If one were to ingest ethanol labeled with 1C at the methyl carbon, where would that carbon belost as CO2? Ethanol is converted into acetyl COA by oxidation of the alcohol, first toacetaldehyde, then to acetate followed by activation to form acetyl CoA.For the following answers, the first round refers to the round of the CAC immediately upon entryby the acetyl CoA.O In the first round exclusively at isocitrate dehydrogenasein the first round exclusively at a-ketoglutarate dehydrogenasein the second round exclusively at isocitrate dehydrogenaseO in the second round exclusively at a-ketoglutarate dehydrogenaseO in the second round at either isocitrate dehydrogenase or aketoglutarate dehydrogenaseO in the third round exclusively at isocitrate dehydrogenaseO in the third round exclusively at a-ketoglutarate dehydrogenaseOit will not be lost until at least the third round with loss possible at either isocitrate dehydrogenase or aketoglutarate dehydrogenase

Ethanol is converted to acetyl CoA, with labelled methyl carbon.

If one were to ingest ethanol labeled with 1C at the methyl carbon, where would that carbon be lost as CO,? Ethanol is converted into acetyl CoA by oxidation of the alcohol, first to acetaldehyde, then to acetate followed by activation to form acetyl CoA. For the following answers, the first round refers to the round of the CAC immediately upon entry by the acetyl CoA. O In the first round exclusively at isocitrate dehydrogenase O in the first round exclusively at a-ketoglutarate dehydrogenase O in the second round exclusively at isocitrate dehydrogenase O in the second round exclusively at a-ketoglutarate dehydrogenase O in the second round at either isocitrate dehydrogenase or arketoglutarate dehydrogenase O In the third round exclusively at isocitrate dehydrogenase O In the third round exclusively at aketoglutarate dehydrogenase Oit will not be lost until at least the third round with loss possible at either isocitrate dehydrogenase or a ketoglutarate dehydrogenase

If one were to ingest ethanol labeled with 1C at the methyl carbon, where would that carbon be lost as CO,? Ethanol is converted into acetyl CoA by oxidation of the alcohol, first to acetaldehyde, then to acetate followed by activation to form acetyl CoA. For the following answers, the first round refers to the round of the CAC immediately upon entry by the acetyl CoA. O In the first round exclusively at isocitrate dehydrogenase O in the first round exclusively at a-ketoglutarate dehydrogenase O in the second round exclusively at isocitrate dehydrogenase O in the second round exclusively at a-ketoglutarate dehydrogenase O in the second round at either isocitrate dehydrogenase or arketoglutarate dehydrogenase O In the third round exclusively at isocitrate dehydrogenase O In the third round exclusively at aketoglutarate dehydrogenase Oit will not be lost until at least the third round with loss possible at either isocitrate dehydrogenase or a ketoglutarate dehydrogenase

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter29: The Organic Chemistry Of Metabolic Pathways

Section29.SE: Something Extra

Problem 52AP

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