Estimate KM and Vmax for the uninhibited reaction from the first graph. What difficulties do you find in getting accurate values? b. Make a Lineweaver-Burk (double reciprocal) plot to determine KM and Vmax again. What advantages do you see with the second method? c. Use the Lineweaver-Burk method and the table of data for the inhibitors to determine the kind of inhibition for each inhibitor.

Estimate KM and Vmax for the uninhibited reaction from the first graph. What difficulties do you find in getting accurate values? b. Make a Lineweaver-Burk (double reciprocal) plot to determine KM and Vmax again. What advantages do you see with the second method? c. Use the Lineweaver-Burk method and the table of data for the inhibitors to determine the kind of inhibition for each inhibitor.

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter9: Parenteral Medication Labels And Dosage Calculation

Section: Chapter Questions

Problem 7.7P

See similar textbooks

Similar questions

rug-B has an elimination half-life of 9 hours, an absorption half-life of 20 minutes and linear harmacokinetics. In a patient, the plasma concentration five hours from the administration of two 60 mg cablets of the drug is 8 ug/mL. What would you expect to be the plasma concentration five hours from the administration of one 60 mg tablets? 1 ug/mL Answer 1-1
PTP1B Substrate kcat Km. kcat/Km UM 10-7 x (s-1 M) DADEPYLIPQQG DADAPYLIPQQG DAAEP YLIPQQG AAAAPYLIPQQG 44.6 + 1.8 39.8 + 0.32 3.9 + 0.9 13.7 + 0.46 1.1 + 0.25 0.29 + 0.01 35.3 + 0.22 6.6 + 0.22 0.53 + 0.02 34.7 + 0.25 52.7 + 0.7 0.066 + 0.001 ) The units for kcat/KM in the above are given according to standard scientific notation. On this (d) ( basis what is the value of this kinetic parameter for the DADEPYLIPQQG substrate?
Cimetidine is used in the treatment and management of gastric ulcers and gastroesophageal reflux disease. In the case of an active ulcer, cimetidine can be administered continuous by IV infusion at a dose rate of 37.5 mg/hr. If the concentration of the cimetidine solution is 6 mg/ml, then how many milliliters must be available for a 4-hr infusion?Misoprostol is used to prevent NSAID-induced gastric ulcers. A daily dose consists of two tablets administered four times each day. What is the size of one day’s dose if each tablet contains 100 mcg of misoprostol?
Determine the Ki for the inhibitor at 30 °Cand decide what type of inhibitor is being used. Eo T I S V (g/I) (°C) (mmol/ml) (mmol/ml) (mmol/ml-min) 1.6 30 0.1 2.63 1.6 30 0.033 1.92 1.6 30 0.02 1.47 1.6 30 0.01 0.96 1.6 30 0.005 0.56 1.6 49.6 0.1 5.13 1.6 49.6 0.033 3.70 1.6 49.6 0.01 1.89 1.6 49.6 0.0067 1.43 1.6 49.6 0.005 1.11 0.92 30 0.1 1.64 0.92 30 0.02 0.90 0.92 30 0.01 0.58 0.92 30 0.6 0.1 1.33 0.92 30 0.6 0.033 0.80 0.92 30 0.6 0.02 0.57
Consider the following experimental data from another experiment: [S] 1.5 2.00 2.50 5.00 10.00 V (No inhibitor) mmol ml¹ min¹ 0.167 0.204 0.232 0.313 0.385 V (inhibitor) mmol ml¹¹ min¹¹ 0.115 0.143 0.167 0.250 0.333 Calculate Km and V max and determine whether this inhibitor is competitive, non-competitive or uncompetitive.
In the design of H2 antagonists, the polar guanidine group of compound A was proposed to interact with the antagonist binding region by two hydrogen bonds. This compelled researchers to derivatize compound B from compound A. HN EN Chain Extension Rigidification ZI compound A What drug design strategy has been used here? Simplification H₂N NH Substituent variation HN NH₂ HN NH N compound B
QUESTION 1 A. Define equilibrium constant of a drug B. Discuss the relationship between the equilibrium constant, affinity, potency and the response of a drug C. Discuss four factors that may affect a drug response
PTP1B Substrate kcat Km kcat/Km UM 10-7 x (s-1 M) DADEPYLIPQQG DADAPYLIPQQG DAAEPYLIPQQG AAAAPYLIPQQG 44.6 + 1.8 39.8 + 0.32 3.9 + 0.9 13.7 + 0.46 1.1 + 0.25 0.29 + 0.01 35.3 + 0.22 6.6 ± 0.22 0.53 + 0.02 34.7 + 0.25 52.7 ± 0.7 0.066 + 0.001 (d) (. ) The units for kcat/KM in the above are given according to standard scientific notation. On this basis what is the value of this kinetic parameter for the DADEPYLIPQQG substrate?
You have an order for 1 gram of Cefazolin in D5W 100 ml. You have added 5 ml of sterile water to the 1 gram vial to reconstitute powder. However the recommended manufacturer’s diluent amount is 10 ml of sterile water for a final concentration of 100 mg/ml. How would reconstituting the vial with 5 mls affect the concentration and the final calculated dose. Please answer with explanation ASAP. I will really upvote. Thanks
Doctors order Tazicef (ceftazidime) 1.5 g IV Q12H. Refer to the label below. How much Tazicef will you draw up for one dose? NDC 0409-5086-11 equivalent to 6 grams ceftazidime TAZICEF® Store at 20° to 25°C (68' to 7) (See USP Controled Room Temperaturel Primarily for institutional use. MPÓRTANT: This vial is under reduced pressure, Addition of diluent generates a positive pressure. Before reconstituting, see Instructions for Reconstitution. Usual Adult Dosage: 1 gram every 8 to 12 hours. Ih severe, refractory or Ite-threatening infections, 2 grams every 8 hours. See accompanying prescribing information. In two stages, add Sodium Chloride Injection, Sterile Water for Injection or Bacteriostatic Water for Injection according to table below. See accompanying prescribing information. SHAKE WELL, Use promptly. (Discard vial within 4 hours after initial entry.) Ceftazidime For Injection, USP Approx. Concentration Amount of Duent gram/5 ml 1 gram/10 mL 26 mL 56 mL 10 PHARMACY BULK VIALS NOT…
-Inhibitor +Inhibitor [S] (mM) Vη&νβσπ: (μmol/sec). ν0&νβσπ;&νβσπ:(μmol/sec) 0.0001 33 17 0.0005 71 50 0.001 83 67 0.005 96 91 0.01 98 95 What is the TYPE of iinhibitor?
Which of the following is incorrect about blood glucose test interpretation A) fasting plasma glucose 6.1-6.8 defined as having IGT and should probably be screened again after a year or so. B) 2 results>7mmmol/l defined as having diabetes C) fasting plasma glucose >6mmol, recall for further test. D) fasting or random plasma glucose, on one reading of <11.1mmol/l is diagnostic of diabetes