Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Videos
Question
Chapter 8.4, Problem 18CC
Summary Introduction
To determine: The advantage of the specificity of drugs for a particular subtype of receptors.
Introduction: A particular pharmaceutical company designs the drugs according to the specificity of drugs for their receptors. The specificity of the drugs for their receptors and targets is very crucial for the proper functioning of the drugs.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
What are the receptor(s) involved in caffeine binding?What kind of interaction is established between them,based on the four types of receptors below:
Voltage Gated Ion Channels
G-protein coupled receptor
Enzyme-linked receptor
Intracellular receptor
Aducanumab is a human antibody treatment strategy currently undergoing phase III clinical trials in Alzheimer’s disease. This acts by: (choose all that apply)
increasing cholinergic stimulation
selectively inhibiting serotonin
stimulating dopamine receptors
reducing the production of Aβ plaques
promoting neurogenesis
reducing neurofibrillary tangles
What is the mechanism of LTP expression?
Select one:
a. Increase in the number of postsynaptic NMDA receptors
b. Increase in the intracellular level of proteins involved in synaptic release
c. Increase in the number of postsynaptic AMPA receptors
d. Increase in the number of presynaptic AMPA receptors
e. Decrease in the level of glutamate released into the synaptic cleft
Chapter 8 Solutions
Human Physiology: An Integrated Approach (8th Edition)
Ch. 8.1 - Organize the following terms describing functional...Ch. 8.2 - Where do neurohormone-secreting neurons terminate?Ch. 8.2 - What is the difference between a nerve and a...Ch. 8.2 - Draw a chain of three neurons that synapse on one...Ch. 8.2 - What is the primary function of each of the...Ch. 8.2 - Name the two glial cell types that form myelin....Ch. 8.3 - Given the values in Table 8.2, use the Nernst...Ch. 8.3 - Would a cell with a resting membrane potential of...Ch. 8.3 - Would the cell membrane depolarize or...Ch. 8.3 - Match each ions movement with the type of graded...
Ch. 8.3 - Prob. 11CCCh. 8.3 - What is the difference between conductance and...Ch. 8.3 - If you put ouabain, an inhibitor of the Na+-K+...Ch. 8.3 - The pyrethrin insecticides, derived from...Ch. 8.3 - When Na+ channel gates are resetting, is the...Ch. 8.3 - A stimulating electrode placed halfway down an...Ch. 8.3 - Place the following neurons in order of their...Ch. 8.4 - Prob. 18CCCh. 8.4 - Prob. 19CCCh. 8.4 - Prob. 20CCCh. 8.4 - Prob. 21CCCh. 8.4 - Prob. 22CCCh. 8.4 - Classify the H+-neurotransmitter exchange as...Ch. 8.4 - Prob. 24CCCh. 8.4 - Prob. 25CCCh. 8.4 - Is Na+-dependent neurotransmitter reuptake...Ch. 8.5 - In Figure 8.24e, assume the postsynaptic neuron...Ch. 8.5 - In the graphs of Figure 8.24a, b, why doesnt the...Ch. 8.5 - Prob. 29CCCh. 8.5 - Prob. 30CCCh. 8 - List the three functional classes of neurons, and...Ch. 8 - Somatic motor neurons control __________, and...Ch. 8 - Prob. 3RQCh. 8 - Prob. 4RQCh. 8 - Prob. 5RQCh. 8 - Prob. 6RQCh. 8 - Axonal transport refers to the (a) release of...Ch. 8 - Match the numbers of the appropriate...Ch. 8 - Arrange the following events in the proper...Ch. 8 - List the four major types of ion channels found in...Ch. 8 - Prob. 11RQCh. 8 - An action potential is (circle all correct...Ch. 8 - Choose from the following ions to fill in the...Ch. 8 - What is the myelin sheath?Ch. 8 - List two factors that enhance conduction speed.Ch. 8 - Prob. 16RQCh. 8 - Draw and label a graph of an action potential....Ch. 8 - Prob. 18RQCh. 8 - Prob. 19RQCh. 8 - Create a map showing the organization of the...Ch. 8 - Prob. 21RQCh. 8 - Prob. 22RQCh. 8 - Prob. 23RQCh. 8 - Prob. 24RQCh. 8 - The presence of myelin allows an axon to (choose...Ch. 8 - Define, compare, and contrast the following...Ch. 8 - Prob. 27RQCh. 8 - Prob. 28RQCh. 8 - Prob. 29RQCh. 8 - Prob. 30RQCh. 8 - An unmyelinated axon has a much greater...Ch. 8 - The GHK equation is sometimes abbreviated to...Ch. 8 - In each of the following scenarios, will an action...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- The drug Celebrex selectively inhibits PTGS2 while aspirin and other NSAID’s inhibit both PTGS1 and PTGS2 in the same way. Why do you think researchers wanted to discover a selective inhibitor to PTGS2?arrow_forwardArrange the following in correct order in which G-protein coupled receptor systems are activated: Drug Receptor Protein kinase A Adenylyl cyclase G-protein Cellular responsearrow_forwardWhat will be the receptor probability of the active state after you add a high dose of an antagonist?arrow_forward
