Consider the structure of the tripeptide below. H H₂N-C-C- 0=6 CH₂ CH₂ C=0 1 NH₂ pH 5: O pH 10: H O -N-C-C 1 H HN 0=0 CH₂ NH -N- 1-6-5- O CICIOH 1. What is the sequence of the tripeptide? (use the one-letter symbol, do not put dash or space in between symbols) 2. What is the net charge of the dominant structure of the tripeptide at the given pH values? The pK, values of the amino acids are given in Table 1. H CH-OH CH3
Consider the structure of the tripeptide below. H H₂N-C-C- 0=6 CH₂ CH₂ C=0 1 NH₂ pH 5: O pH 10: H O -N-C-C 1 H HN 0=0 CH₂ NH -N- 1-6-5- O CICIOH 1. What is the sequence of the tripeptide? (use the one-letter symbol, do not put dash or space in between symbols) 2. What is the net charge of the dominant structure of the tripeptide at the given pH values? The pK, values of the amino acids are given in Table 1. H CH-OH CH3
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:Amino acid
Gly
Ala
Val
Leu
lle
Pro
Phe
Tyr
Trp
Ser
Thr
Cys
Met
Asn
Gin
Asp
Glu
Lys
Arg
His
Table 1. pk, values of the standard amino acids.
pK₂1
(a-carboxyl)
2.34
2.34
2.32
2.36
2.36
1.99
1.83
2.20
2.38
2.21
2.11
1.96
2.28
2.02
2.17
1.88
2.19
2.18
2.17
1.82
pK₂2
(protonated a-amino)
9.60
9.69
9.62
9.60
9.68
10.96
9.13
9.11
9.39
9.15
9.62
10.28
9.21
8.80
9.13
9.60
9.67
8.95
9.04
9.17
PKR
(side chain)
10.07
8.18
3.65
4.25
10.53
12.48
6.00
Transcribed Image Text:Consider the structure of the tripeptide below.
H O
11
H₂N-C-C-N-C-c-
CH₂
CH₂
C=0
NH₂
pH 5:
Z-I
pH 10:
H
HN
H O
11
CH₂
NH
HIC-
I-Z
0=6
-N-C-C-OH
1. What is the sequence of the tripeptide? (use the one-letter symbol, do not put dash or space in between symbols)
2. What is the net charge of the dominant structure of the tripeptide at the given pH values? The pK, values of the amino acids are given in Table 1.
CH-OH
T
CH3
Table 1. pk, values of the standard amino acids.
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