Biology: Life on Earth
10th Edition
ISBN: 9780321729712
Author: Gerald Audesirk, Teresa Audesirk, Bruce E. Byers
Publisher: Benjamin Cummings
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Chapter 21, Problem 2AC
Prior to the development of synthetic drugs, more than 80% of all medicines were of plant origin. Even today, indigenous tribes in remote Amazonian rain forests can provide a plant product to treat virtually any ailment. Herbal medicine is also widely and successfully practiced in China. Most of these drugs are unknown to the Western world. But the forests from which much of this plant material is obtained are being converted to agriculture. We are in danger of losing many of these potential drugs before they can be evaluated by Western medicine. What steps can you suggest to preserve these natural
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A crude extract sample was obtained from a plant and was found effective as an anti-diabetic agent in-vitro. The researcher wants to determine the appropriate lethal dose of the sample because it was intended to be administered orally. Literature studies show that plants under the same genus with the source of the crude extract has a lethal dose of 300 mg/Kg BW. Your group performed the test following the OECD Guideline 423 and used the recommended starting dose. The derived approximate LD50 was 25 mg/Kg BW.
1.With the approximate LD50 of the plant sample tested in the case, determine and interpret the TI of the sample if the ED50 is:
A. 40 mg/Kg BW
B. 18 mg/Kg BW
C. 3 mg/Kg Bw
A crude extract sample was obtained from a plant and was found effective as an anti-diabetic agent in-vitro. The researcher wants to determine the appropriate lethal dose of the sample because it was intended to be administered orally. Literature studies show that plants under the same genus with the source of the crude extract has a lethal dose of 300 mg/Kg BW. Your group performed the test following the OECD Guideline 423 and used the recommended starting dose. The derived approximate LD50 was 25 mg/Kg BW.
Why would a drug with a TI of less than 1 be considered as the primary treatment of a certain disease?
Chapter 21 Solutions
Biology: Life on Earth
Ch. 21 - 1. Scientists hypothesize that the ancestors of...Ch. 21 - Plant adaptations to life on land include a(n)...Ch. 21 - 3. Seedless vascular plants must reproduce when...Ch. 21 - 4. Three groups of nonvascular plants are _______,...Ch. 21 - 1. What is meant by “alternation of generations”?...Ch. 21 - 2. Explain the evolutionary changes in plant...Ch. 21 - Describe evolutionary trends in the life cycles of...Ch. 21 - Prob. 4RQCh. 21 - List the structural adaptations necessary for the...Ch. 21 - The number of species of flowering plants is...
Ch. 21 - List the adaptations of gymnosperms that have...Ch. 21 - What is a pollen grain? What role has it played in...Ch. 21 - The majority of all plants are seed plants. What...Ch. 21 - You are a geneticist working for a firm that...Ch. 21 - 1. Prior to the development of synthetic drugs,...Ch. 21 - 2. Only a few hundred of the more than 200,000...
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