BIOS256 Week 4 Lab
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BIOS256 OL, Week 4 Lab
Name:
OL Lab 4: Renal Physiology: Find the mode of action of a diuretic drug
Learning Objectives:
Understand the morphological relationships between the kidney tubules and the circulatory system
Analyze experimental data for calculating glomerular filtration rate
Set up and perform a perfusion of renal tubules, including the calculation of liquid absorption rates
Learn about the epithelial transport mechanism in the kidney tubules
Use experimental data to assess the mode of action of a diuretic drug
Kidneys play a critical role in the filtration and reabsorption of essential substances that are required for the body. In this simulation, you will explore the anatomy of the kidney through 3D holograms and identify the physiological roles in maintaining homeostasis as well as the factors that influence urine regulation.
In this simulation, you will use the kidney from a dissected rat to study the mode of action of
a new diuretic drug and learn the reabsorption process in the renal tubules. You will learn how to calculate the glomerular filtration rate or GFR and learn the hormones that influence urine output. At the end of the simulation, you should be able to correlate the relationship between renal and circulatory systems in controlling blood pressure.
Part 1: Complete Labster- Renal Physiology: Find the mode of action of a diuretic drug
Part 2: Report and Reflection
Purpose: Describe in your own words and in complete sentences, the purpose of this experiment.
The purpose of this experiment is to understand relationships between the kidney
tubules and analyze glomerular filtration rate. Observations: List 2 observations you have made in this simulation.
The nephron is located in both the cortex and medulla and the glomerulus capillaries push out the largest amounts of solutes.
BIOS256 OL, Week 4 Lab
Name:
Answer all the questions below:
1. In the simulation, why was the ascending limb of the nephron selected to study the effect of the diuretic drug? (2 points)
The ascending limb of the nephron was selected because the first filtration step in the kidneys takes place in the glomerulus. 2. What is renal perfusion and how does it affect blood pressure? (2 points)
Renal perfusion helps maintain the amount of urine output. In the case of hypotension renal output is decreased and vice versa. 3. Compare and contrast the cortical and Juxtamedullary nephrons. (2 points)
Juxtamedullary nephrons have their loops of Henle dive deeper into the medulla. While cortical nephrons have shorter loops of Henle. 4. What are the hormones that regulate urine output? (2 points)
(ADH) Antidiuretic Hormone and Aldosterone hormone 5. What is countercurrent multiplication in a nephron and how does it affect the urine concentration? (2 points)
The process of using energy to make an osmotic gradient. Which allows you to absorb water more and produce more urine. 6. Reflection: Reflect on at least 2 key concepts you have learned from this simulation.
How can you apply it to human health and diseases?
Kidneys filtrate and excrete unnecessary solutes and toxins and are in direct response to urine concentration. The nephrons are utilized in the urine concentration, and it goes from the cortex of the kidneys to the medulla.
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O True
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Iblin
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1170
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per second.
https://philkotse.com/toyota-corona-ior-sale-in-baguio/1991-for-sale-in-aid7017151
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Name
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Identify the portion of a foot (12") as indicated by the reading from the zero mark (0) on the scales below. Place your answers
in the spaces provided.
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raur. p
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C of boiling water, and you recorder the following 10 measurements of each sensor. Which Sensor has
higher accuracy, and which one has higher precision.
Sensor
Sensor readings when measuring 100 C
99.65
100.05
103
102
99.3
s1
100.1
99.1
100.5
99
98.8
98.78
96.9
101.4
98.88
99
S2
99.12
98.9
99
98.69
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Q4) Structural Analysis
This bridge is made of two-force members
attached at the ends.
All angles are 45° or 90°. Vertical and
horizontal members are all 0.1m long.
Support A is a pin joint and support B is a
roller.
a) Label each member as Tension (T),
compression (C), or zero-force (Z).
|
+
A
Automatic Zoom
Write T, C, or Z in the boxes. You do not need to show your work.
b) Find the support forces at A and B. Write your answers as vectors.
F₁
F
Ę₂
F3
c) Use the Method of Sections to find the three unknown forces F₁, F2 and F3.
Show all your work and follow the recipe taught in class.
Draw a diagram of the section you are studying.
Clearly indicate which equilibrium equations you are using.
150N
Lx
X
Z
(out of page)
"B
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- 3. Microfluidic channels will need to be fabricated on a key micro-scale sensor used by aerospace industries. Before running machining tests and analyzing machined quality, preliminary efforts are needed to evaluate selected materials and factors affecting machining process¹. Three material candidates have been selected, including 422SS (stainless steel), IN718 (nickel alloy), and Ti64 (titanium alloy) with their measured tensile properties and equation of true stress-true strain relationship used listed below. Tref25°C. Specifically, three factors will need to be evaluated, including different materials, temperature, and size effect. Please calculate true stress values for true strain ranging between 0-3 for each case listed below. Material A (MPa) & (S-¹) Tm (°C) 870 0.01 1520 422SS (Peyre et al., 2007) IN718 (Kobayashi et al., 2008) Ti64 (Umbrello, 2008) 980 1 1300 782.7 1E-5 1660 Material 422SS (CINDAS, 2011) IN718 (Davis, 1997) Ti64 (Fukuhara and Sanpei, 1993) 0 = X G (GPa) 1+ B…arrow_forward2. The results from a settling column test performed on a municipal sewage from a certain town were as presented below. The experiments were conducted on a sample of sewage which is sieved through a 1.2 mm mesh to remove gross solids that would block valves. 501 of the sample weighed 1.352 gm. After drying. Sampling Time (min.) 0 60 180 360 Experimental results for amount of SS remaining in the sample (mg/l) Sampling depth (cm) 100 230 150 118 90 200 230 150 143 115 300 230 159 147 134 400 230 157 152 145 The sewage treatment work incorporates two primary settlement tanks each of a diameter of 25 m. The sewage flow to the tanks is 0.3 m³/s. Find the percentage expected SS removal at the works.arrow_forwardQUESTION 2 Thermocouples are devices used to measure temperature of a given sample or the surrounding medium. These devices feature a "bead", which has a spherical shape, and produces voltage upon change in temperature. For an engineering application at a pharmaceutical company, thermocouple devices are being tested for their responsiveness, i.e. how fast it can detect temperature changes in the environment (surrounding air). The engineers at this company have specified design constraints for an ideal thermocouple: it must detect temperature changes no later than 1.5 minute, and the reported temperature value must be reasonably correct: at most %3 difference between measured and actual temperature values is allowed. Four thermocouples from different vendors are being tested. Relevant properties of these devices are listed below: Thermal conductivity Density 36 W/m*K 36 W/m*K 42 W/m*K 33 W/m*K Specific Heat 140 kJ/kg*K 120 kJ/kg*K 150 kJ/kg*K 160 kJ/kg*K Device Bead Diameter…arrow_forward
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