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In the RBCs of the patient in the picture, which of the following would be expected? Explain.
A. ADP to ATP ratios would be elevated above normal
B. NADP+ would increase relative to NADPH
C. Ribulose 5-phosphate levels would increase
D. NADH to NAD+ ratios would decrease
E. Methemoglobin levels would increase
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- A fever is considered to be a ____________________________. prognosis sign symptom syndromea 58-year-old Asian male .He visited his physician because he noticed dark colored lesions on his inner thighs, have increased in number, size. For the last three months he has been feeling weaker and more fatigued than usual; his weight dropped from 170 to 155 pounds. Xin’s blood was drawn and testing was conducted. His hematocrit was 45% and white-blood cell count was 2,500 white-blood cells/mm3, with the differential showing neutrophils 65%, lymphocytes 25%, monocytes 10%. A biopsy was taken of one of the discolored lesions and grown in cell culture. After three days of growth the cells were confirmed as coming from malignant cancerous tissue. A magnetic resonance image (MRI) of the area around the skin lesions on Xin’s inner thigh revealed enlarged lymph nodes, a sign of potential metastasis. What possible Diagnosis or disorders can you rule out for this paitentBACKGROUND A 2-year-old black girl is being seen by the hematologist after her pediatrician found her to be severely anemic with splenomegaly and jaundice. Her mother gives a possible history of a “blood problem” in her family but doesn’t know for sure. Her hemoglobin electrophoresis was normal, and the complete blood count (CBC) revealed a normocytic anemia. The platelet and white blood cell counts are normal. On the peripheral smear, there are many bizarre erythrocytes, including spiculated cells. A diagnosis of pyruvate kinase deficiency is made. Pyruvate kinase deficiency (PKD) can be inherited in an autosomal recessive manner, which means that a child must inherit a gene with the disease-causing mutation from both parents in order for the disorder to be inherited. The PLKR gene regulates the synthesis of the pyruvate kinase enzyme, which is located in the liver and red blood cells. Pyruvate kinase deficiency (PKD) is a rare genetic disorder characterized by the premature…
- A 2-year-old black girl is being seen by the hematologist after her pediatrician found her to be severely anemic with splenomegaly and jaundice. Her mother gives a possible history of a “blood problem” in her family but doesn’t know for sure. Her hemoglobin electrophoresis was normal, and the complete blood count (CBC) revealed a normocytic anemia. The platelet and white blood cell counts are normal. On the peripheral smear, there are many bizarre erythrocytes, including spiculated cells. A diagnosis of pyruvate kinase deficiency is made. In the RBCs of the patient described above, which of the following would be expected? And give the explanation. (3 sentences) ADP to ATP ratios would be elevated above normal. NADP+ would increase relative to NADPH. Ribulose 5-phosphate levels would decrease. NADH to NAD+ ratios would decrease. Methemoglobin levels would increase.In two complete sentences tell me the definition of a reticulocyte and why would we see an increase of them in the circulating blood BIUA - A - I E E 3 X x, = E Paragraph 12pt frA female 40 year old patient has a hematocrit of 60%, an elevated reticulocyte count, and splenomegaly. What is a possible condition this patient has? O chronic myelogenous leukemia O lymphoma O aplastic anemia O pernicious anemia O polycythemia O thrombocytopenia O septicemia
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- Trisha has another baby with Johnny (Charlotte's father). Shortly after the birth of this baby, the newborn was immediately transported to the Neonatal Intensive Care Unit. The doctors informed Trisha that this baby was suffering from hemolytic disease of the newborn. Explain (i) how hemolytic disease of the newborn arose in Trisha’s second child, (ii) how it should have been prevented, and (iii) the mechanism of action of the preventative treatment for this condition. Please LABEL the parts of your answer to this question (i), (ii), and (iii).M.L. is a 26-year-old homosexual man admitted to the hospital for progressive respiratory distress, fever, weakness, and chronic diarrhea. He tested HIV positive about 3 years ago, but his infection has remained asymptomatic until 2 months prior to admission. Pneumocystis jiroveci (carinii) pneumonia was suspected and confirmed by culture. Laboratory analysis demonstrates a low CD4+ count of 185 cells/ml. HAART treatment with the antiretrovirals azidothymidine (AZT), efavirenz (Sustiva), and ritonavir (Norvir) was started 2 months ago. QUESTIONS: P. jiroveci pneumonia is an opportunistic infection to which immunocompetent people are immune. What other opportunistic infections are commonly seen in AIDS patients? Are there any data to suggest that M.L. may have one of these? A medical student asks you to draw a picture of the HIV virion and a CD4+ cell, and to explain the mechanism of intracellular infection and the role of reverse transcriptase. What would you show on the drawing…What are sickle-cell animaia?