Examine the following peptide and the inserted table, and answer the 2 questions below: Thr-Glu-Pro-Ile-Val-Ala-Pro-Met-Glu-Tyr-Gly-Lys 1. Estimate the net charge of the peptide at pH 2.0. Explain. 2. Estimate the net charge of the peptide at pH 7.0. Explain.
Examine the following peptide and the inserted table, and answer the 2 questions below: Thr-Glu-Pro-Ile-Val-Ala-Pro-Met-Glu-Tyr-Gly-Lys 1. Estimate the net charge of the peptide at pH 2.0. Explain. 2. Estimate the net charge of the peptide at pH 7.0. Explain.
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter26: Synthesis And Degradation Of Nucleotides
Section: Chapter Questions
Problem 22P
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Examine the following peptide and the inserted table, and answer the 2 questions below:
Thr-Glu-Pro-Ile-Val-Ala-Pro-Met-Glu-Tyr-Gly-Lys
1. Estimate the net charge of the peptide at pH 2.0. Explain.
2. Estimate the net charge of the peptide at pH 7.0. Explain.
![Group
Acid
Base
Typical pk.
Terminal a-carboxyl
3.1
group
Aspartic acid
Glutamic acid
4.1
Histidine
6.0
+ H
-N
-N
Terminal a-amino group
8.0
H
H.
Cysteine
H'
8.3
+ H
-N
Lysine
-N
TH
10.8
H.
Тугosine
10.9
H
H
N-H
H
N
Arginine
12.5
N-H
H
N-H
H'
O-U](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F55d60419-60c7-4a41-a370-62f6962a2c52%2F82e46248-4502-4ce3-8678-6d94bf69fcca%2Fm7gouw_processed.png&w=3840&q=75)
Transcribed Image Text:Group
Acid
Base
Typical pk.
Terminal a-carboxyl
3.1
group
Aspartic acid
Glutamic acid
4.1
Histidine
6.0
+ H
-N
-N
Terminal a-amino group
8.0
H
H.
Cysteine
H'
8.3
+ H
-N
Lysine
-N
TH
10.8
H.
Тугosine
10.9
H
H
N-H
H
N
Arginine
12.5
N-H
H
N-H
H'
O-U
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