Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Textbook Question
Chapter 28, Problem 19P
Figure 28.11 depicts the eukaryotic cell cycle. Many cell types “exit� the cell cycle and don’t divide for prolonged periods, a state termed
a. In what stage of the cell cycle do you suppose a cell might be when it exits the cell cycle and enters
b. The cell cycle is controlled by checkpoints, cyclins, and CDKs. Describe how biochemical events involving cyclins and CDKs might control passage of a dividing cell through the cell cycle.
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1. (a) Describe the generalized model of the cell cycle. Demonstrate how cyclins and cyclin-dependent kinases can regulate the cell cycle.
(b). Describe three ways in which cells lose their ability to regulate their growth to become cancerous.
Which of the following is least likely to result in the formation of a cancerous cell?
A Dysfunction results in the permanent activation of a cell division pathway in the absence
of the appropriate ligand.
B
с
D
Separation of chromatids during mitosis occurs without all centromeres being attached
to spindle fibers from both poles.
A dysfunction in a cell cycle checkpoint prevents a cell from entering the S phase.
A dysfunction causes the inability to produce cancer-suppressing proteins.
BPA is a chemical compound that has historically been used in themanufacture of plastic products. However, cells often mistake BPAcompounds for hormones that accelerate the cell cycle. Because ofthis, BPA is associated with an increased risk of certain cancers.
Question: How might BPA interact with the cell cycle and its checkpoints?
Chapter 28 Solutions
Biochemistry
Ch. 28 - Semiconservative or Conservative DNA Replication...Ch. 28 - The Enzymatic Activities of DNA Polymerase I (a)...Ch. 28 - Multiple Replication Forks in E. coli I Assuming...Ch. 28 - Multiple Replication Forks in E. coli II On the...Ch. 28 - Molecules of DNA Polymerase III per Cell vs....Ch. 28 - Number of Okazaki Fragments in E. coli and Human...Ch. 28 - The Roles of Helicases and Gyrases How do DNA...Ch. 28 - Human Genome Replication Rate Assume DNA...Ch. 28 - Heteroduplex DNA Formation in Recombination From...Ch. 28 - Homologous Recombination, Heteroduplex DNA, and...
Ch. 28 - Prob. 11PCh. 28 - Prob. 12PCh. 28 - Chemical Mutagenesis of DNA Bases Show the...Ch. 28 - Prob. 14PCh. 28 - Recombination in Immunoglobulin Genes If...Ch. 28 - Helicase Unwinding of the E. coli Chromosome...Ch. 28 - Prob. 17PCh. 28 - Functional Consequences of Y-Family DNA Polymerase...Ch. 28 - Figure 28.11 depicts the eukaryotic cell cycle....Ch. 28 - Figure 28.41 gives some examples of recombination...Ch. 28 - Prob. 21PCh. 28 - Prob. 22P
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
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- Normal Cell Cycle Describe the cell cycle using the following words: 1. Interphase 2. G1 1 3. G2 4. S phase 5. Mphase (mitosis) 6. Prophase 7. Metaphase 8. Anaphase 9. Telophase 10. Cytokinesis 11. Apoptosis 12. Check Points feedbackarrow_forwardPassage of cells from G1 through R to S depends on the interaction of various signal molecules, proteins and enzymes which regulate the cell cycle. Imagine I have just induced a mutation in a cell line which prevents the breakdown of the cyclin molecule we discussed. Which of the following events do you predict will happen? circle all that apply Select one or more: a. Uncontrolled cell replication may result b. Retinoblastoma protein will be continuously active c. The cells will be stuck in G1 phase d. The cells will begin to replicate their DNA e. Cyclin dependent kinase (Cdk) will be continuously activearrow_forwardCell growth and division occurin a regular cycle. This cycle is divided into four phases: G1, S, G2, and M. The diagram sh ows this cycle, alongwith events that occur in each phase. Follow the prompts below. v Color the phase in which most cell growth occurs BLUE v Color the phase in which DNA replication occurs RED. v Color the phase in which preparation for mitosis G2 occurs in YELLOW. v Color the phase in which mitosis and cytokinesis occur in GREEN. 4. Which three phases make upinterphase? GI M 5. Which of the following best describes cancer? Circle the correct answer. uncontrolled cell growth cells stop growing 6. If a dog has 72 chromosomes in a SOMATIC cell, how many chromosomes will its daughter cells have after meiosis_? mitosis_? P.arrow_forward
- "Agent V" is the name of an anticancer (chemotherapy) drug. This drug works against cancer cells by inhibiting the formation of microtubules in sensitive cells. Consider a cell that is sensitive to agent V (in other words, agent V is effective at stopping growth of this cell). Based on this information, agent V would cause the cell to be frozen at which of the major cell cycle checkpoints (G1, G2 or M checkpoint)? Explainarrow_forwardIn cell cycle, under the control system, explain in details (including roles of related proteins): a) How mitogens trigger transcription of genes for entry into S phase. b) During M phase, how M-Cdk can trigger cohesin dissociation as well as Mad2 triggers mitotic checkpoint to delay metaphase to anaphase transition.arrow_forward"Agent V" is the name of an anticancer (chemotherapy) drug. This drug works against cancer cells by inhibiting the formation of microtubules in sensitive cells. Consider a cell that is sensitive to agent V (in other words, agent V is effective at stopping growth of this cell). Based on this information, agent V would cause the cell to be frozen at which of the major cell cycle checkpoints (G1, G2 or M checkpoint)? Explain your answer in 2- 4 sentences.arrow_forward
- What celluar events/processes are associated with G1,S,G2,and M phases of the cell cycle? With the phases of mitosis? Some example: A. DNA replication B. Beginning of mitosis C. Normal cell growth and function D. Breaksdown of nuclear membrane E.Separation of sister chromatids F.Alignment of chromosomes on the equator of the cell H.Triggering the compaction and condensation of chromosomes I. Attachment of microtubles to kinetochoresarrow_forwardof my celle chose are wels smaller than normal. According to Model 1, what part(e) of the cell cycle is (ere) ou likely being affected? Some cancerus me 7. In Model 1, if the length of the arrow represents time, then for those cancerous cells, what hap pens to the time that is necessary for the cell cycle? What implication might this have for doctors who are treating cancer patients? Why? Living things must grow and develop. At times they suffer injuries or damage, or cells simply wear out. New cells must be formed for the organism to survive. What process must occur to make a new, properly- functioning cell? Model 1 - Mitosis as Part of the Cell Cycle Prophase Metaphase Anaphase Mitosis How do living things grow and repair themselves! Replicated chromosome (2 sister chromatids) 0000 * Centriole Spindle fibers Nuclear membrane Telophase 1. Refer to Model 1. List the four phases in the mitosis process. 2. Where is mitosis in the cell cycle? Before 3. What three phases of the cell cycle…arrow_forwardWhen considering the stages of the cell cycle, which stage is best associated with cells that do not divide, such as nerve cells? G1 phase M phase O None - all cells divide S phase G2 phase GO phase Pickles are often preserved in a 20-30% salt solution called brine. How does brine prevent contamination by microorganisms? Bacteria can't survive in hypotonic solutions because of the added pressure of the water they take in causing them to burst. O Bacteria can't survive in a hypertonic solution because they lose too much water and die. O The high salt concentration increases the pH of the environment, making it unfavorable for bacteria to live there. The high salt concentration creates an isotonic environment that the bacteria cannot live in. Bacteria cells are unable to digest the salt, thus killing the cells by starvation.arrow_forward
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