stop codon. C Chr1 Bace2 180 180 Exon 1 Exon 2 Exon 3 Exon 5 Exon 7 Exon 9 Exon 4 Exon 6 Exon 8 200 269 ATGCTGATC 176 CTGGCGCTCGCCCTGGAGCCC GCC GGCGGCGCCGCC CTGGCGC CGCC ATGCTGATC L 25 bp deletion Premature stop codon This means that brown bears have: shorter mRNA than black bears no transcription of exons after Exon 1

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3a. The deletion found in Bace2 is in Exon 1, and codes for a premature
stop codon.
Chr1
Bace2
180 180
Exon 1
Exon 3
Exon 5
Exon 7
Exon 9
Exon 2
Exon 4
Exon 6
Exon 8
176
CTGGCGCTCGCCCTG
CTGGCGC
25 bp
deletion
This means that brown bears have:
200
GCGGC GCCGCC
269
ATGCTGATC
CGCC
ATGCTGATC
Premature
stop codon
shorter mRNA than black bears
no transcription of exons after Exon 1
fewer amino acids made during translation
no chromosome 1
3b.
If the deletion had been a 24 bp deletion, do you think that the
brown bear phenotype would exist? Why or why not (choose the
best answer)?
Yes this deletion is in an exon, it was always going to change
the phenotype
Yes this deletion is in the first exon, it was always going to
-
change the phenotype
No, 25 bp deletion led to a frameshift, 24 would not have
resulted in a frame shift
No, a 24 bp would have led to allelic haplosufficency
Transcribed Image Text:3a. The deletion found in Bace2 is in Exon 1, and codes for a premature stop codon. Chr1 Bace2 180 180 Exon 1 Exon 3 Exon 5 Exon 7 Exon 9 Exon 2 Exon 4 Exon 6 Exon 8 176 CTGGCGCTCGCCCTG CTGGCGC 25 bp deletion This means that brown bears have: 200 GCGGC GCCGCC 269 ATGCTGATC CGCC ATGCTGATC Premature stop codon shorter mRNA than black bears no transcription of exons after Exon 1 fewer amino acids made during translation no chromosome 1 3b. If the deletion had been a 24 bp deletion, do you think that the brown bear phenotype would exist? Why or why not (choose the best answer)? Yes this deletion is in an exon, it was always going to change the phenotype Yes this deletion is in the first exon, it was always going to - change the phenotype No, 25 bp deletion led to a frameshift, 24 would not have resulted in a frame shift No, a 24 bp would have led to allelic haplosufficency
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