Question 9Briefly discuss the discovery and development of selective inhibitors of sodium-glucoselinked transporter 2 (SGLT2) based on the natural product phlorizin (structure below).Illustrate your answer with suitable chemical structures and diagrams.HolanOHHOНО.OHOHOH

Sodium-glucose linked transporters (SGLTs) , or to be more specific Sodium-glucose linked…

Answered: Question 9 Briefly discuss the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question 3 Match the following descriptions to the given choices. The first molecule in the biosynthesis of steroids A. Aldosterone that contains the cyclopentanoperhydrophenanthrene ring B. Androstenedione C. Estrone The sterol that will serve as the precursor for the synthesis of bile acids and steroid hormones D. Cholic acid v A bile acid E. Cholesterol v A mineralcorticoid F. Lanosterol Promotes male secondary sex characterictics
QUESTION 28 Recall the reaction catalyzed by phosphoglucomutase: glucose-1-phosphate glucose-6-phosphate Assume that in liver cells under fed conditions, the G1P concentration = 2.5x10-2 M, and the G6P concentration = 1x10-3 M. Using the equation AG = AGO + RTIN([product)/freactant]), calculate AG for the reaction, given that: AGO = -7.1 kJ mol-1 R = 8.315x10-3 kJ mol-1 K-1 T = 310 K (37°C) In which direction will the reaction proceed spontaneously under these conditions? O +1.2 kl mol1; reverse reaction spontaneous. O -3.5 kl mol-1: forward reaction spontaneous. O -10.7 k) mol1; forward reaction spontaneous. O -15.4 kJ mol1; forward reaction spontaneous.
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QUESTION 1 Which of the following concepts in column A best fits the concept in column B. p-Nitrophenyl a-D-Glucoside Action of intracellular a-GLUCOSIDASE + NaHCO3 Boiling cells Tris-pH 5.0 A. Substance that act as molecular mimic of a maltose molecule B. Develops TT-Nitrophenyl into a yellow colour reagent for measurement at 400nm c. Breaks the a-linkages of p-Nitrophenyl a-D-Glucoside, leaving p-Nitrophenyl and a glucose molecule D. Allows transport of p-Nitrophenyl a-D-Glucoside across the membrane E. Stop the reaction and release internal p-Nitrophenyl
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Question 9 Briefly discuss the discovery and development of selective inhibitors of sodium-glucose linked transporter 2 (SGLT2) based on the natural product phlorizin (structure below). Illustrate your answer with suitable chemical structures and diagrams. HO НО. OH OH OH OH