response. Phosphatase activity, dimerization, and the downsteam cellular response.
Activation of the enzyme protein kinase C results from the binding of (select all that apply): OGq protein Ca²+ DAG IP 3 PIP2 Save for Later
Imagine that there is a mutation in the SRP receptor that disrupts its function. What is the logical outcome of this? Select all statements below that are true. Oa. SRP will no longer bind to the signal peptide O b. Membrane protein insertion will no longer occur correctly O c. SRP will no longer bind the SRP receptor O d. Vesicular movement from the ER to Golgi is inhibited O e. Proteins are no longer able to enter the secretory system
Ras activation can activate O MAP kinase O Protein kinase B Phospholipase C O Two of the above O All of the above
A protein kinase enzyme that is only active when complexed with cyclin is called OA OB. Cylin kinase enzyme Kinase dependent enzyme Cyclin dependent kinase Ос. OD. Kinase Cyclin Combination
Ligand binding of a (????) causes conformational changes in the receptor that free the associated G-protein to interact with other membrane proteins Voltage gated ion channel GPCR Ligand gated ion channel Ligandase pore
Cytokine receptors and tyrosine kinase receptors are similar in all of the following ways EXCEPT one. Which one is the exception? O They are both down-regulated by lysosomal degradation They both involve receptor exoplasmic domain dimerization They both result in an effector protein entering the nucleus O They both involve cytosolic domain phosphorylation
1. EGF interacts with blank to activate the MAP kinase cascade? G protein coupled receptor; receptor Tyrosine kinase; serine/threonine kinase; cdk 2. When a trimetric G protein is activated by gpcf? The three subuni8of the G protein remain tightly associated with each other; the GDP bound to the a subunit is phosphorylated to form bound GTP; it dissociates into a free b subunit as an ay subunit; none
Pay close attention to the information related to figure 3.14a and the structure of the PKA catalytic site in this figure. In a few well-written sentences, propose the following: A mutation that would result in PKA becoming a dead kinase*. A mutation that would result in PKA becoming a constitutively active** kinase.

SEE MORE QUESTIONS

Recommended textbooks for you

Biology 2e

Biology

ISBN:

9781947172517

Author:

Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:

OpenStax

Biology (MindTap Course List)

Biology

ISBN:

9781337392938

Author:

Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:

Cengage Learning

Biology 2e

Biology

ISBN:

9781947172517

Author:

Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:

OpenStax

Biology (MindTap Course List)

Biology

ISBN:

9781337392938

Author:

Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:

Cengage Learning

SEE MORE TEXTBOOKS