The following are drugs that act as anti-tumor agents and are often used as part of chemotherapeutic regimens for cancer patients. Explain how the use of the following drugs may prevent cancer cell growth and/or proliferation.
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The following are drugs that act as anti-tumor agents and are often used as part of
chemotherapeutic regimens for cancer patients. Explain how the use of the following drugs may
prevent cancer cell growth and/or proliferation.
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- The pireaple Ssynaling prthony is asa commbly dsagphad in some fiype of Cancers o growth factor Pineappte reltptor Coconut time for Lell. Divsion "OFE Juity ON" When it is time for the cell to Mivilde, other ello in the backy helkare gouth factor molecdes, These bind to the pineapple receptoss in And the cell menmbane a One ths mppens, the toP protein becomes aitire. TOP In turn activates iy protein Which drives cell cyde forwarel. Howere, Hs mportant that the cell not divide centinuadly. Coconut protcin makes Sure Suiy tuns off once the cell completes divisiona Questions ) Top prokin is a und a mutation could enuse Lancer. 2) Juiy proein i5 a und a mutution coreld cause Lancer : 3 Cocoaut protkcin is a aod a mitution ceeled lnse canor word bank LOF, GOF, tunur Proto -oncoprotoin suppressor,Define E-cadherin activity is lostduring the epithelial-to-mesenchymal transition and during cancerprogression.One important role of Fas and Fas ligand is to medi-ate the elimination of tumor cells by killer lymphocytes.In a study of 35 primary lung and colon tumors, half thetumors were found to have amplified and overexpressed agene for a secreted protein that binds to Fas ligand. How doyou suppose that overexpression of this protein might con-tribute to the survival of these tumor cells? Explain yourreasoning.
- Our government has finite funds to devote to cancer research.Discuss which of the following areas of research you think shouldreceive the most funding.A. Identifying and characterizing oncogenes and tumorsuppressorgenesB. Identifying agents in our environment that cause cancerC. Identifying viruses that cause cancer D. Devising methods aimed at killing cancer cells in the bodyE. Informing the public of the risks involved in exposure tocarcinogensIn the long run, in which of these areas would you expect successfulresearch to be the most effective in decreasing human mortalitydue to cancer?Explain the mechanism of these in cancer treatment, all details needed. no details no rate.Proto-oncogenes can be converted to oncogenes in a numberof different ways. In some cases, the proto-oncogene itselfbecomes amplified up to hundreds of times in a cancer cell.An example is the cyclin D1 gene, which is amplified in somecancers. In other cases, the proto-oncogene may be mutatedin a limited number of specific ways, leading to alterations inthe gene product’s structure. The ras gene is an example of aproto-oncogene that becomes oncogenic after suffering pointmutations in specific regions of the gene. Explain why thesetwo proto-oncogenes (cyclin D1 and ras) undergo such differentalterations to convert them into oncogenes
- At any given time, intestinal crypts of mice com-prise about 15 stem cells and 10 Paneth cells. After celldivision, which occurs about once a day, the daughtercells remain stem cells only if they maintain contact with aPaneth cell. This constant competition for Paneth-cell con-tact raises the possibility that crypts might become mono-clonal over time; that is, the crypt cells at one point in timemight derive from only 1 of the 15 stem cells that existedat some earlier time. To test this possibility, you use theso-called confetti marker that upon activation expressesany one of three fluorescent proteins in the stem cells ofthe crypt. You then examine crypts at various times todetermine whether they contain cells with multiple colorsor only one color (Figure Q22–1). Do the crypts becomemonoclonal over time or not? How can you tell?Discuss why cancer treatment may involve a combinationof chemotherapy, radiation therapy, and surgery.Need detail explanation Scenario: A 56-year-old client was diagnosed with aggressive bone cancer that required a below the knee amputation of the left leg 14 months ago. The client received recommended chemotherapy and radiation, but it was found recently that the cancer has metastasized to the chest and skull. There is lymph node involvement with a primary tumor partially obstructing the right kidney. The client was readmitted 4 days ago for removal of the remaining portion of the left leg and was told that there is no appropriate surgical or medical intervention that would be beneficial at this point in the disease process. The interdisciplinary health care team has recommended palliative care upon discharge since the client’s life expectancy is between 3 and 5 months. The client has developed a mutually respectful relationship with a nurse on the unit who has provided care throughout all previous hospitalizations. The client shares with the licensed practical nurse (LPN) that, “I…
- Describe the logistics of how these electrochemical sensors are used in cancer detection/ diagnosis for tumorous cancersThe growth fraction of the cancer types A 8, C, and D are 23%, 45%, 56%, and 78%, respectively. Which type of cancer is more suceptible to the chemotherapy?Primary efecd al Increase the offmity of R NA pelymerase buding to a promrter, b) facilitate recombiraton doning ) Rovide prostectio.. agamst mtogratrien of lysogamic dl Generate of transposens? me iesis, ViYUses - mututions and chromosomal rearrargenments. el Conduct ONA reglication proofreadng àl Antibotics to freat infectons caused by facu Hontive bactenia athactve anaerabic homans, the teryets which would in be most shibiters of bacteriai are a) electon transgort. bl MRNA splicng ) hansciphion dl poly -A addion for MRNAS- e Nine of the abouer ) Which is a cheractenstic of eu Korgetic peten syntheni> polycistremic acid tans lated is formyl-methionme. a) {ukuryotic mRNA is bl The frst amino c) 'The MRNA most be polyadenglated atthe 3l end before trenslahion dl Er Karystia transcnphion e) Tansemphion and tenslation reguires single RNA polymenm Bccure duay as t t ig) If the alkle cousing sickle cell i> present at a amemia fres wancy of o.05 certain lorge, rendomly-mating in…