Fatty acids are converted to their coenzyme A esters in a reversible reaction catalyzed by acyl-CoA synthetase: R-COO +ATP +COA R-C-CoA + AMP + PPi a) The reaction involves two steps the first of which forms an enzyme-bound intermediate identified as the mixed anhydride of the fatty acid and AMP: R-C-O-P-O-nbose-adenine Wite two chemical equations corresponding to the two steps of the reaction catalyzed by the synthetase.

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter23: Fatty Acid Catabolism
Section: Chapter Questions
Problem 21P: Using the ActiveModel for enoyl-CoA dehydratase, give an example of a case in which conserved...
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Fatty acids are converted to their coenzyme A esters in a reversible reaction catalyzed by acyl-CoA
synthetase:
R-COO +ATP +COA R-C-COA +AMP + PPi
a) The reaction involves two steps the first of which forms an enzyme-bound intermediate identified as the
mixed anhydride of the fatty acid and AMP:
R-C-O-P-O-nibose-adenine
Write two chemical equations coresponding to the two steps of the reaction catalyzed by the synthetase.
b) The acyl-CoA synthetase reaction as written above is readily reversible. How might the reaction be made
to favor formation of fatty acyl-CoA? Write within the box. Anything outside the box will not be graded.
From the
Transcribed Image Text:Fatty acids are converted to their coenzyme A esters in a reversible reaction catalyzed by acyl-CoA synthetase: R-COO +ATP +COA R-C-COA +AMP + PPi a) The reaction involves two steps the first of which forms an enzyme-bound intermediate identified as the mixed anhydride of the fatty acid and AMP: R-C-O-P-O-nibose-adenine Write two chemical equations coresponding to the two steps of the reaction catalyzed by the synthetase. b) The acyl-CoA synthetase reaction as written above is readily reversible. How might the reaction be made to favor formation of fatty acyl-CoA? Write within the box. Anything outside the box will not be graded. From the
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