If the nucleophile in a condensation reaction is an enolate derived from an ester, what type(s) of condensation reaction(s) may occur? An aldol-type condensation reaction A Claisen-type condensation reaction

If the nucleophile in a condensation reaction is an enolate derived from an ester, what type(s) of condensation reaction(s) may occur? An aldol-type condensation reaction A Claisen-type condensation reaction

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter13: Substitution

Section: Chapter Questions

Problem 2CTQ

See similar textbooks

Related questions

Q: H;C CH3 -CH=CH-C -CH,CH3 -CH=Ċ- -CH3

Q: Draw the product formed (after dehydration) in the crossed aldol condensation of phenylacetaldehyde…

A: Cross aldol reaction is the reaction between two different aldehyde or ketone compounds. The product…

Q: (b) Why is the Claisen-Schmidt reaction a special type of aldol condensation? one of the…

A: Answers of the above questions given below.

Q: Which of the following statements about the rate of an Sn1 reaction of an alkyl halide is not true?…

A: An SN1 reaction is a substitution nucleophilic unimolecular reaction. This reaction occurs in more…

Q: For alkyl halide, the SN1 reaction loss of the leaving group occurs first to generate a carbocation…

A: SN1 reaction mechanism : Mechanism of SN1 reaction follow as - 1). This is a two step reaction. 2).…

Q: Which of the following nucleophiles will undergo conjugate addition in a Michael reaction? O lithium…

A: The Micheal reaction Or Micheal addition is a conjugate addition (1, 4-addition) of the carbanion to…

Q: Predict the products of aldol condensation, followed by dehydration, of the followingketones and…

A: (c) The products of aldol condensation, followed by dehydration of the cyclohexanone is shown below,

Q: 4. Give the structures of the aldol products that form when each of the following compounds or…

A: Hey, since there are subpart questions posted, we will answer three subparts. If you want any…

Q: Aldehydes that do not undergo aldol condensation are I) propanal II) trichloroethanal III)…

A: 1) With Grignard's reagent aldehydes gives organometallic compounds which on hydrolysis gives…

Q: Consider the mechanism for the aldol condensation shown below. Which of the following statements…

A: Applying concept of acid catalysed aldol reaction.

Q: Propose a mechanism, using curved arrows, for the base-catalysed aldol reaction and the subsequent…

Q: of LDA A LA achivator 6 Tidy Aldal- Tischenks Cl mol) (2 mol>

Q: The product below can be synthesized by a Robinson annulation, which is a Michael addition followed…

Q: What aldol product is formed when two molecules of butanal react together in the presence of base?…

A: Aldol condensation is an oragnic reaction involving the condensation of two carbonyl compounds into…

Q: The reagent is a Grignard reagent and is a source of CH3CH2- anions. Which epoxide carbon will the…

A: The epoxides are strained and undergoes nucleophilic addition reaction with Grignard Reagent.

Q: Give the IUPAC name of the reactants that would give the following aldol condensation product.

Q: intermediate product 13 2 7 5 NO2

A: Intermediate is " m-chloroethylbenzene "

Q: Predict the products of aldol condensation, followed by dehydration, of the followingketones and…

A: (a)

Q: In the following reaction, which chemical species is acting like a nucleophile? [ H,CO CH,O H;CO b)…

A: Nucleophile is the one which has the ability to donate a pair of electrons or possising negative…

Q: When a single compound contains both a nucleophile and a leaving group, an intramolecular reaction…

A: A nucleophilic substitution reaction is defined as the reaction in which a nucleophile attacks on…

Q: The reaction ofa ketone with an aldehyde in the preserice of a strong base is an example of a mixed…

A: In aldol condensation reaction atleast one alpha hydrogen present in carbonyl compound. In this…

Q: CH3 CH3-CECH CH3-C-CH3 CH3-0-CH3 EN: I II III IV

A: Electrophiles have low electron density while nucleophiles have high Electron Density.

