Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 1, Problem 1.2CC
You have discovered a defective gene that allows cancer cells to use glucose more efficiently and therefore outgrow normal cells to form a tumor. Explain how your discovery likely involves contributions from all three historical strands of cell biology.
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Describe the role of cell division in at least one of the following areas of biology:
Stem cell research
Cell cloning for organ replacement therapies
Cancer (see the DNA LC’s video on tumor growth for a hint: https://dnalc.cshl.edu/resources/3d/31-tumor-growth.html)
HeLa cells are a line of cells grown in laboratory culture that has been used extensively in research. This cell line was originally derived from malignant cervical cancer cells that were removed from a woman named Henrietta Lacks in 1951. They were grown in culture and shipped to research labs around the world where they have been used in many important experiments. Like HeLa cells, many other cell lines were originally taken from cancerous tissue. What are the advantages to using cancer cells for developing cell lines? Why not use normal tissue?
Chapter 1 Solutions
Becker's World of the Cell (9th Edition)
Ch. 1 - What evidence led scientists to develop the basic...Ch. 1 - Why is a high degree of antibody-antigen...Ch. 1 - You have discovered a defective gene that allows...Ch. 1 - Prob. 1.3CCCh. 1 - The Historical Strands of Cell Biology. For each...Ch. 1 - QUANTITATIVE Cell Sizes. To appreciate the...Ch. 1 - QUANTITATIVE Sizing Things Up. To appreciate the...Ch. 1 - Problem Set QUANTITATIVE Limits of Resolution Then...Ch. 1 - The Contemporary Strands of Cell Biology. For each...Ch. 1 - The Facts of Life. Each of these statements was...
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- Describe the role of cell division in at least one of the following areas of biology: Stem cell research Cell cloning for organ replacement therapies Cancerarrow_forwardCell division cycle mutations render the mutants unable to continue the cell cycle. This phenotype creates a paradox where mutant cells must also be grown in the lab to further identify the gene and study the role of the protein. How do you think this problem can be solved?arrow_forwardIdentify which of the following statements is a lie? Select one: a. Apoptosis occurs as the body produces certain enzymes that initiate degradation of nuclear and cytoplasmic material, breaking the cell into necrosis bodies. b. Apoptosis helps maintain a healthy and normal population of cells. c. Apoptosis plays an essential role in growth, immune surveillance, and embryological development.arrow_forward
- Tumor suppressor proteins can assist in slowing down the cell cycle under appropriate conditions. In humans, the TP53 gene encodes a tumor suppressor called p53. Most mutations in the TP53 gene result in a mutant form of p53 that can no longer function to slow down the cell cycle, which can lead to a cell becoming cancerous. However, some mutant forms of p53 actually possess the ability to increase a cell's resistance to anticancer treatments. Which of the following BEST describes the latter type of mutation? loss-of-function mutation gain-of-function mutation suppressor mutation reverse mutationarrow_forwardOne important biological effect of a large dose of ionizing radiation is to halt cell division. What might be the effects of such a mutation if the cell is not irradiated?arrow_forwardChemotherapy utilizes chemicals to interrupt various parts of the cell cycle, targeting rapidly growing cells. Taxol® is an example of a drug that prevents mitosis phase from occurring. How this Taxol useful as a cancer treatment and how might targeting rapidly growing cells explain common chemotherapy side effects such as hair loss and nausea? A. Taxol will stop the tumor from growing, but unfortunately it also impacts other fast-growing cells (like hair follicles and stomach lining cells), so normal cells get damaged as well. B. Taxol will stop the tumor from continuing to divide, but unfortunately it also impacts other readily dividing cells (like hair follicles and stomach lining cells), so normal cells get damaged as well. C. Taxol will stop the tumor from copying DNA, but unfortunately it also impacts DNA replication in other cells (like hair follicles and stomach lining cells), so normal cells don't get to continue through…arrow_forward
- Put a checkmark next to any of the following scenarios that would make it MORE likely that a cell would divide when it is not supposed to, increasing the chance that it would become cancerous. CHOOSE ALL THAT APPLY. A) A tumor suppressor gene is over-expressed B) A cyclin gene is mutated so that it is expressed at all times during the cell cycle C) A cyclin-dependent kinase gene is mutated so that in the Cdk is no longer dependent on its cyclin D) A Cdk gene is mutated so that the Cdk protein is not made E) Mutation of an oncogene that causes it to no longer be expressed F) A proto-oncogene gene is expressed at higher than normal levels G) The p53 gene is mutated so that no p53 protein is madearrow_forwardNew treatments for several conditions are being developed using stem cells in medical waste, such as biopsy material, teeth, menstrual blood, umbilical cords, and fatty tissue removed in liposuction. For example, fat samples from injured horses are used to grow stem cells to treat tendon injuries. Explain how the two defining characteristics of stem cells enable them to be used to replace damaged or diseased tissue, so that the new tissue functions as opposed to forming a scar.arrow_forwardIn your own words, explain how cancer cells differ from normal cells in regard to the following: Telomeres, which are products of telomerase enzymearrow_forward
- Explain the following figure. According to this model, what are the two major phases of metastasis that must be successful for metastasis? What are the challenges faced by cancer cells during metastatizing?arrow_forwardStem cells have the potential to transform into any of the various cell types in the body, and thus researchers have explored how stem cells may be used to treat different conditions. Which conditions benefit most from this treatment? At least 351 companies in the United States are now offering unapproved stem cell procedures at 570 clinics. If you had a serious illness such as Parkinson's disease and found an unregulated clinic that offered to cure your illness using stem cell therapy, would you accept the offer? What do you think is the reason that FDA and state medical boards are indifferent to those treatment; are unaware of the scope of the problem or simply are ignoring itarrow_forwardDiscuss the complete cell cycle in a human cell, mitosis and meiosis, and the regulatory components (i.e. the proteins associated with cellular checkpoints) of the cell cycle. Tumor growth results when the cell cycle checkpoints are ignored. Give an example of how tumor growth could result from either a loss-of-function or a gain-of-function mutation.arrow_forward
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The Cell Cycle and its Regulation; Author: Professor Dave Explains;https://www.youtube.com/watch?v=eqJqhA8HSJ0;License: Standard YouTube License, CC-BY
Cell Division - Mitosis and Meiosis - GCSE Biology (9-1); Author: Mr Exham Biology;https://www.youtube.com/watch?v=w7vp_uRA8kw;License: Standard YouTube License, CC-BY