Answered: Consider an amino acid with the…

Consider an amino acid with the following pKa values: pKa1 = 2.71 and pK, = 9.31 At what pH value in aqueous solution would this amino acid (its predominant form) exist as an anion?

World of Chemistry

7th Edition

ISBN:9780618562763

Author:Steven S. Zumdahl

Publisher:Steven S. Zumdahl

Chapter21: Biochemistry

Section: Chapter Questions

Problem 6A

See similar textbooks

Related questions

Q: A typical amino acid with one amino group and one carboxylicacid group, such as serine, can exist in…

A: At lower pH that means in acidic conditions the carboxylate ion takes up proton and exists as…

Q: A typical amino acid with one amino group and one carboxylic acid group, such as serine can exist in…

A: At lower pH that means in acidic conditions the carboxylate ion takes up proton and exists as…

Q: 2. 1 M valine is present in 1 liter of water at (a) pH 7.5, (b) pH 2.5. For each functional group,…

A: Valine is a nonpolar amino acid with the uncharged structure shown below:

Q: A peptide has the sequence…

A: Solution - According to the question - Given - If pH > pKa, ionizing groups lose their protons.…

Q: Hemoglobin A has a pI value of 5.6 whereas the variant hemoglobin M has an aspartate residue in…

Q: At what pH will the amino group of cysteine be 50% deprotonated? The pKa values are 2.2, 8 and 9.6?…

Q: Consider an amino acid (A) with no ionizable side chains, and call the three species involved in the…

A: Using Hendesen-Hasselbalck equation pH = pKa + log([HA]/[H2A+]) with, [HA] + [H2A+] = 1 mM [HA] = 1…

Q: Show the shift of the electron density and the appearance of partial charges on carbon atoms in the…

A: Given : To determine the electron density and the appearance of partial charges on carbon atoms in…

Q: The amino acid His is triprotic with pK1 (α-COOH) = 1.82, pK2 (α-NH3+) = 9.17, and pK3 (side chain)…

A: If the pKa of acid is equal or lower than the pH of the solution then the acid will get deprotonated…

Q: The amino acid histidine has ionizable groups with pKa values of 1.8, 6.0, and 9.2, COOH H₂N-CH CH…

A: GIVEN The pKa1, pKa2 and pKa3 values of Histidine are given as 1.8, 6.0 and 9.2. Initial pH of…

Q: Explain why the pI of lysine is the average of the pKa values of its two protonated amino groups.

A: First the lysine structure is noted as follows,

Q: Calculate the pH of a 0.0101 M solution of arginine hydrochloride (arginine · HCI, H, Arg*).…

A: Concentration of solution = 0.0101M

Q: Calculate the number of millimoles(mmol)in 500 mg of each of the following amino acids: alanine…

A: The relation between mass, molar mass and mole is given by : Mole = mass/molar mass

Q: Calculate the concentrations of all ionic species in a 0.25 M solution of histidine at pH 2. (Given…

Q: Where is the effective buffering range for this amino acid in the acidic region?

A: Buffer is the solution that resists change in pH when small amount of acid or base is added to it.…

Q: . What is the molecular basis for the observation that the overall charge on a protein becomes…

A: Proteins are the large polymeric compounds made up of monomeric units, namely amino acids. There are…

Q: Draw the tripeptide Alanine-Cysteine-Serine (R1 = CH3, R2 = CH2SH, R3 = CH2OH) under the following…

A: The structure of tripeptide Alanine-Cysteine -Serine is shown in the below steps at different pH, At…

Q: Write the short note on the isoelectric ph of protein and its example??

