Two pure-breeding strains of mice are crossed to produce F1 mice that are heterozygous for three linked genes with alleles Aa, Bb, and Dd. Numerous triply heterozygous F1 mice are testcrossed, and the genotypes and numbers of the resulting progeny are as follows: A A- A- A- aa aa aa Total B- D- B- dd bb D- bb dd B- D- B- dd bb D- 10 350 100 40 60 120 320 1000 1.Which gene is in the middle? 2.Specify the genotype of the F1 triple heterozygote as completely as possible, with the genes in the correct order and the correct alleles on each chromosome. 3. Which two genes are closest together? 4.What is the map distance between the two closest genes? Assume that interference is complete between these two genes. 5.If interference is not complete, how will the true map distance differ from the value you calculated in part (d)? Briefly explain why this is so.

Biology (MindTap Course List)
11th Edition
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Chapter11: The Basic Principles Of Heredity
Section: Chapter Questions
Problem 11TYU: Individuals of genotype AaBb were mated to individuals of genotype aabb. One thousand offspring were...
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Two pure-breeding strains of mice are crossed to produce F1 mice that
are heterozygous for three linked genes with alleles Aa, Bb, and Dd.
Numerous triply heterozygous F1 mice are testcrossed, and the
genotypes and numbers of the resulting progeny are as follows:
A-
A-
A-
aa
aa
aa
Total
B
B-
bb
bb
B-
B-
bb
dd
dd
dd
10
350
100
40
60
120
320
1000
1.Which gene is in the middle?
2.Specify the genotype of the F1 triple heterozygote as completely as
possible, with the genes in the correct order and the correct alleles on
each chromosome.
3. Which two genes are closest together?
4.What is the map distance between the two closest genes? Assume that
interference is complete between these two genes.
5.If interference is not complete, how will the true map distance differ
from the value you calculated in part (d)? Briefly explain why this is so.
Transcribed Image Text:Two pure-breeding strains of mice are crossed to produce F1 mice that are heterozygous for three linked genes with alleles Aa, Bb, and Dd. Numerous triply heterozygous F1 mice are testcrossed, and the genotypes and numbers of the resulting progeny are as follows: A- A- A- aa aa aa Total B B- bb bb B- B- bb dd dd dd 10 350 100 40 60 120 320 1000 1.Which gene is in the middle? 2.Specify the genotype of the F1 triple heterozygote as completely as possible, with the genes in the correct order and the correct alleles on each chromosome. 3. Which two genes are closest together? 4.What is the map distance between the two closest genes? Assume that interference is complete between these two genes. 5.If interference is not complete, how will the true map distance differ from the value you calculated in part (d)? Briefly explain why this is so.
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