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enamines act as nucleophiles
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- Enamines can serve as enolate surrogates in reactions at the a-carbon. In the reaction sequence, the structures of the enamine addition product – the initial iminium and its neutral tautomer – are shown. Draw the structures of the enamine and alkyl bromide reactants that would combine to form these intermediates, and draw the structure of the final product, obtained via hydrolysis of the neutral intermediate. iminium intermediate neutral intermediate tautomerization N. Reactants H20 hydrolysis product Draw the enamine and alkyl bromide reactants. Draw the hydrolysis product. ZIEnamines can serve as enolate surrogates in reactions at the a-carbon. In the reaction sequence, the structures of the enamine addition product – the initial zwitterion and its neutral tautomer – are shown. Draw the structures of the two reactants forming these intermediates, and draw the structure of the final product, obtained via hydrolysis of the neutral intermediate. initial zwitterionic intermediate neutral intermediate tautomerization Reactants H,0 hydrolysis product Draw the two reactants. Draw the hydrolysis product. Select Draw Rings More Erase Select Draw Rings More Erase H HExplain the below ? Carbanions are nucleophiles
- In an electrophilic aromatic substitution, the substitution pattern on the product is determine by the directing nature of the substituents on the ring. What controls the substitution pattern in a nucleophilic aromatic substitution reaction?Predict the nucleophilic substitution product.Identify the electrophile and the nucleophile in each of the following reaction steps and then draw curved arrows to illustrate the bond-making and bondbreaking processes.
- Define central relationship between nucleophilicity and basicity in comparing two nucleophiles?Explain why a methoxy group (CH3O) increases the rate of electrophilic aromatic substitution, but decreases the rate of nucleophilic aromatic substitution.Provide an explanation (in detail) on how base catalysts speed up nucleophilic reactions of carbonyl compounds.
- Enamines can serve as enolate surrogates in reactions at the a-carbon. In the following reaction sequence, the structures of the enamine addition product – the initial zwitterion and its neutral tautomer – are shown. Draw the structures of the two reactants forming these intermediates, and draw the structure of the final product, obtained via hydrolysis the neutral intermediate. reactants initial zwitterionic intermediate tautomerization hydrolysis product neutral intermediate NH н,о Н,о ↑In the following reactions; identify substrate, nucleophile and leaving groupRationalize the selectivity observed in the benzil reduction. Draw the transition states of the nucleophilic attack leading to either meso or racemic products and indicate why one is more stable than the other.