6 At what pH will the amino group of cysteine be 50% deprotonated? The pKa values are 2.2, 8 and9.6?O 9.6O 2.25.5

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Answered: At what pH will the amino group of…

Chemistry & Chemical Reactivity

9th Edition

ISBN:9781133949640

Author:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel

Publisher:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel

Chapter24: Biochemistry

Section: Chapter Questions

Problem 4PS

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22-44 How can a protein act as a buffer?
The pKa values for the α-carboxylic acid and the α-amino acid groups is cysteine are 1.092 and 10.78, respectively. The pKa for the titratable −SH side chain in the amino acid is 8.33. Calculate the pI (Isoelectric point) of cysteine.
An alpha-helix transmembrane protein has 35 arnino acid residues embedded in a lipid bilayer membrane. What is the thickness of the biological membrane? O 467 AẢ O525À O 126A
Which amino acid has the greatest amount of negative charge at pH = 6.20?
The side chain of the amino acid cysteine has a pKa of 8.00. At the normal pH that exists in cells (pH 7.3), what is the ratio of charged cysteine to uncharged cysteine?
. Describe the pH range of acceptable buffering behavior for the amino acids alanine, histidine, aspartic acid, and lysine.
The amino acid "arginine (Arg)" has the following form: Arg, HArg, H₂ Arg+, H3 Arg²+. Which is the second most prominent species at pH 6.0? pKa1 = 1.82, pKa2 = 8.99, pKa3 = 12.1
All amino acids have two ionizable functional groups: an a-amino group (average pK, of 9.4) and an a-carboxylic acid group (average pK, of 2.2). Glutamic acid has an ionizable side chain (R group) with a pK, of about 4.1. One of the possible ionization states of glutamic acid is shown in the image. H₂N-CH-C-OH CH₂ At what pH would this structure of glutamic acid be the predominant ionization state? Consider the ionization state of all three of the functional groups. OH The protonated form of the R group of glutamic acid is shown in the structure. The ratio of the protonated form to the charged (deprotonated) form depends on the pK, of the R group and the pH of the solution. 2.6 4.1 1.5 Select the pH values at which the charged form of the R group would predominate. 7.0 11.3
Given that C6H11COOH has a pKa = 4.8 and C6H11N + H3 has a pKa = 10.7, what pH would you make the water layer to cause both compounds to dissolve in it?
4 An aqueous solution of an amino acid with a dissociable side chain is found to have the following side chain ratio at pH 4.0: K=[A- ]/[HA]=0.01. What is the identity of the amino acid?
The activity of an enzyme requires a glutamic acid to display its -COOH functional group in the protonated state. Suppose the pK, of the -COOH group is 4.07. (a) Will the enzyme be more active at pH 3.5 or 4.5? Explain. (b) What fraction of the enzymes will be active at pH = 4.07? Explain. (c) At what pH will the enzyme show 78% of maximal activity?
Which amino acid has a greater negative charge at pH = 6.20, glycine or methionine?

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At what pH will the amino group of cysteine be 50% deprotonated? The pKa values are 2.2, 8 and 9.6? O 9.6 O 2.2 O 5.5