Concept explainers
Derive the amino acid sequence that is coded for by each mRNA sequence.
- 5 CCA ACC UGG GUA GA,A 3
- 5 AUG UUU UUA UGG UGG 3
- 5 GUC GAC GAA CCG CAA 3
(a)
Interpretation:
Amino acid sequence responsible for the 5 CCA ACC UGG GUA GAA 3 mRNA code should be derived.
Concept Introduction:
Genetic code − DNA and RNA transform genetic information of the living cells through triplet code, which is a sequence of three nucleotides on DNA or RNA molecules codes for a specific amino acid in protein synthesis.
Answer to Problem 59P
Pro-Thr-Trp-Val-Glu
Explanation of Solution
Codons are written from 5 prime end (5) to 3 prime end (3) of mRNA. There is a unique triplet representation for a particular amino acid. Below mentioned table represent the relationship between nucleotides and amino acids.
The Genetic Code- Triplets in Messenger RNA
First Base (5' end) | Second Base | Third Base (3' end) | |||||||
U | C | A | G | ||||||
U | UUU | Phe | UCU | Ser | UAU | Tyr | UGU | Cys | U |
UUC | Phe | UCC | Ser | UAC | Tyr | UGC | Cys | C | |
UUA | Leu | UCA | Ser | UAA | Stop | UGA | Stop | A | |
UUG | Leu | UCG | Ser | UAG | Stop | UGG | Trp | G | |
C | CUU | Leu | CCU | Pro | CAU | His | CGU | Arg | U |
CUC | Leu | CCC | Pro | CAC | His | CGC | Arg | C | |
CUA | Leu | CCA | Pro | CAA | Gln | CGA | Arg | A | |
CUG | Leu | CCG | Pro | CAG | Gln | CGG | Arg | G | |
A | AUU | Ile | ACU | Thr | AAU | Asn | AGU | Ser | U |
AUC | Ile | ACC | Thr | AAC | Asn | AGC | Ser | C | |
AUA | Ile | ACA | Thr | AAA | Lys | AGA | Arg | A | |
AUG | Met | ACG | Thr | AAG | Lys | AGG | Arg | G | |
G | GUU | Val | GCU | Ala | GAU | Asp | GGU | Gly | U |
GUC | Val | GCC | Ala | GAC | Asp | GGC | Gly | C | |
GUA | Val | GCA | Ala | GAA | Glu | GGA | Gly | A | |
GUG | Val | GCG | Ala | GAG | Glu | GGG | Gly | G |
According to the above table; one amino acid has several triplets, but triplet code is unique for an amino acid.CCA triplet is unique for Proline.ACC triplet is unique for Threonine. UGG triplet is unique for Tryptophan.GUA triplet is unique for Valine.
Therefore, Pro-Thr-Trp-Val-Glu is the amino acid sequence for 5 CCA ACC UGG GUA GAA 3.
(b)
Interpretation:
Amino acid sequence responsible for the 5 AUG UUU UUA UGG UGG 3 mRNA code should be derived.
Concept Introduction:
Genetic code − DNA and RNA transform genetic information of the living cells through triplet code, which is a sequence of three nucleotides on DNA or RNA molecules codes for a specific amino acid in protein synthesis.
Answer to Problem 59P
Met-Phe-Leu-Trp-Trp
Explanation of Solution
Codons are written from 5 prime ends (5) to 3 prime ends (3) of mRNA. There is a unique triplet representation for a particular amino acid. The below-mentioned table represents the relationship between nucleotides and amino acids.