A: Proteins are large biomolecules which consists of amino acid unit.Protein is an essential food for…

Q: Make

A: According to the question, molecule C4H11N5 was the side chain of an amino acid, in a protein, we…

Q: Illustrate the lONlZATlON STRUCTURES and determine the isoelectric point (pI) of the given amino…

A: We have to illustrate the lONlZATlON STRUCTURES and determine the isoelectric point (pI) of the…

Q: The isoelectric point (pl) of a peptide is the pH at which the Group pK peptide ceases to migrate in…

Q: 5 (a) Describe in detail how you will determine the primary structure of protein. (c) You have been…

A: Amino acids are those hydrocarbons that have a central carbon atom which is attached to a carboxylic…

Q: Consider a buffered solution with a pH of 11 that contains tyrosine as a free amino acid. W the net…

Q: Tyrosine is an amino acid whose side chain has a pKa of 10.1. At pH 7, what protonation form would…

Q: The pKa values of an amino acid are the following: pK1 = 2.18; pK2 = 8.95; pK3 = 10.53, what is…

A: Tha pKa values indicates ; pK1 = 2.18 ( this is the pKa of acidic group) pK2 and pK3 are the pKa…

Q: Calculate the pH of 1.25x10^-2 M of the decongestantephedrine hydrochloride if the pKb of ephedrine…

A: Ka value is calculated.

Q: 2+ The amino acid "arginine (Arg)" has the following form: Arg, HArg, H₂ Arg+, H3 Arg²+. Which is…

A: pH < pka (protonation) pH > pka (deprotonation) pH = 1/2 protonaton or deprotonation

Q: The pK, values for the amino acid leucine (R = CH2CH(CH3)2) are pKa1 = 2.36 and pKa2 = 9.60. Fill in…

Q: Calculate the isoelectric point for below amino acid. methionine: pKa (COOH) = 2.28; pKa (α-NH3+) =…

A: The isoelectric point is defined as the value of pH at which a molecule is neutral i.e. it carries…

Q: Given: Alanine: pKa=4 Pkb=9 Histidine: pKa=2 pKb=6 and pKc=9 Taking the structure of the amino…

Q: The state of ionization of a specific amino acid is directly influenced by the pH of the surrounding…

A: The state of ionization depends upon the pH of the medium. Lysine is a basic amino acid having two…

Q: Plot the titration curves of valine and lysine amino acids in basic medium and calculate the pI…

A: amino acids have ionisable group which ionizes at different condition depending on pH of the…

Q: Calculate the isoelectric point for below amino acid. asparagine: pKa (COOH) = 2.02; pKa (α-NH3+) =…

A: Given: pKa (COOH) = pKa1 = 2.02 pKa (α-NH3+) = pKa2 = 8.80 Isoelectric point (pI) is simply equal to…

Q: Draw the sequential transition of glutamic acid as it passes from its fully protonated form to its…

A: The biomolecules in which carbon atom is bonded to carboxylic group, amine group, alkyl group and…

Q: Determine the buffer capacity of Alanine and Histidine at pH 2.0 and 6.0 respectively and discuss…

A: For the alanine, the value for pKa is 2.34. Now the salt to amino acid ratio to achieve the pH of…

Q: Complete the table for the ionizable groups of the fictitious amino acid hypothetinine. pKa (to TWO…

A: The correct answer is given

Q: Given the chart of pKa’s below, calculate the isoelectric point for tyrosine

A: Isoelectric point (pI):The isoelectric point is the pH of an aqueous solution of an amino acid (or…

Q: A solution of the amino acid Lysine is at pH 13. What will be the overall charge, the charge on the…

Q: Does the titrated amino acids appear to be acidic, basic, or neutral amino acids? Please explain…

A: Amino acid is the acid contains acid group and and the amine group . Ehen there is more than one…

Q: An alpha carboxylic acid group (COOH) of protein amino acids has a pka = 2.4. The ratio of %3D…

A: -COOH, -COO- are acid and its conjugate base. The ratio of -COO-/ COOH can be determined by…

Q: All amino acids have two ionizable functional groups: an a-amino group (average pK, of 9.4) and an…

A: The deprotonation of an acidic group takes place at a pH higher than the pKa value. Hence the…

Q: Which of the common amino acids is not chiral? Sketch its structure and explain why it does not…

A: Glycine is the amino acid which not chiral i.e, Achiral. The structure of Glycine H2N - CH2C ( = O…

Q: A solution of amino acid having carboxylic side chain was titrated against NaOH. If initial pH of…

Q: All amino acids have two ionizable functional groups: an α‑amino group (average pKa of 9.4) and an…

A: The question is based on the concept of amino acids. we have to identify at which pH, this structure…

Q: Consider the amino acid and its pKa values: Lysine: pKa1= 2.18 pKa2= 8.95, pKaR=10.79 a. Calculate…

A: Since you have posted question with multiple sub-parts, we are entitled to answer the first 3.

