Concept explainers
Energetic of Fructose-1 ,6-bis P Hydrolysis (Integrates with Chapter 3.)
The standard free energy change (
6-bisphosphate (FBP) to fructose-S-phosphate (F-6-P) and P: is
-16.7 KJ/mol:
FBP + H2O
The standard free energy change (
-30.5 KJ/mol:
ATP + H2O
- What is the standard free energy change for the phosphofructokinase reaction:
ATP + fructose-6-P
b. What is the equilibrium constant for this reaction?
c. Assuming the intracellular concentrations of [ATP] and (ADP] are maintained constant at 4 mM and 1.6 mM, respectively, in a rat liver cell, what will be the ratio of [FBP]/[fructose-6-P] when the phosphofructokinase reaction reaches equilibrium?
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Chapter 18 Solutions
Biochemistry
- 6-25 substrate-band enzyme concentrations. The the turnover number is equal to umax- b) V=Umax •57(Km+S) anstont For an enzyme that displays Michaelis-Menten kinetics, what is the reaction velocity, V (as a percentage of Vmax), observed at the following values? a) [S] = KM C) d) e) [S] = 0.5KM [S] = = 0.1KM [S] = 2KM [S] = 10KM w reactores -maximumrate of reaction boteles conc. Would you expect the structure of a competitive inhibitor of a given enzyme to be similar to that of its substrate?arrow_forwardTracing the Fate of CO2 During Photosynthesis 14C-labeled carbon dioxide is administered to a green plant, and shortly thereafter the following compounds are isolated from the plant: 3-phosphoglycerate, glucose, erythrose-4-phosphate, sedoheptulose-1 .7-bisphosphate, and ribose-5-phosphate. In which carbon atoms will radioactivity be found?arrow_forwardnot true about the Michaelis-Menten equation? The equation that gives the rate, v, of an the substrate concentration [S] is the Michaelis-Menten equation = Vmax[S]/(Km + [S]), where V, enzyme-catalyzed reaction for all values of max and Km are constants. Which of the following is a) for [S] << Km, V = Vmax applies to most enzymes, but allosteric enzymes have different kinetics when [S] = Km, then v = Vmax/2 gives the rate when the enzyme concentration, temperature, pH, and ionic strength are constant for very high values of [S], v approaches Vmax e) Which is correct about the constant Km in the Michaelis-Menten equation? also called the catalytic constant or turnover number equal to the number of product molecules produced per unit time when the enzyme is saturated with substrate it is the constant in the first order rate equation v = k[A] it is the constant in the second order rate equation v = equal to the substrate concentration at which the velocity or rate of a reaction is ½ the…arrow_forward
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning