Microbiology: An Evolving Science (Fourth Edition)
Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 28.3, Problem 1TQ
Summary Introduction

To review:

The process to determine the source of nosocomial infection with MRSA in the provided case.

Introduction:

Methicillin-resistant of Staphylococcus aureus (MRSA) is a bacterium which belongs to Gram-positive bacteria and is responsible for causing a number of infections in the body. Treatment for this strain is tougher when compared to other strains of Staphylococcus aureus because they are resistant to antibiotics that are commonly used. The symptoms of MRSA change depending on the part it infects.

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Assume you work at the local hospital in your home town.  Suddenly you notice that 10% of your patients are having serious staphylococcal infections.  None of these patients were admitted for having a staphylococcal infection, and we assume that all standard infectious control procedures are being followed (hand washing, use of gloves and masks, etc.).  Remember that a small percentage of bacteria do evade even the most scrupulous of infectious disease control procedures.  How could you use what you have learned in this week’s laboratory to solve the problem? How could you find out where the infection originated?  What steps would you need to take? How could you determine definitively what organism is causing these patients’ infections?   How could you determine how to treat these patients?  Once you determine the source of the infection, what ethical issues, if any, are involved here?  What should you do to protect the privacy and welfare of the patients as well as avoiding conduct…
In 2013, there was an outbreak of methicillin-resistant Staphylococcusaureus (MRSA) at an NFL training facility. One player suffereda career-ending infection to his foot and sued the team owners for $20 million for unsanitary conditions that contributed to the bacterialinfection. A settlement with undisclosed terms was reached in2017. MRSA is highly contagious and is spread by direct skin contactor by airborne transmission and can result in amputation or death.In addition, MRSA is very difficult to treat because it is resistant tomany antibiotics. For example, b -lactam antibiotics, such as penicillin,function by binding to and inactivating bacterial penicillin-bindingproteins (PBPs), which synthesize the bacterial cell wall. However,MRSA expresses an alternative type of PBP, called PBP2a encodedby the mecA gene. b -lactam antibiotics only weakly bind PBP2a,and thus cell wall synthesis can continue in their presence. Moreover,in a system somewhat analogous to the regulation of the…
In 2013, there was an outbreak of methicillin-resistant Staphylococcusaureus (MRSA) at an NFL training facility. One player suffereda career-ending infection to his foot and sued the team owners for $20 million for unsanitary conditions that contributed to the bacterialinfection. A settlement with undisclosed terms was reached in2017. MRSA is highly contagious and is spread by direct skin contactor by airborne transmission and can result in amputation or death.In addition, MRSA is very difficult to treat because it is resistant tomany antibiotics. For example, b -lactam antibiotics, such as penicillin,function by binding to and inactivating bacterial penicillin-bindingproteins (PBPs), which synthesize the bacterial cell wall. However,MRSA expresses an alternative type of PBP, called PBP2a encodedby the mecA gene. b -lactam antibiotics only weakly bind PBP2a,and thus cell wall synthesis can continue in their presence. Moreover,in a system somewhat analogous to the regulation of the…
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Bacterial Infections in Humans; Author: Professor Dave Explains;https://www.youtube.com/watch?v=FeFKAl9KyMg;License: Standard Youtube License