Microbiology: An Introduction
11th Edition
ISBN: 9780321733603
Author: Gerard J. Tortora, Berdell R. Funke, Christine L. Case
Publisher: Benjamin Cummings
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Textbook Question
Chapter 20, Problem 6R
Why does a cell die from the following antimicrobial actions?
- a. Colistimethate binds to phospholipids.
- b. Kanamycin binds to 70S ribosomes.
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What kind of drug might be made out of an antimicrobial peptide and describe an advantage it would have over a drug like penicillin?
Whether an antimicrobial is broad spectrum or narrow spectrum depends on its
mode of action. For the following 2 hypothetical drugs, predict whether they are
broad spectrum or narrow spectrum. Explain your reasoning:
4.
a. Drug A interferes with peptidoglycan synthesis -
b. Drug B interferes with 70S ribosome function-
c. Drug C interferes with synthesis of a vitamin –
Match the following drug targets with the type of antibiotic that uses them (answers may be used more than once or not at all).
a. Cell wall
b.Cell membrane
c. Protein synthesis (Transcription/Translation)
d. Metabolic Pathway
e. Nucleic Acid synthesis
Chloramphenicol
Clindamycin
Erythromycin
Doxycycline
Sulfonamides
Answer these multiple-choice questions as well. Please give just the answer and no explanation.
1. Which is not true of virus capsids?a. They surround and protect viral nucleic acidb. Always icosahedral in shapec. Remain outside of host bacterial cells while the nucleic acid is injected into the bacterial
celld. Enters host animal cells together with the nucleic acid
e. Made up of protein subunits called capsomeres
2. All viruses have:
a. DNA
b. RNAc. Envelopesd. Glycoprotein spikes
e. Host specificity
3. Use the following to select the sequence of events during replication of DNA viruses in animal
cells:1 = replication of viral nucleic acid2 = adsorption3…
Chapter 20 Solutions
Microbiology: An Introduction
Ch. 20 - DRAW IT Show where the following antibiotics work:...Ch. 20 - List and explain five criteria used to identify an...Ch. 20 - What similar problems are encountered with...Ch. 20 - Define drug resistance. How is it produced? What...Ch. 20 - List the advantages of using two chemotherapeutic...Ch. 20 - Why does a cell die from the following...Ch. 20 - How does each of the following inhibit...Ch. 20 - The OH is missing from carbon 39 in ddI. How does...Ch. 20 - Compare the method of action of the following...Ch. 20 - NAME IT This microorganism is not susceptible to...
Ch. 20 - Which of the following pairs is mismatched? a....Ch. 20 - Prob. 2MCQCh. 20 - Prob. 3MCQCh. 20 - An antimicrobial agent should meet all of the...Ch. 20 - The most selective antimicrobial activity would be...Ch. 20 - Prob. 6MCQCh. 20 - Which of the following will not affect eukaryotic...Ch. 20 - Cell membrane damage causes death because a. the...Ch. 20 - A drug that intercalates into DNA has the...Ch. 20 - Chloramphenicol binds to the 50S portion of a...Ch. 20 - Prob. 1ACh. 20 - Why is idoxuridine effective if host cells also...Ch. 20 - Some bacteria become resistant to tetracycline...Ch. 20 - The following data were obtained from a...Ch. 20 - Prob. 5ACh. 20 - The following results were obtained from a broth...Ch. 20 - Vancomycin-resistant Enterococcus faecalis was...Ch. 20 - Prob. 2CAECh. 20 - Prob. 3CAE
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- A doctor prescribes a new antimicrobial drug to treat a patient's bacterial meningitis A student asks whether penicillin would kill the pathogen in question The physician answers: "Maybe , but...". What is the best way to complete this sentence. Explainarrow_forwardWhich of the following compounds represents a peptidoglycan specific antibiotic ? A. tetracycline B. chloramphenicol C. penicillin D. aspirinarrow_forwardWhich of the following drugs inhibits protein synthesis through binding to ribosomal 30S subunit: O a. Linezolid O b. Amikacin O c. Ciprofloxacin O d. Azithromycinarrow_forward
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- It was important for Lilly to understand how the bacteria were able to cause disease in patients. The mechanism of pathogenesis by M. tuberculosis starts in the lung alveoli. The cell wall of M. tuberculosis allows it to resist phagocytolysis by the alveolar macrophages, where they can multiply. They can then induce apoptosis in macrophages, which die, and the bacteria is free to infect other macrophages. As the cycle of infection slowly progresses, the body's response to the infection is to try to wall off the bacteria in granulomas (wall of immune cells, both dead and alive, surrounding the bacteria to restrict its spread). Eventually, the bacteria can escape the granuloma and infect other parts of the lung. Transmission of Mtb Initial infection and Granuloma cavitation replication of Mtb in macrophages and dissemination of Mtb in the lung Infected macrophages Caseating granuloma Recruitment of Innate and adaptive immune cells Infected cells undergo necrosis resulting in the…arrow_forwardIt was important for Lilly to understand how the bacteria were able to cause disease in patients. The mechanism of pathogenesis by M. tuberculosis starts in the lung alveoli. The cell wall of M. tuberculosis allows it to resist phagocytolysis by the alveolar macrophages, where they can multiply. They can then induce apoptosis in macrophages, which die, and the bacteria is free to infect other macrophages. As the cycle of infection slowly progresses, the body's response to the infection is to try to wall off the bacteria in granulomas (wall of immune cells, both dead and alive, surrounding the bacteria to restrict its spread). Eventually, the bacteria can escape the granuloma and infect other parts of the lung. Transmission of Mtb Initial infection and Granuloma cavitationy replication of Mtb in macrophages and dissemination of Mtb in the lung Infected macrophages Caseating granuloma Recruitment of Innate and adaptive immune cells Infected cells undergo necrosis resulting in the…arrow_forwardWhat is the mechanism of action of the antimicrobial used to treat patients with Fungal infections * a. Inhibits ergosterol synthesis b. Inhibits glucan synthesis c. Inhibits protein synthesis d. Inhibits nucleic acid synthesisarrow_forward
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