Q: There are other condensation reactions similar to the aldol and Claisen condensations: a. The Perkin…

A: The Perkin condensation is the condensation of an aromatic aldehyde and acetic anhydride. It is…

Q: Which will form enolates? 1. Aldol condensation 2. Tranesterification 3. Dieckmann condensation 4.…

A: Condensation reaction are those in which water is eliminated when reactant react to form organic…

Q: There are other condensation reactions similar to the aldol and Claisen condensations:a. The Perkin…

A: Aromatic aldehydes when heated with the anhydride of an aliphatic acid(containing two alpha…

Q: Write the structures of the enone products you would obtain from aldol conden- sation of the…

A: Given compounds are : Write the structures of the enone products you would obtain from condensation…

Q: What is the major product for each of the following reactions? (If an enol is created, write both…

A: Here in this question, reagent gave are of nitration reaction. So nitration of given reactant para…

Q: If the enolate forms at carbon 1 and then reacts with the carbonyl carbon 5, what size ring product…

A: Organic compounds are mostly made up of carbon, hydrogen, oxygen and nitrogen atoms, and organic…

Q: What is the first step in the acid-catalyzed aldol condensation reaction. Attack of the…

A: Hi, we are supposed to answer one question. To get the remaining questions solved please mention the…

Q: Aldol reactions are synthetically useful reactions that can be combined with other reactions to…

Q: Draw the major organic product that forms in an intramolecular aldol condensation. Remember that…

A: Aldol condensationis the reaction in which aldehyde or ketone in the presence of a base. The given…

Q: What is the electrophile in an aldol addition reaction? An ester O An aldehyde or a ketone O An enol…

A: a) Aldol addition reaction- This reaction involves the combination of two carbonyl compounds to form…

Q: Which of the following species is likely to be a nucleophile and which an electrophile? (a) CH3CI…

A: This question belong to reaction mechanism organic chemistry. Electrophile : all positively charged…

Q: Predict the major products of the following base-catalyzed aldol condensations withdehydration.(a)…

Q: Give the structures of the aldol products that form when each of the following compounds or mixtures…

A: Aldol condensation is the reaction where an enolate reacts with a carbonyl compound to yield a…

Q: Which option best describes the arrow-pushing mechanism for the addition step in an aldol…

A: Answer :-…

Q: Which of the following molecules is not able to undergo an aldol self-condensation? CH₂ A H₂C 00.0 어…

A: we have to select the molecule which cannot participate in aldol self condensation

Q: What is the most likely product of the following reaction?

A: Benzene is treated with alkylhalides in presence of lewis acids like AlCl3 forms alkylated…

Q: In the alkylation of an enolate, which compound will most readily react? Br Br Br O H3C-Br CH3 Br

A: The answer is given as follows

Q: 1. Cl2, H20 2. NaOH Another mechanism for the formation of epoxides is through the formation of a…

Q: Which of the following terms best describes the reactive nature of a Grignard reagent? A)…

A: Grignard reagent is an organometallic (metal involved is magnesium) compound widely used in many…

Q: How each of the following could be synthesized by way of aldol condensation? a. n-butyl alcohol b.…

A: In Aldol condensation first base abstarct H+ then anion will attcak on carbonyl compound then Aldol…

Q: Predict the products of aldol condensation, followed by dehydration, of the followingketones and…

A: a) The first step in aldol condensation reaction is the formation of enolate ion by the abstraction…

Q: Which of the following is the most reactive to a nucleophile? O ethyl ethanoate O ethanoyl chloride…

A: The nucleophilicity of the considered compounds has been compared below.

Q: In an aldol condensation reaction, acetone and benzaldehyde are mixed in the presence of sodium…

A: Given: In an aldol condensation reaction, acetone and benzaldehyde are mixed in the presence of…

Q: MeO CO₂Et co.Et MeO 1 OMe 1. H3O+ 2. A MeO- MeO 2 OMe CO₂H MeO O MeO 3 OMe

Q: Predict the products of aldol condensation, followed by dehydration, of the followingketones and…

Q: Which of the following groups would NOT make a good nucleophile? A. amine B. carbonyl C. imidazole O…

A: Nucleophile is a substance which is electron rich in nature, it can be neutral (having lone pair of…

Q: The aldol double condensation reaction is highly selective for formation of a single double…

A: The involvement of carbonyl group takes place in the reactions of aldehydes and ketone, as the…

Q: What aldol product is formed when two molecules of butanal react together in the presence of base?…

A: What aldol product is formed when two molecules of butanal react together in the presence of base?…

Concept explainers

UV Visible Spectroscopy

Spectroscopy refers to the absorption or emission of light or other radiations by matter. When a substance or chemical absorbs light or radiation, they reach an excited state followed by de-excitation or emission of the light or radiation forming distinct spectra. UV-visible spectroscopy or ultraviolet-visible refers to the absorption and emission in the ultraviolet and visible regions of the electromagnetic spectrum.

