Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 1, Problem 35P
Interpretation Introduction
Interpretation:
The average lifetime risk of the disease for the 95 % of the population should be calculated.
Concept introduction:
The genetic disorders are the hereditary diseases that are passed on to the off springs by the parent’s gene. Some genetic disorders are caused due to the mutations in the DNA strands. Such defects are inherited only if they appear to be in germline. Examples of genetic disorders are Tay-Sachs disease, Huntington’s disease, and Sickle cell anemia.
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Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the hemoglobin molecule.
Hemoglobin carries oxygen in your red bloods cells. The mutation causes these red blood cells to become stiff &
sickle-shaped when they release their oxygen. The sickled cells tend to get stuck in blood vessels, causing pain and
et: Deletio..
increased risk of stroke, blindness, damage to the heart & lungs, and other conditions.
DNA CA ..
Analyze the DNA strands below to determine what amino acid is changed AND what type of mutation occurred
bin DNA C.
CACGTAG
ACT AGGACTC..
Normal hemoglobin DNA
Normal hemoglobin MRNA:
Normal hemoglobin Amino Acid sequence:
Sickle cell hemoglobin DNA
CACGTAGACTGAGGACAC..
Sickle cell hemoglobin MRNA:
Chapter 1 Solutions
Biochemistry
Ch. 1 - Prob. 1PCh. 1 - Prob. 2PCh. 1 - Prob. 3PCh. 1 - Prob. 4PCh. 1 - Prob. 5PCh. 1 - Prob. 6PCh. 1 - Prob. 7PCh. 1 - Prob. 8PCh. 1 - Prob. 9PCh. 1 - Prob. 10P
Ch. 1 - Prob. 11PCh. 1 - Prob. 12PCh. 1 - Prob. 13PCh. 1 - Prob. 14PCh. 1 - Prob. 15PCh. 1 - Prob. 16PCh. 1 - Prob. 17PCh. 1 - Prob. 18PCh. 1 - Prob. 19PCh. 1 - Prob. 20PCh. 1 - Prob. 21PCh. 1 - Prob. 22PCh. 1 - Prob. 23PCh. 1 - Prob. 24PCh. 1 - Prob. 25PCh. 1 - Prob. 26PCh. 1 - Prob. 27PCh. 1 - Prob. 28PCh. 1 - Prob. 29PCh. 1 - Prob. 30PCh. 1 - Prob. 31PCh. 1 - Prob. 32PCh. 1 - Prob. 33PCh. 1 - Prob. 34PCh. 1 - Prob. 35PCh. 1 - Prob. 36P
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