- Why is it that muscarinic ACh receptors can depolarize some cells and hyperpolarize others? There are different muscarinic ACh receptor subtypes - they are ionotropic receptors and activate different signaling pathways. O There are different muscarinic ACh receptor subtypes - they are ionotropic receptors and open different ion channels. There are different muscarinic ACh receptor subtypes - they are metabotropic receptors and activate different signaling pathways. There are different muscarinic ACh receptor subtypes - they are metabotropic receptors and open different ion channels. None of the above - muscarinic ACh receptors can only depolarize cellsarrow_forwardEXPLAIN THE RECEPTOR THEORY AND THE FOUR RECEPTOR FAMILIES. WHAT CLASS OF MEDICATION IS VERAPAMIL, AND HOW DOES IT WORK?arrow_forwardBuprenorphine is a partial agonist at mu opioid receptors and is used for opioid maintenance treatment (OMT) in patients with opioid use disorder (OUD). Buprenorphine is formulated in a product that contains the mu opioid receptor antagonist, naloxone. What is the purpose of naloxone in this formulation? O To increase the magnitude of response to the partial agonist. O To reduce the likelihood that buprenorphine will be injected intravenously. O To delay the response to buprenorphine. O To provide pain relief to the patient who has OUD.arrow_forward
- Why are there multiple receptor subtypes for eachneurotransmitter? Why not a few receptors and lots ofneurotransmitters acting on each receptor?arrow_forwardWhich of the following statements most accurately describes what happens when an antagonist binds to a receptor? The antagonist binds non-covalently to the receptor and promotes internalisation of the receptor. Antagonist binding alters the structure of the receptor making it unable to function normally. At sufficiently high concentrations the antagonist can prevent the receptor from binding to its natural (endogenous) ligand. The antagonist-receptor complex binds to a heterotrimeric G protein forming a stable and inactive ternary complex.arrow_forwardWhat is the benefit of having different types of adrenergic receptors in the body? What is e.g. specific to beta-2 receptors?arrow_forward
- In relation to Cushing’s Syndrome, a method that some scientists have used to treat the disease is to use small molecules that bind to, but do not activate, MC2R. This type of molecule is considered an antagonist. How can an antagonist bind to the same receptor as ACTH but not activate it ? a. The antagonist binds covalently while ACTH binds non covalently b. The antagonist is only partially complimentary to the binding pocket of MC2R c. The antagonist binds to ACTH and blocks it from binding to the receptor properly d. The antagonist is the exact same structure as ACTH but since it is synthetic it doesn’t workarrow_forwardDopamine is a major neurotransmitter in the mammalian brain that regulates mood, cognition and locomotion. Which of the following are true about dopamine signaling in the synapse? Select all that apply. Presynaptic nerve cell Dendrites Axon Nerve impulse Myelin sheath Nerve impulse Neuro- transmitter Synapse Postsynaptic nerve cell Postsynaptic receptors Dopamine receptors are localized in the presynaptic membrane Action potential in presynaptic axon terminal results in the opening of chloride channels Dopamine receptors are localized in the postsynaptic membrane Action potential in presynaptic axon terminal results in the opening of calcium channelsarrow_forwardexplain what does hisatmine and adetycholine mimic. within smooth muscle receptors. what do they bind and what do they activate.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
Nervous System - Get to know our nervous system a bit closer, how does it works? | Neurology; Author: FreeMedEducation;https://www.youtube.com/watch?v=6O-0CVAgaEM;License: Standard youtube license