Concept explainers
Interpretation:
Concept introduction:
Many amino acids are linked together through amide bonds to form a biologically large molecule known to be proteins.
Amino
Secondary structure of protein is the repeating structural patterns (
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Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
- Using a copy of a helical wheel (attached to the end) plot the amino acids of the helix on the helical wheel. Is there any evidence of the helix as a whole being amphipathic or having a “sidedness"? Explain yes or no. Are the amino acid side chains in close proximity of one another or staggered to minimize steric hinderance between side chains? Explain the pattern you observe.arrow_forwardDraw the structural formula of the oligopeptide if the amino acids are arginine, glutamine, glycine, methionine and glutamic acid considering the first amino acid is the N-terminusarrow_forwardDraw out the structural formula of the oligopeptide, with the first amino acid as the N-terminusarrow_forward
- Give the effect of the following changes in the protein structure of hemoglobin Replacement of analanine located at the middle of helix B with prolinearrow_forwardThe structure of an alpha helix orients the oxygens of the carbonyl group of the peptide bond towards the C-terminal end of the helix while the hydrogens of the NH groups orient toward the N-terminal end, thus imparting a dipole along the length of the helix. As a result, which kinds of amino acids would favor the C-terminal end, and which would favor the N-terminal end? negatively charged, positively charged positively charged, negatively charged negatively charged, hydrophobic positively charged, hydrophobic hydrophobic, negatively charged hydrophobic, positively chargedarrow_forwardIn an alpha helix, the carbonyl oxygen of residue n is hydrogen bonded to the amide proton of residue n+x, where x is equal to 2 3 4arrow_forward
- Draw the strucures of Adenosine Triphosphate (ATP) and Cytidine Triphosphate and Show how they combine to form the polynuleotide (i.e. only the end product). Show at any one of these structures where the glycosidic bond occursarrow_forwardHelices can be described by the notation nm,where n is the number of residues per helical turn and m is the number of atoms, including H, in the ring that is closed by the hydrogen bond. Would a 310 helix be more or less steep than an α helix? why?arrow_forwardIt is often the case that a helices are positioned in a protein such that one side faces the interior of the protein and the other, the surface of the protein. These are said to be amphiphilic helices because they face different environments. Using a helical wheel projection (shown below), which of the peptide(s) below might form an amphiphilic helix? 8 15 1 12 4 11 16 18 9 7 14 13 10 17 O SLIKSVIEMVDEWFRTFL O FLIRVLRKVFRVLTRILS O RLFRSRVLKIAVIRFLLIarrow_forward
- Draw the RNA dinucleotide formed if deoxyguanidine 5'phosphate and deoxythymidine 5'phosphate monophosphates undergo a condensation reaction. Label the 5' and 3' ends of your structure. 0-P-O-CH2 NH2 --P-O-CH2 Identify the phosphodiester bond. \H KH H. H H H H ОН H ОН H Garrow_forwardIn the following polypeptide, which amino acid would be participating in hydrogen bonding with alanine, given this sequence forms an alpha helix? Please write out the full amino acid name, not the abbreviation. Met-Ala-Leu-Glu-Lys-Thr-Leu-Valarrow_forwardAn π helix can be described as a 4.4, helix. Explain 16 what this designation means. Given the pitch of the helix is 5.2 angstroms, how long in(nm) is the pi helix that has six residues.arrow_forward
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