A researcher found that a single point mutation in the genome of the SARS-CoV-2 virus resulted in change in the spike protein with a His residue being replaced by an Asn. This mutation resulted in significantly increased ability for the virus to evade the immune system. Which of the following is the most likely explanation for this? O changing from His to Asn is a very significant change since Asn is not able to form hydrogen bonds that might have been critical for spike protein-antibody interaction O since Asn is commonly glycosylated, the new residue is likely a new glycosylation site which prevents antibody interaction O the His residue was most likely protonated and positively charged while Asn is neutral and the interaction between the spike protein and antibody is likely through a single electrostatic interaction the His residue was likely recognized by TMPRSS2 and its removal prevented destruction by the protease

A researcher found that a single point mutation in the genome of the SARS-CoV-2 virus resulted in change in the spike protein with a His residue being replaced by an Asn. This mutation resulted in significantly increased ability for the virus to evade the immune system. Which of the following is the most likely explanation for this? O changing from His to Asn is a very significant change since Asn is not able to form hydrogen bonds that might have been critical for spike protein-antibody interaction O since Asn is commonly glycosylated, the new residue is likely a new glycosylation site which prevents antibody interaction O the His residue was most likely protonated and positively charged while Asn is neutral and the interaction between the spike protein and antibody is likely through a single electrostatic interaction the His residue was likely recognized by TMPRSS2 and its removal prevented destruction by the protease

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter23: Enzymes

Section: Chapter Questions

Problem 23.25P: 5 Which of the following is a correct statement describing the induced-fit model of enzyme action?...

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5 Which of the following is a correct statement describing the induced-fit model of enzyme action? Substrates fit into the active site: (a) because both are exactly the same size and shape. (b) by changing their size and shape to match those of the active site. (c) by changing the size and shape of the active site upon binding.
Suppose that peptide N and O are segments in the globular protein's primary structure, where will each peptide (a. Peptide N and b. Peptide O) be most likely located - is it on the surface, completely exposed to the aqueous environment, or interior of the protein? Explain. Peptide N: L--L--F--A--I--A--M--F--L--N--I--A--I--A--I Peptide O: S--T--E--K--D--R
A mutational change alters a polypeptide by substitutingthree adjacent prolines for three glycines. What possibleeffect will this event have on the protein’s structure?
Cyanogen bromide fragments: SDKARPM, DSKLAM, DEM, DQ Trypsin fragments: LAMSDK, ARPMDQ, DEMDSK What is the sequence of the original peptide? ARPMDQDEMDSKLAMSDK ODEMDSKLAMSDKARPMDQ OLAMSDKDEMDSKARPMDQ DEMDSKARPMDQLAMSDK
Why is peptide synthesis carried out from C terminus to N terminus using dicyclohexylcarbodiimide (DCC)? Can you illustrate the explanation with a mechanism/drawing?
Decide if the side chains of the following peptides are nonpolar or polar, and label the hydrophobic and hydrophilic end of each peptide.a. VLLFGEDEKb. RKYSFLGAA
Anser the following questions for the peptides below
Proteins are often constructed from multiple segments of 40-200 amino acid residues, commonly called domains and the site where the chemistry of catalysis occurs within a possible domain is called OA binding site OB. protolytic fragment OC pseudosto OD allostenic ste OE active se
In a gene mapping experiment, DNA from a prototrophic E. coli strain is transformed into an E. coli strain mutant (auxotrophic) for the genes gal, pro, and lac. Some resulting transformants were found to be auxotrophic only for pro, and some only for gal, but no laconly auxotrophs were observed. Based upon these results, which gene is in the middle? a. gal b. lac c. pro d. cannot be determined e. the genes are not on the same chromosome
OF OFFIC NSCR ly cloudy Which of the following statements is NOT true about the peptide named glycylserylphenylalanine? O Glycine is the N-terminus. O It is a tripeptide. O Alanine is the C-terminus. O Phenylalanine is the C-terminus. 69 % 5 f6 6 & 7 Os hp 8
Part B Rank the following peptides from most to least hydrophobic. Rank the peptides from most to least hydrophobic. To rank items as equivalent, overlap them. • View Available Hint(s) Reset Help Asn-Arg-Ser-Arg-Asn Ser-Arg-Leu-Asn-Val Trp-Arg-Leu-Asn-Pro Trp-Leu-Arg-Pro-Leu Trp-Leu-Pro-Val-Leu Most hydrophobic Most hydrophilic
+ H₂N- Protein CPMV N