Question 11Two different capsule formulations of cilostazol, which is poorly water soluble, were prepared. In a group of volunteers, the relativebioavailabilies of the two formulations were calculated relative to an oral suspension of the drug given to the same group at the samedose.Formula A (mechanically ground drug powder) Frel = 0.9Formula B (stabilised amorphous powder) F rel= 2.1Frel=FAXFGXFHAfter consideration of the equation shown above, what is the likely reason for the increased F relof formula B compared to formula A?a. FA is increased.b. FG is increased.c. FH is increased.d. None of these are likely.

Let us first mention what bioavailability is. The bioavailability of an administered drug is defined…

Two different capsule formulations of cilostazol, which is poorly water soluble, were prepared. In a group of volunteers, the relative bioavailabilies of the two formulations were calculated relative to an oral suspension of the drug given to the same group at the same dose. = 0.9 Formula A (mechanically ground drug powder) F rel= Formula B (stabilised amorphous powder) Frel=2.1 Frel FAXFGXFH After consideration of the equation shown above, what is the likely reason for the increased F rel of formula B compared to formula A? O a. FA is increased. b. FG is increased. Oc. FH is increased. d. None of these are likely.

Two different capsule formulations of cilostazol, which is poorly water soluble, were prepared. In a group of volunteers, the relative bioavailabilies of the two formulations were calculated relative to an oral suspension of the drug given to the same group at the same dose. = 0.9 Formula A (mechanically ground drug powder) F rel= Formula B (stabilised amorphous powder) Frel=2.1 Frel FAXFGXFH After consideration of the equation shown above, what is the likely reason for the increased F rel of formula B compared to formula A? O a. FA is increased. b. FG is increased. Oc. FH is increased. d. None of these are likely.

Chemistry: Principles and Reactions

8th Edition

ISBN:9781305079373

Author:William L. Masterton, Cecile N. Hurley

Publisher:William L. Masterton, Cecile N. Hurley

Chapter10: Solutions

Section: Chapter Questions

Problem 86QAP: A martini, weighing about 5.0 oz (142 g), contains 30.0% by mass of alcohol. About 15% of the...

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