b. (2 pts each, 4 pts total) Consider the pKa for the following compounds. Put the letter for the appropriate compound (highest or lowest pKa) in the appropriate box. ΟΗ B ΟΗ highest lowest ΌΗ ΟΗ F F E C C
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- Pregabalin, C3H17NO2 is used as a treatment of epilepsy and neuropathic pain. NH2 pK, = 4.2 %3D H. pK = HO, = 3.4 Select the equilibrium corresponding the to the pK, = 9.8 CgH18NO2 (aq) + H20 (I) C3H17NO2 (aq) + OH (aq) C3H16NO2 (aq) + H20 (1) CgH17NO2 (aq) + OH (aq) CgH17NO2 (aq) + H20 (1) C3H18NO2 *(aq) + OH (aq) C3H17NO2 (aq) + H20 (1) CgH16NO2 (aq)+ H30*(aq)Directions: Identify the type of IMFA for the following substances and answer the questions that follow. Table 1 - Substances and IMFA Types Substance Type of IMFA 1. CO 2. NH3 3. CC14 Critical Thinking Questions: 1. How do you determine the type of IMFA that occurs in each of the given substances? 2. Rank the strength of each compound based on IMFA. (1 = strongest, 2 = in between, 3 = weakest) Explain your answer.Which species is the conjugate acid of ammonia, NH3? Select one: O a. HẠN O b. H3N* О с. НN O d. HẠN* Which compound has the lowest pk,? Select one: O a. H2O O b. H2S NH3 O d. CH4 Which compound is the strongest acid? CH4 CH,CH3 H2C=CH2 HCECH II IV Select one: O a. Ob. О с. II O d. IV
- Which of the compounds have the lowest pKA, why?Rank compounds L-P in order of decreasing acid strength, from lowest pk, to highest pka. Explain. L M3), largest pka value? Which of the following carboxylic acid containing molecules has the ÇI COH CI ÇI CI CO2H COH .CO2H .CO2H CI CI CI (d) CI CI (a) (b) (c) (e)
- The weakest of the acids below is and its pK is The strongest of the acids below is and its pK is 4.21 4.76 imidazolium ion 5.64 8.20 succinate boric acid formic acid 4.21 4.76 imidazolium ion 5.64 8.20 succinate boric acid formic acid phosphoric acid succinic acid 3.75 7.00 p-nitrophenol 9.24 acetic acid 0.18 9.25 glycinamide ammonium ion 2.15 7.24Part B Benzoic acid is a weak acid that has antimicrobial properties. Its sodium salt, sodium benzoate, is a preservative found in foods, medications, and personal hygiene products. Benzoic acid dissociates in water: C6H5 COOH(aq) + H₂O(1) C6H5COO- (aq) + H3O+ (aq) -1 The pK₂ of this reaction is 4.2. In a 0.66 mol L-¹ solution of benzoic acid, what percentage of the molecules are ionized? Express your answer to two significant figures and include the appropriate units.; Which of the following carboxylic acid containing molecules has the largest pKa value? CI CI CI .CO2H .CO2H .CO2H CI .CO2H .CO2H CI CI CI CI (d) (a) (b) (c) (e)