Q: If an amino acid has pKa1 = 2.71 and pKa2 = 9.31, at what pH value in aqueous solution would the…

Q: Describe three effects of pH on ionization of a weak acid or base that impact biological stability…

A: The three effects of pH on ionization of a weak acid or base that impact biological stability of a…

Q: The isoelectric point (pl) of phenylalanine is pH 5.5. Draw the structure of the major form of…

Q: Almost all proteins are composed from a set of about _____ amino acids. a. 4 b. 10 c. 20 d. 50

A: Hello. Since you have posted multiple questions and not specified which question needs to be solved,…

Question

Consider an amino acid with the following pKa values:
pKa1 = 2.71 and pKa2 = 9.31
At what pH value in aqueous solution would this amino acid (its
predominant form) exist as an anion?

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 2 steps with 1 images

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Metals in Transport, Tranfer and Transcription

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

22-49 Based on your knowledge of the chemical properties of amino acid side chains, suggest a substitution for leucine in the primary structure of a protein that would probably not change the character of the protein very much.
22-45 Proteins are least soluble at their isoelectric points. What would happen to a protein precipitated at its isoelectric point if a few drops of dilute HCl were added?
22-44 How can a protein act as a buffer?
For the amino acid alanine, the major species in solution at pH 7 is the zwitterionic form, which has a negatively charged carboxylic acid group and a positively charged amino group. There is a less common neutral form in which neither group is charged. The carboxylic acid group of alanine has a p?a of 3 The amino group of alanine has a p?a of 8 Estimate the ratio of the concentration of the neutral amino acid species to the zwitterionic species at pH 7. __?__x10^?
All amino acids have two ionizable functional groups: an α‑amino group (average p?a of 9.4) and an α‑carboxylic acid group (average p?a of 2.2). Aspartic acid has an ionizable side chain (R group) with a p?a of about 3.8. One of the possible ionization states of aspartic acid is shown in the image. The protonated form of the R group of aspartic acid is shown in the structure. The ratio of the protonated form to the charged (deprotonated) form depends on the p?a of the R group and the pH of the solution. Select all the pH values at which the charged form of the R group would predominate.
Alanine is a diprotic amino acid with a pKa = 2.344 for the carboxylic group and a pKa = 9.868 for the ammonium group. Estimate the pH of a solution of 0.340 M alanine. Answer using two significant figures.
4 An aqueous solution of an amino acid with a dissociable side chain is found to have the following side chain ratio at pH 4.0: K=[A- ]/[HA]=0.01. What is the identity of the amino acid?
The pKa values for the α-carboxylic acid and the α-amino acid groups is cysteine are 1.092 and 10.78, respectively. The pKa for the titratable −SH side chain in the amino acid is 8.33. Calculate the pI (Isoelectric point) of cysteine.
Identify the following amino acid in aqueous form (at pH = 7.0): (COO)–CH(NH3)–CH(OH)–CH3A. threonineB. glutamic acidC. histidineD. aspartic acidE. lysine
For the amino acid alanine, the major species in solution at pH 7 is the zwitterionic form, which has a negatively charged carboxylic acid group and a positively charged amino group. There is a less common neutral form in which neither group is charged. The carboxylic acid group of alanine has a p?apKa of 3.3. The amino group of alanine has a p?apKa of 8.8. Estimate the ratio of the concentration of the neutral amino acid species to the zwitterionic species at pH 7.
Calculate the pH of a 0.100 M alanine (HL/intermediate form) solution. pKb1 = 4.29 and pKb2 = 11.67.
Complete the table for the ionizable groups of the fictitious amino acid hypothetinine. pka (to TWO decimals) Average charge of group when pH=pK (to ONE decimal) Group Ka alpha-carboxyl 1.38 x 103 alpha-amino 6.02 x 10-10