The Genetic Code- Triplets in Messenger RNA
First Base (5' end) | Second Base | Third Base (3' end) | |||||||
U | C | A | G | ||||||
U | UUU | Phe | UCU | Ser | UAU | Tyr | UGU | Cys | U |
UUC | Phe | UCC | Ser | UAC | Tyr | UGC | Cys | C | |
UUA | Leu | UCA | Ser | UAA | Stop | UGA | Stop | A | |
UUG | Leu | UCG | Ser | UAG | Stop | UGG | Trp | G | |
C | CUU | Leu | CCU | Pro | CAU | His | CGU | Arg | U |
CUC | Leu | CCC | Pro | CAC | His | CGC | Arg | C | |
CUA | Leu | CCA | Pro | CAA | Gln | CGA | Arg | A | |
CUG | Leu | CCG | Pro | CAG | Gln | CGG | Arg | G | |
A | AUU | Ile | ACU | Thr | AAU | Asn | AGU | Ser | U |
AUC | Ile | ACC | Thr | AAC | Asn | AGC | Ser | C | |
AUA | Ile | ACA | Thr | AAA | Lys | AGA | Arg | A | |
AUG | Met | ACG | Thr | AAG | Lys | AGG | Arg | G | |
G | GUU | Val | GCU | Ala | GAU | Asp | GGU | Gly | U |
GUC | Val | GCC | Ala | GAC | Asp | GGC | Gly | C | |
GUA | Val | GCA | Ala | GAA | Glu | GGA | Gly | A | |
GUG | Val | GCG | Ala | GAG | Glu | GGG | Gly | G |
According to the above table; one amino acid has several triplets, but triplet code is unique for an amino acid. AUG triplet is unique for Methionine. UUU triplet is unique for Phenylalanine.UUA triplet is unique for Leucine.UGG triplet is unique for Tryptophan.
Therefore, Met-Phe-Leu-Trp-Trp is the amino acid sequence for 5 AUG UUU UUA UGG UGG 3.
(c)
Interpretation:
Amino acid sequence responsible for the 5 GGG UGU AUG CAC CGA UUG 3 mRNA code should be derived.
Concept Introduction:
Genetic code − DNA and RNA transform genetic information of the living cells through triplet code, which is a sequence of three nucleotides on DNA or RNA molecules codes for a specific amino acid in protein synthesis.
Answer to Problem 59P
Val-Asp-Glu-Pro-Glu
Explanation of Solution
Codons are written from 5 prime ends (5) to 3 prime ends (3) of mRNA. There is a unique triplet representation for a particular amino acid. The below-mentioned table represents the relationship between nucleotides and amino acids.
The Genetic Code- Triplets in Messenger RNA
First Base (5' end) | Second Base | Third Base (3' end) | |||||||
U | C | A | G | ||||||
U | UUU | Phe | UCU | Ser | UAU | Tyr | UGU | Cys | U |
UUC | Phe | UCC | Ser | UAC | Tyr | UGC | Cys | C | |
UUA | Leu | UCA | Ser | UAA | Stop | UGA | Stop | A | |
UUG | Leu | UCG | Ser | UAG | Stop | UGG | Trp | G | |
C | CUU | Leu | CCU | Pro | CAU | His | CGU | Arg | U |
CUC | Leu | CCC | Pro | CAC | His | CGC | Arg | C | |
CUA | Leu | CCA | Pro | CAA | Gln | CGA | Arg | A | |
CUG | Leu | CCG | Pro | CAG | Gln | CGG | Arg | G | |
A | AUU | Ile | ACU | Thr | AAU | Asn | AGU | Ser | U |
AUC | Ile | ACC | Thr | AAC | Asn | AGC | Ser | C | |
AUA | Ile | ACA | Thr | AAA | Lys | AGA | Arg | A | |
AUG | Met | ACG | Thr | AAG | Lys | AGG | Arg | G | |
G | GUU | Val | GCU | Ala | GAU | Asp | GGU | Gly | U |
GUC | Val | GCC | Ala | GAC | Asp | GGC | Gly | C | |
GUA | Val | GCA | Ala | GAA | Glu | GGA | Gly | A | |
GUG | Val | GCG | Ala | GAG | Glu | GGG | Gly | G |
According to the above table; one amino acid has several triplets, but triplet code is unique for an amino acid. GUC triplet is unique for Valine. GAC triplet is unique for Aspartic acid. GAA triplet is unique for Glutamic acid. CCG triplet is unique for Proline. CAA triplet is unique for Glutamic acid.
Therefore, Val-Asp-Glu-Pro-Glu is the amino acid sequence for 5 GGG UGU AUG CAC CGA UUG 3.
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Chapter 22 Solutions
General, Organic, and Biological Chemistry - 4th edition
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