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A Brief Note On Coagulation Screening And Corrections Practical

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BS0504 Haematology and Transfusion Science
Practical Proforma
Semester 1 2014

Student Number: 13006788 Haematology Practical 1
Haemostasis: Coagulation Screening & Corrections Practical
Using the data generated in the practical session you will write a report below consisting of an:
Introduction - (10 marks) Introduce the utility of coagulation, the theory behind the tests and the clinical relevance of the tests.
Results- (10 marks) Present your data appropriately with normal ranges stated for all tests and the rational for attempting corrections.
Discussion/Conclusion- (25 Marks) Discuss the results that you have collated giving a possible clinical scenario for each patient AND HOW YOU ARRIVED AT THIS CONCLUSION (Including …show more content…

Significance - Meaning of high hba2
TF = 1.220
Absorbance of A2 elute = 0.137
5*1.220 = 6.1%
0.137/6.1 = 2.246 HbA2%
This result gives HbA2 of 2.246 suggesting the individual may not have the β-thalassemia trait hence normal or they could be β-thalassemia homozygous. The range for β-thalassemia homozygous is 2.8-3.5 and the range for normal individuals is 1.5-3.0. So this individual could be either as their, to find out if the patient has β-thalassemia or not, results from HbA2 must be taken in account with the patients history, total haemoglobin values and other lab tests.
2. What therapies are appropriate for a sufferer of Beta-Thalassaemia? (10 marks)
Individuals can be given regular blood transfusions, this has extended the life expectancy of individuals with Beta-Thalassaemia. Treatment maintains the patient’s haemoglobin at 9/10 g/dL and also treats the anaemia and suppresses endogenous erythropoiesis. However there are many problems associated with this treatment such as financial problems, also their quality of life changes, patients suffer from cardiac, endocrine and hepatic complications. http://search.proquest.com/docview/759558923?pq-origsite=summon
Haematopoietic stem cell transplantation (HSC) can be received, treatment is curable in some individuals that have thalassemia major. HSC has a high cure rate for both thalassemia patients that are class 1 and 2, but only works for those who are younger than 17 years of age, this treatment involves bone

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