A major pathway for metabolism of ethanol is shown below. Humans consuming a large fraction of their calories in the form of ethanol may become hypoglycemic. This is because: Ethanol is a good solvent, and it dissolves the membranes of the mitochondria, where some of the gluconeogenic enzymes reside.   b. Ethanol metabolism indirectly inhibits pyruvate kinase, by consuming NAD.     d. Ethanol metabolism indirectly inhibits lactate dehydrogenase, by consuming NAD.     f. The assertion in the question is incorrect, because acetyl-CoA can be used for synthesis of glucose.   g. Ethanol metabolism indirectly inhibits pyruvate carboxylase, by consuming NAD.   h. Ethanol metabolism indirectly inhibits phosphoenolpyruvate carboxykinase, by consuming NAD.

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter23: Fatty Acid Catabolism
Section: Chapter Questions
Problem 13P
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A major pathway for metabolism of ethanol is shown below. Humans consuming a large fraction of their calories in the form of ethanol may become hypoglycemic. This is because: Ethanol is a good solvent, and it dissolves the membranes of the mitochondria, where some of the gluconeogenic enzymes reside.
 
b.
Ethanol metabolism indirectly inhibits pyruvate kinase, by consuming NAD.
 
 
d.
Ethanol metabolism indirectly inhibits lactate dehydrogenase, by consuming NAD.
 
 
f.
The assertion in the question is incorrect, because acetyl-CoA can be used for synthesis of glucose.
 
g.
Ethanol metabolism indirectly inhibits pyruvate carboxylase, by consuming NAD.
 
h.
Ethanol metabolism indirectly inhibits phosphoenolpyruvate carboxykinase, by consuming NAD.

 

OH
T
H₂C
Ethanol
CH3
NAD
NADH
Alcohol
dehydrogenase
H CH3
Acetaldehyde
FAD
FADH₂
Aldehyde
dehydrogenase
ATP
+ CoA-SH
CH3
Acetate
AMP
+ PPi
Acetyl-CoA
Synthetase 2
CoA-S CH3
Acetyl-CoA
Transcribed Image Text:OH T H₂C Ethanol CH3 NAD NADH Alcohol dehydrogenase H CH3 Acetaldehyde FAD FADH₂ Aldehyde dehydrogenase ATP + CoA-SH CH3 Acetate AMP + PPi Acetyl-CoA Synthetase 2 CoA-S CH3 Acetyl-CoA
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