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The relationship between genotype of patients and concentration as well as
Given:
In the given study, the drug calm was administered to people whose SNPs were known and after 12 hours, blood samples were drawn to find the concentration of the drug. The three different SNPs with genotypes are: SNP 5689 (AA, AG, and GG), SNP 8835 (AA, AC, and CC), and SNP 11286 (TT, TG, and GG) as shown in Figure below. The letters (A, T, G, and C) stand for the type of nucleotide on the two homologous chromosomes.
Introduction:
The study of effectiveness of the drug based on information about individual genome or SNPs is called pharmacogenomics. The metabolism of calm depends on the genotype or SNP present in each individual.
Explanation of Solution
SNP 5869: The rate of metabolism and drug concentration after 12 hours of administration is correlated with different genotypes of SNP 5869. The metabolism of the drug is efficient in the people with genotype GG where the drug concentration in the blood is around 70. On the other hand, the drug concentration for the genotype AG is around 100 and it is around 130 for AA genotype. So, the genotype GG of SNP 5869 is associated with metabolizing the drug, calm efficiently.
SNP 8835: The rate of metabolism is high in the case of the genotype AA where the drug concentration is less, which is around 80. On the other hand, the rate of drug metabolism is less in the case of the genotype CC with drug concentration of around 120 and genotype AC where the concentration is around 100. So, the genotype AA of SNP 8835 is associated with metabolizing the drug, calm efficiently.
SNP 11286: The rate of metabolism is efficient for the genotype TT where the drug concentration is around 80. The rate of metabolism is less for the genotypes GG and TG where the drug concentration is 90 and 110, respectively. So, the genotype TT of SNP 11286 is associated with metabolizing the drug, calm efficiently.
Thus, efficiency and rate of drug metabolism depend on the genotypes where drug concentration is inversely proportional to the rate of metabolism.
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Chapter 17 Solutions
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