Question 2. An enzyme was found to convert Acetyl-coA to an acetyl-cysteine intermediate of the enzyme. The structure of COA is: H H НО СН, HS — СH2— СH, — N—С— СН, — СН;—N—С Ċ–Ċ–CH2-0 0-P-0-CH2 Adenine H CH5 H H H H Phosphopantetheine group of coenzyme A 2-O,PO OH Draw a plausible chemical mechanism. Where is the acetyl-group in acetyl-coA? What is the reactive group of the protein? The reaction is enhanced at higher pH. How is this consistent with your mechanism? Is covalent catalysis involved? www
Question 2. An enzyme was found to convert Acetyl-coA to an acetyl-cysteine intermediate of the enzyme. The structure of COA is: H H НО СН, HS — СH2— СH, — N—С— СН, — СН;—N—С Ċ–Ċ–CH2-0 0-P-0-CH2 Adenine H CH5 H H H H Phosphopantetheine group of coenzyme A 2-O,PO OH Draw a plausible chemical mechanism. Where is the acetyl-group in acetyl-coA? What is the reactive group of the protein? The reaction is enhanced at higher pH. How is this consistent with your mechanism? Is covalent catalysis involved? www
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter18: Glycolysis
Section: Chapter Questions
Problem 24P: Based on your knowledge of the structure of NAD+ and an assumption that coenzyme dissociation is the...
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