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What is the importance ofKRAS gene in the development of colorectal cancer. ?
Step by step
Solved in 3 steps
- What is the sequential pattern of mutations commonly observed in the development of colorectal adenocarcinoma, and how do these genetic alterations contribute to tumorigenesis and disease progression? Discuss key genes and signaling pathways involved, including APC, KRAS, and TP53 and describe how these mutations disrupt normal cellular functions and promote uncontrolled growth in colorectal cancer.explain and analyse each gene mutaition in the CIN, MSI, CIMP pathways and what are the causes of these mutations in regards to adenocarcinoma tumours colorectal cancer. Provide detailed analysis with examplesThe development of colon cancer is particularly well- studied, and often has a predictable order of mutations. Briefly describe the most common steps in the progression of colon cancer in the order of key genes mutated.
- How colorectal cancers develop through the accumulation of mutations in several genes ?1. the wnt story:- a) Discuss the role of Wnt pathway in the normal development of epithelia within the colon – stem cells, differentiated epithelia, and shedding epithelia. b)Then discuss how this path gets altered in the familial cancer FAP – familial adenomatous polyposis? How does it get impacted in non-hereditary colon cancer? Your discussion should explain how the altered wnt path leads to hyperplastic epitheliaExplain the multi hit approach to colorectal cancer regarding the pathways CIN chromosomal instability (CIN), microsatellite instability (MSI). explain step by step. what genes are involved.
- According to the American Cancer Society, colon cancer screening should begin at age 50 for people at average risk. Imagine you have a family history of colon cancer. From your research, with reasons which procedures would your physician order for you and at what age ?What is a good conclusion for causes of colon cancer ?What significance do BRCA1 and BRCA2 have in regard to developing cancer, and what types of cancer are associated with these genes?
- What are the underlying biological mechanisms that differentiate the various types of cancer, and how can a better understanding of these mechanisms lead to more targeted and effective treatments for each specific type of cancer?How the genes, when mutated, contribute to the development ofcancer ?Hereditary retinoblastoma generally affects children in both eyes, while spontaneous retinoblastoma usually occurs during adulthood only in one eye. Explain the genetic basis for the epidemiological distinction between these two forms of retinoblastoma. Explain the apparent paradox: loss-of-function mutations in tumor-suppressor genes act recessively, yet hereditary retinoblastoma is inherited as an autosomal dominant.
