Which synthetic sequence will give the following overall transformation? how? (1) LDA / THF; (2) CH31; (3) H2 / Pd on C a. H2 / Pd on C b. (1) HBr; (2) CH3LI; (3) H2 / Pd on C C. (1) BH3 / THF; (2) H2O2: (3) CH3LI d. (1) Li / NH3(iq): (2) CH3I Oe.
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- What is an appropriate stepwise synthesis for the conversion shown? a-do O PBr3; PCC; H₂O O PBr3; H₂SO4; PCC; H₂O O KMnO4; CrO3; H₂O O KMnO4/NaOH/H₂O (hot); H₂O O KMnO4/NaOH/H₂O (cold); CrO3/H₂SO4/H₂O -OH OWhich synthetic route(s) would complete the reaction shown? Br || ||| I and II O I and III ? HO OH + enantiomer Synthesis I: 1. NaCCCH3; 2. Na/NH3(I) ;3. OsO4; 4. NaHSO3, H₂O Synthesis II: 2. NaCCCH3; 2. H2, Lindlar's catalyst; 3. MCPBA; 4. aq. H₂SO4 Synthesis III: 1. NaCCCH3; 2. H₂, Pt; 3. MCPBA; 4. aq. H₂SO46) Give the structures of the compounds A-E in the synthetic sequences below. PBr3, Br2 NH3, excess LOH A B you 1) NaNH2 (1 equiv) H2O, HgSO4 Br2 excess HCECH C D E H2SO4 NaOH excess 2) BuCI (1 equiv)
- What reagents are necessary to carry out the conversion shown? OH CH₂CH3 CH₂CH3 O Na₂Cr₂O7/H2SO4/H₂O; CH3CH₂CH₂CH₂MgBr; H₂O O Na2Cr₂O7/H2SO4/H2O; SOCI2; excess CH3CH₂CH₂CuLi; H₂O O Na₂Cr₂O7/H₂SO4; excess CH3CH₂MgBr; H3O+ O Na₂Cr₂O7/H₂SO4/H₂O; SOCI₂; excess CH3CH₂MgBr; H₂O O Na₂Cr₂O7; SOCI2; CH3CH₂MgBr; H₂OIdentify the reagents necessary for all three methods. ? OH ajay O CH3CH₂ONa ? ? 1) NaOH; 2) CH3CH₂OH CH3CH₂OH, H₂SO4 1) NaOH; 2) CH3CH₂Br OCH3CH₂Br, H₂SO4 □1) SOCI₂; 2) CH3CH₂OH, pyridine OEtProvide the reagents necessary to carry out the conversion shown. 1. H2O; 2. KMnO4 1. O3; 2. DMS; 3. Na2Cr2O7/H2SO4/H2O 1. NaOH, Br2; 2. DMS; 3. H2O/heat 1. O3; 2. DMS; 3. KMnO4 1. DMS; 2. H2O2/heat
- Show a possible mechanism for the following reaction 1) EtMgBr (еxcess) 2) H20 Et OH Me •Me "Et w..Which reagents can be used to achieve synthesis of the indicated target molecule? Conc. KMNO4/ H* / acetone 1) O3/ Zn/H* 2) PCC/CH2Cl2 O 1) Conc. KMNO4 /H* 2) LIAIH4/THF 4) H3O* 1) Conc. KMNO4, 2) HBr, 3) Mg/ether, 4) CO2 O3/ Zn/H*This is a multi-step synthesis problem. What reagents are need to carry out the shown chemical transformation ? OH 1.) SOCI2; 2.) D20 3.) NaBD4 O1. 1.) PBr3; 2.) LDA; 3.) BD3 and D202 2. 1.) PBr3; 2.) CuBr; 3.) D20 3. 1.) Tos-Cl; 2.) LiBr; 3.) D20 O4. 1.) SOCI2; 2.) Mg; 3.) D20 5.
- 34. Select the best synthetic sequence to accomplish the transformation shown. Br A. 1. NaOEt; 2. HBr, cold, dark; 3. H₂SO4, H₂O B. 1. NaOEt; 2. HBr hv, A; 3. KO/Bu C. 1. NaOEt; 2. HBr cold, dark; 3. KOtBu D. 1. NaOEt; 2. Br₂; 3. KOBU E. 1. NaOEt; 2. Br₂, hv 35. In the retrosynthesis shown below: which compound could be converted to the alkyne shown in a single reaction step, with the appropriate reagents? Br -Bri Br Br || ||| IV B. C. D. E. None 36. In the retrosynthesis shown below: which compound(s) could lead to the alcohol shown in a single step, with the appropriate reagents? OH IV I B. 11 C. ||| D. E. A. I & II 37. Which alkene cannot be converted into an alkyne by reacting it with 1) bromine followed by 2) an excess of sodium amide and then 3) water? || IV B. C. E. All work D. BrChoose the correct reagents and reaction sequence for the following transformation. ? CH3 Br CH3 -СООН O A. (1) HCN; (2) KOH/H2O, D; (3) H*/H2O O B. (1) Mg/ether; (2) acetone; (3) CrO3/H2SO4, D O C. (1) NaCN, D; (2) NaOH/H2O, D; (3) H*/H2O O D.(1) Mg/ether; (2) CO2; (3) H*/H20Provide the reagents necessary to carry out the following conversion using a Stork enamine synthesis. O LO -O; H3O+ CH3NH/H₂SO4; NaOCH 3; (CH3)2NH/H2SO4; (CH3)2NH/H2SO4; CH3NH/H₂SO4; =O; H3O+ =O; H3O+ -O; H3O+ FO; H3O+