Question

please help me with both parts of this question, I am very confused and am trying to study

If the nucleophile in a condensation reaction is an enolate derived from
an ester, what type(s) of condensation reaction(s) may occur?
An aldol-type condensation reaction
A Claisen-type condensation reaction

What is the approximate pka of the hydrogen adjacent to a nitrile
group?
O -15
-10
-20
O -25

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1 multiple

VIEW

Step 2

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

2 CH3COOCH,CH3 C2H5O'K*/C2H5OH ---> CH3COCH,COOCH,CH3 [+] Hofmann elimination Clemmensen reduction Claisen condensation O Cannizzaro reaction O Aldol condensation
2 H3C H3C H C→XT OH H3C The aldol reaction is a carbonyl condensation reaction between two carbonyl partners and involves a combination of nucleophilic addition and a-substitution steps. One partner is converted into an enolate ion nucleophile and adds to the electrophilic carbonyl group of the second partner. In the classic aldol reaction, the carbonyl partners are aldehydes or ketones, although aldehydes are more reactive. The product is a ß-hydroxy carbonyl compound. base :0: OH H H Under reaction conditions slightly more vigorous than those employed for the aldol reaction, the ß-hydroxyl group is eliminated in an E1cB dehydration to give an a,ß-unsaturated carbonyl compound. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instruct ns H3C heat OH H3C :0: H + H₂O H
Fill in the missing reagents a-e in the following scheme:
Explain how the Knoevenagel condensation is a variant of the aldol condensation.Draw reaction schemes to answer the question.
Elimination reactions require a nucleophile base
Acetal product formation requires an acid catalyst in the second step, but NOT in the first step. True or False?
This reaction is an example of conjugate addition of a nucleophile to an a,ß-unsaturated carbonyl. CНз CHз Нао ОН Draw the two resonance structures of the enolate anion intermediate for this reaction.
What is the strongest nucleophile, NH3, CH4, CH3O-, or H2O?
I H H3C NOC XT :0: MET H₂C base H3C The aldol reaction is a carbonyl condensation reaction between two carbonyl partners and involves a combination of nucleophilic addition and a-substitution steps. One partner is converted into an enolate ion nucleophile and adds to the electrophilic carbonyl group of the second partner. In the classic aldol reaction, the carbonyl partners are aldehydes or ketones, although aldehydes are more reactive. The product is a ß-hydroxy carbonyl compound. H OH q H3C H₂C H Under reaction conditions slightly more vigorous than those employed for the aldol reaction, the ß-hydroxyl group is eliminated in an E1cB dehydration to give an a,ß-unsaturated carbonyl compound. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions heat H H + H₂O
What aldol product is formed when two molecules of butanal react together in the presence of base? What reagents are needed to convert this product to each of the following compounds?
base 2 H3C H H3C OH heat H H3C + H₂O H The aldol reaction is a carbonyl condensation reaction between two carbonyl partners and involves a combination of nucleophilic addition and a-substitution steps. One partner is converted into an enolate ion nucleophile and adds to the electrophilic carbonyl group of the second partner. In the classic aldol reaction, the carbonyl partners are aldehydes or ketones, although aldehydes are more reactive. The product is a ẞ-hydroxy carbonyl compound. Under reaction conditions slightly more vigorous than those employed for the aldol reaction, the ẞ-hydroxyl group is eliminated in an E1CB dehydration to give an a,ẞ-unsaturated carbonyl compound. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions X :OH H₂O: а کی H₂C H H₂C H H
What is the product formed when each dicarbonyl compound undergoes an intramolecular aldol reaction, followed by dehydration.