Metabolizing a fatty acid via the B-oxidation pathway will generate acetyl CoA, NADH and FADH2. Based on your biochemical knowledge, the major metabolic intermediate will enter cellular respiration in [Select] , and the reduced coenzymes will enter cellular respiration in [Select] Could a mature red blood cell perform the B-oxidation pathway? Yes, in their cytoplasm.
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- Complete oxidation of a 16-carbon fatty acid can yield 129 molecules of ATP Study Figure 19.2 and determine how many ATP molecules would be generated if a 16-carbon fatly acid were metabolized solely by the TCA cycle, in the form of S acetyl-CoA molecules.Using the ActiveModel for enoyl-CoA dehydratase, give an example of a case in which conserved residues in slightly different positions can change the catalytic rate of reaction.A number of genetic deficiencies in acyl CoA dehydrogenases have been described. This deficiency presents early in life after a period of fasting. Symptoms include vomiting, lethargy, and sometimes coma. Not only are blood levels of glucose low ( hypoglycemia), but starvation-induced ketosis is absent. Provide a biochemical explanation for these last two observations.
- Activation of the fatty acid (converting it to fatty acyl-SCoA) requires the expenditure of 2 ATPs. Use your answers from parts B and C to calculate the total number of ATPs generated from the metabolism of a saturated fatty acid with 18 carbon atoms including both the citric acid cycle and the ββbeta-oxidation pathway as well as the initial ATP required to produce the acyl-SCoA molecule that starts the process. Express your answer as an integer.Most fatty acids have an even number of carbons and, therefore, are completely metabolized to acetyl-CoA. A fatty acid with an odd number of carbonsis metabolized to acetyl-CoA and one equivalent of propionyl-CoA. The following two reactions convert propionyl-CoA into succinyl-CoA, a citric acidcycle intermediate, so it can be further metabolized. Each of the reactions requires a coenzyme. Identify the coenzyme for each step. From what vitaminsare the coenzymes derived? (Hint: see Chapter 23.) COO− COO−CH2CH2methylmalonyl-CoA succinyl-CoA CH3CH2 SCoAFatty acid biosynthesis begins with the condensation of a two-carbon acetyl residue from acetyl-COA and oxaloacetate, while oxidation leads to the release of two carbon units, acetyl-CoA and fatty acyl-CoA. However, these two processes are not simple reversal. Compare and contrast these two pathways.
- The products of pyrimidine base catabolism, β-alanine and β-aminoisobutyrate, can be further degraded to acetyl-CoA and succinyl-CoA, respectively. Can you suggest the types of reaction required to accomplish these transformations?Before β-oxidation, fatty acids must be converted to their CoASH derivatives. Explain why this reaction is necessary.Fatty acids are activated for breakdown through the action of acyl-CoA synthestase. Which of the following statements regarding acyl-CoA synthetase is not true? ● It catalyzes the addition of CoA to the fatty acid One of the products of the reaction is ADP. O The free energy change for the reaction catalyzed by this reaction is close to 0 kJ/mol, but the subsequent hydrolysis of pyrophosphate drives the reaction forward. O The reaction results in the formation of a thioester bond.
- What is unique about how acetyl-CoA carboxylase 1 is regulated compared to any enzyme in glycolysis? Some phospholipid species can be phosphorylated beyond the phosphate attached to the #3 carbon. Describe the likely structure of such a phospholipid. Would the mass / charge (m/z) ratio of this molecular increase or decrease upon modification? Mechanistically, how does NADPH facilitate the removal of an oxygen atom from intermediates in fatty acid synthesis? Will a phosphatidylcholine or a phosphatidylethanolamine have a larger mass / charge (m/z) ratio?Fatty acid oxidation for energy yield occurs in the mitochondrial matrix, and for palmitate as one example, generates [FADN2, NADH, and Acetyle-CoA or FADH, GTP, and NADPH] , all of which can be converted to ATP (108 of them to be exact) via oxidative phosphorylation. This is a [greater or smaller] yield of ATP per carbon atom compared to glucose. Ketogenesis is a process where acetyl-CoA (including that from breakdown of fatty acids) is converted to ketone bodies under conditions where carbohydrates are [in excess or liminting] . Acetoacetate and D-beta-hydroxybutyrate are delivered from liver to the blood stream where they provide energy for [cardiac and skeletal muscle as well as brain or synthesis of glycogen] . [Insulin or glucagon] promotes ketogenesis by stimulating fatty acid export from adipose tissue.The large amount of energy used during aerobic exercise(e.g., running) requires large amounts of oxaloacetate.Explain why acetyl-CoA cannot be used to produceoxaloacetate in this circumstance. What is the sourceof oxaloacetate molecules during aerobic activity?