Concept explainers
To review:
The possibility of trunk neural crest cells which are multipotent stem cells, to act as novel developmental seeds, which later retained as adult stem cells in each of their final destinations.
Introduction:
The emergence of neural crest is one of the important event in animal evolution. This is a transient structure which is derived from the ectoderm and sometimes considered as a fourth germ layer. The neural crest is defined as a population of cells which have a tendency to produce diverse tissues. This is divided into four types: Cranial or cephalic neural crest, Cardiac neural crest, Trunk neural crest, and the fourth one is vagal and sacral neural crest.
Explanation of Solution
Neural crest cells are characterized as multipotent cell population, with the capability of migration. These migratory cells have a tendency to generates diverse array of cell types during the process of vertebral development. The trunk neural crest possses a particular significance because of their diverse roles like morphogenetic role in the development of peripheral nervous system, secretory cells in endocrine system, pigment cells etc.
The hypothesis based on the multipotent nature of trunk crest cells indicate that adult stem cells bears plasticity. Adult stem cells shows the transdifferentiation and dedifferentiation which explain the plasticity properties. Neural crest cells have pluripotency and it has been proposed that pluripotent neural crest cells have a tendency to modify during the migration to their final destination.
Thus it is concluded that trunk neural crest cells may act as developmental seeds and because of their pluripotent nature they can retain as adult stem cells in each of their final destinations.
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Chapter 15 Solutions
Developmental Biology
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