Which of the following statements is/are TRUE? Multiple answers: Multiple answers are accepted for this question Select one or more answers and submit. For keyboard navigation... SHOW MORE The CAMP formed by adenyl cyclase does not persist because 5'-Phosphodiesterase activity prevalent in cells hydrolyzes CAMP to give 5'-AMP. Caffeine inhibits 5'-phosphodiesterase activity which promotes the presence of the more active 'a' form of Glycogen Phosphorylase. a If no precautions are taken blood that has been stored for some time becomes depleted in 2-3 BPG which will result in

Organic Chemistry
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Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
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Chapter18: Functional Derivatives Of Carboxylic Acids
Section18.8: Interconversion Of Functional Derivatives
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Which of the following statements is/are TRUE?

Which of the following statements is/are TRUE?
Multiple answers: Multiple answers are accepted for this question
Select one or more answers and submit. For keyboard navigation... SHOW MORE v
The CAMP formed by adenyl cyclase does not persist because 5'-Phosphodiesterase activity prevalent in cells hydrolyzes
CAMP to give 5'-AMP. Caffeine inhibits 5'-phosphodiesterase activity which promotes the presence of the more active 'a'
form of Glycogen Phosphorylase.
a
If no precautions are taken blood that has been stored for some time becomes depleted in 2-3 BPG which will result in
increased binding of 0, to Hemoglobin with decreased release of 02 to tissues.
Sickle-cell anemia is the consequence of HbS polymerization through hydrophobic contacts between the side chain Vala6
and a pocket in the EF corner of a-subunits.
d
Decreasing the free energy of activation decreases the reaction rate.
e
The catalytic efficiency of an enzyme cannot exceed the diffusion rate of encounters between E and S.
f
When [S] = Km the velocity = Vmax/2.
Lineweaver-Burk double reciprocal (1/V vs. 1/S) plots convert the hyperbolic Michaelis-Menten V vs. S plot into a straight
line.
According to the Michaelis-Menten equation the v/Vmax ratio = 0.4 when [S] = 4 Km.
i
If V,
= 100 umol/mL/sec and Km = 2 mM the velocity of the reaction when [S] = 20 mM is 10 µmol/mL/sec.
max
Transcribed Image Text:Which of the following statements is/are TRUE? Multiple answers: Multiple answers are accepted for this question Select one or more answers and submit. For keyboard navigation... SHOW MORE v The CAMP formed by adenyl cyclase does not persist because 5'-Phosphodiesterase activity prevalent in cells hydrolyzes CAMP to give 5'-AMP. Caffeine inhibits 5'-phosphodiesterase activity which promotes the presence of the more active 'a' form of Glycogen Phosphorylase. a If no precautions are taken blood that has been stored for some time becomes depleted in 2-3 BPG which will result in increased binding of 0, to Hemoglobin with decreased release of 02 to tissues. Sickle-cell anemia is the consequence of HbS polymerization through hydrophobic contacts between the side chain Vala6 and a pocket in the EF corner of a-subunits. d Decreasing the free energy of activation decreases the reaction rate. e The catalytic efficiency of an enzyme cannot exceed the diffusion rate of encounters between E and S. f When [S] = Km the velocity = Vmax/2. Lineweaver-Burk double reciprocal (1/V vs. 1/S) plots convert the hyperbolic Michaelis-Menten V vs. S plot into a straight line. According to the Michaelis-Menten equation the v/Vmax ratio = 0.4 when [S] = 4 Km. i If V, = 100 umol/mL/sec and Km = 2 mM the velocity of the reaction when [S] = 20 mM is 10 µmol/mL/sec. max
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