The reaction ofa ketone with an aldehyde in the preserice of a strong base is an example of a mixed aldol condensation (Claisen-Schmidt reaction). In this example, acetone reacts with two equivalents of benzaldehyde to give dibenzalacetone. As with other condensation reactions, H2O is a by-product of the reaction. N2OH H. + CH-C-CH3 CH=CH-C-CH=CH- 2 H20 2.

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The same physical property that helps drive the reaction to completion can also stall out the reaction before it starts.  What do we do in the procedure that helps minimize this concern?

 

The reaction ofa ketone with an aldehyde in the preserice of a strong base is an example of a mixed
aldol condensation (Claisen-Schmidt reaction). In this example, acetone reacts with two
equivalents of benzaldehyde to give dibenzalacetone. As with other condensation reactions, H2O
is a by-product of the reaction.
NaOH
H.
+ CH-C-CH3
CH=CH-C-CH=CH-
- 2 H20
2.
Transcribed Image Text:The reaction ofa ketone with an aldehyde in the preserice of a strong base is an example of a mixed aldol condensation (Claisen-Schmidt reaction). In this example, acetone reacts with two equivalents of benzaldehyde to give dibenzalacetone. As with other condensation reactions, H2O is a by-product of the reaction. NaOH H. + CH-C-CH3 CH=CH-C-CH=CH- - 2 H20 2.
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