Aminolevulinate (ALA) synthase is a pyridoxal phosphate containing enzyme displaying a non-sequential (ping-pong) enzyme mechanism. It catalyses the reaction: glycine + succinyl-CoA ⇌ aminolevulinate + CO2 Draw a Cleland diagram (diagram illustrating when the substrates and products form an enzyme substrate complex) for this reaction if glycine is the first substrate to bind.

Aminolevulinate (ALA) synthase is a pyridoxal phosphate containing enzyme displaying a non-sequential (ping-pong) enzyme mechanism. It catalyses the reaction: glycine + succinyl-CoA ⇌ aminolevulinate + CO2 Draw a Cleland diagram (diagram illustrating when the substrates and products form an enzyme substrate complex) for this reaction if glycine is the first substrate to bind.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter23: Fatty Acid Catabolism

Section: Chapter Questions

Problem 21P: Using the ActiveModel for enoyl-CoA dehydratase, give an example of a case in which conserved...

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Aminolevulinate (ALA) synthase is a pyridoxal phosphate containing enzyme displaying a non-sequential (ping-pong) enzyme mechanism. It catalyses the reaction: glycine + succinyl-CoA ⇌ aminolevulinate + CO2 (A) Sketch the Lineweaver Burke plots for ALA synthase varying glycine at three (3) different fixed concentrations of succinyl-CoA. Label the axes and the lines, and explain in words what you expect to see for these three lines. (B) Draw a Cleland diagram (diagram illustrating when the substrates and products form an enzyme substrate complex) for this reaction if glycine is the first substrate to bind.
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