qq. aldol reaction of acetone + sodium hydroxide 1. React the carbonyl compound: It is (circle one) CONJUGATED NON-CONJUGATED The Nucleophile is Potential to Establish a Resonance System Option 1: Almost all reactions Option 2 When Nu is a strong base ( OH or OR) 1 (Preferred) and the leaving group is identical to the Nu Nue Circle the option and reason Option 1: Always use UNLESS Option 2: (Remove the a H) The Nu matches Y AND is -OR 2. Take care of the negative formal charge of the oxygen in the tetrahedral complex Option 1 (Preferred): All cases except Option 2 1 (Preferred) Option 2: If there are no leaving groups, or if the only potential leaving group is the Nu that was just added and it is not a very good leaving group (N or O). Circle the option and reason Option 1: Always use UNLESS Option 2: There is no leaving group (there are only carbons and hydrogens), OR there are only carbons and hydrogens except for the Nu that just added, AND the Nu is N or O. If the double bond is reformed, what criterion is used to select the leaving group? (circle one) Shells Electronegativity EWA/Resonance Charge 3. If a hydrogen atom is added instead, does the reaction continue? Yes No Xs or 8- HÖ-H R 8- Nu
qq. aldol reaction of acetone + sodium hydroxide 1. React the carbonyl compound: It is (circle one) CONJUGATED NON-CONJUGATED The Nucleophile is Potential to Establish a Resonance System Option 1: Almost all reactions Option 2 When Nu is a strong base ( OH or OR) 1 (Preferred) and the leaving group is identical to the Nu Nue Circle the option and reason Option 1: Always use UNLESS Option 2: (Remove the a H) The Nu matches Y AND is -OR 2. Take care of the negative formal charge of the oxygen in the tetrahedral complex Option 1 (Preferred): All cases except Option 2 1 (Preferred) Option 2: If there are no leaving groups, or if the only potential leaving group is the Nu that was just added and it is not a very good leaving group (N or O). Circle the option and reason Option 1: Always use UNLESS Option 2: There is no leaving group (there are only carbons and hydrogens), OR there are only carbons and hydrogens except for the Nu that just added, AND the Nu is N or O. If the double bond is reformed, what criterion is used to select the leaving group? (circle one) Shells Electronegativity EWA/Resonance Charge 3. If a hydrogen atom is added instead, does the reaction continue? Yes No Xs or 8- HÖ-H R 8- Nu
Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter16: Synthesis Workshop 1
Section: Chapter Questions
Problem 32CTQ
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Follow direction. Do every step.
![qq. aldol reaction of acetone + sodium hydroxide
1. React the carbonyl compound:
It is (circle one) CONJUGATED
NON-CONJUGATED
The Nucleophile is
Potential to Establish a Resonance System
Option 1: Almost all reactions
Option 2: When Nu is a strong base (OH or OR),
1 (Preferred)
and the leaving group is identical to the Nu
NUB
Circle the option and reason
Option 1: Always use UNLESS
Option 2: (Remove the a H)
The Nu matches Y AND is -OR
2. Take care of the negative formal charge of the oxygen in the tetrahedral complex
Option 1 (Preferred): All cases except Option 2
1 (Preferred)
Option 2: If there are no leaving groups,
or if the only potential leaving group is
the Nu that was just added and it
is not a very good leaving group (N or O).
Circle the option and reason
Option 1: Always use UNLESS
Option 2: There is no leaving group (there are
only carbons and hydrogens), OR there are only
carbons and hydrogens except for the Nu that
just added, AND the Nu is N or O.
If the double bond is reformed, what criterion is used to select the leaving group? (circle one)
Shells
Electronegativity
EWA/Resonance
Charge
3. If a hydrogen atom is added instead, does the reaction continue? Yes No
Xs or
8- H0-H
R-
6+
-R
8- Nu](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F37a1fddf-e83d-4d78-92bc-9cc1b7d49324%2F86f7054d-9a7f-412b-8792-56f50be6519e%2Fvzctm07_processed.jpeg&w=3840&q=75)
Transcribed Image Text:qq. aldol reaction of acetone + sodium hydroxide
1. React the carbonyl compound:
It is (circle one) CONJUGATED
NON-CONJUGATED
The Nucleophile is
Potential to Establish a Resonance System
Option 1: Almost all reactions
Option 2: When Nu is a strong base (OH or OR),
1 (Preferred)
and the leaving group is identical to the Nu
NUB
Circle the option and reason
Option 1: Always use UNLESS
Option 2: (Remove the a H)
The Nu matches Y AND is -OR
2. Take care of the negative formal charge of the oxygen in the tetrahedral complex
Option 1 (Preferred): All cases except Option 2
1 (Preferred)
Option 2: If there are no leaving groups,
or if the only potential leaving group is
the Nu that was just added and it
is not a very good leaving group (N or O).
Circle the option and reason
Option 1: Always use UNLESS
Option 2: There is no leaving group (there are
only carbons and hydrogens), OR there are only
carbons and hydrogens except for the Nu that
just added, AND the Nu is N or O.
If the double bond is reformed, what criterion is used to select the leaving group? (circle one)
Shells
Electronegativity
EWA/Resonance
Charge
3. If a hydrogen atom is added instead, does the reaction continue? Yes No
Xs or
8- H0-H
R-
6+
-R
8- Nu
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